Spectrum of Pediatric Brain Tumors: A Report of 341 Cases from a Tertiary Cancer Center in India

Das, Umesh; Appaji, L.; Kumari, Babita; Sirsath, Nagesh T; Padma, M.; Kavitha, S.; Avinash, T.; Lakshmaiah, K C

doi:10.1007/s12098-014-1387-6

Cited by 9 publications

(11 citation statements)

References 5 publications

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“…GBM constituted 12% of their childhood brain tumors (12). We also observed a similar trend; there was a dramatic increase in the incidence of GBM (other than brainstem) after 6 years of age (19% vs. 81%) (Table I).…”

Section: A B C Dsupporting

confidence: 77%

Is the knowledge pertained to adult glioblastomas enough for pediatric cases? prognostic factors in childhood

Bilginer¹,

Hanalıoğlu²,

Türk³

et al. 2015

Turkish Neurosurgery

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There is a paucity of information in the literature about agespecific histopathological and molecular biology. This is also true for prognostic factors and therapeutic strategies regarding pediatric glioblastoma. The current understanding is therefore majorly based on adult data.The incidence and spectrum of pediatric CNS tumors have been addressed in several studies in the literature. Despite geographical differences, the incidence of glioblastoma was updated to 7-12 % of all pediatric brain tumors (12,30). (8,21). This predominance is responsible for the general perception regarding GBM as a "tumor of the elderly". Indeed, pediatric cases are rare, accounting for 3-6 % of all glioblastomas. The incidence may be responsible for the underestimation of this devastating pathology in childhood.AIM: Pediatric glioblastoma (GBM) is still a topic obscurity. The aim of this study was to explore clinical, radiological and pathological features, and prognostic factors affecting the outcomes. MATERIAL and METhODS:We retrospectively reviewed our database for prognostic factors for 42 consecutive pediatric patients with histologically proven GBM treated in our hospital. RESuLTS:The study reached at 20 boys and 22 girls, with a mean age of 10.2 years. Almost all patients (97.6%) had supratentorial tumors; lobar/hemispheric (68.3%), thalamic (26.8%) and suprasellar-hypothalamic region (4.8%). Total of 11/42 children had seeding metastases (mean 11.5 months) either preoperatively or postoperatively. Gross total resection (GTR) was achieved in 13 patients (30.9%) in the first surgery. Perioperative mortality and morbidity rates were 4.7% and 19%, respectively. Patients were followed for an average of 18.1 months. The median progression-free and overall survivals were 7.0 (95% CI: 5.9-8.0) and 11.0 (95% CI: 8.9-13.1) months, respectively. 1-year, 2-year and 5-year progression-free survival and overall survivals were 30.9% vs. 50.0%, 11.9% vs. 19.0%, 4.8% vs. 9.5%; respectively.COnCLuSIOn: Gross total resection should be safely attempted in pediatric GBM. In addition, a thorough and frequent radiological evaluation of the entire neuraxis for seeding metastases is recommended both at diagnosis and follow-ups.

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Section: A B C Dsupporting

confidence: 77%

Is the knowledge pertained to adult glioblastomas enough for pediatric cases? prognostic factors in childhood

Bilginer¹,

Hanalıoğlu²,

Türk³

et al. 2015

Turkish Neurosurgery

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“…ODGs can be found in the cerebral hemispheres of the brain, but they primarily arise in the frontal and temporal regions, can be low or high grade (anaplastic ODG), or mixed (ODGastrocytomas) (Engelhard et al 2002;Wagner et al 2015), and primarily affect adults. They account for~1-4% of primary pediatric brain tumors and 3-10% of all pediatric gliomas (Das et al 2014;Kaderali et al 2009;Rosemberg and Fujiwara 2005). ODGs do not frequently arise due to germline mutations; however, pediatric case reports of ODGs have been reported among those with CMMRD (De Rosa et al 2000;Menko et al 2004;Poley et al 2007) and at least one teen with Lynch syndrome (Heath et al 2013).…”

Section: Oligodendroglioma (Odg)mentioning

confidence: 99%

A Comprehensive Review of Pediatric Tumors and Associated Cancer Predisposition Syndromes

Scollon

Anglin

Thomas

et al. 2017

Journal of Genetic Counseling

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An understanding of the role of inherited cancer predisposition syndromes in pediatric tumor diagnoses continues to develop as more information is learned through the application of genomic technology. Identifying patients and their relatives at an increased risk for developing cancer is an important step in the care of this patient population. The purpose of this review is to highlight various tumor types that arise in the pediatric population and the cancer predisposition syndromes associated with those tumors. The review serves as a guide for recognizing genes and conditions to consider when a pediatric cancer referral presents to the genetics clinic.

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“…[ 1 2 3 ] There are not many studies from India which have looked into the epidemiology of pediatric brain tumors and compared it with data from the rest of the world. [ 4 5 6 7 8 9 10 11 12 ] Since this is a hospital-based study, it may not reflect the true epidemiology of the tumors, but nevertheless, it is the first attempt of its kind from Kerala. The aim of this study was to analyze the epidemiology of pediatric brain tumors in North Kerala and compare it with data from the rest of India and other countries.…”

Section: Introductionmentioning

confidence: 99%

Pediatric intracranial tumors over a 5-year period in a tertiary care center of North Kerala, India: A retrospective analysis

Govindan¹,

Parambil²,

Alapatt³

2018

Asian J Neurosurg

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Background:Pediatric brain tumors are unique in terms of distribution, clinical presentation, pathologic types, management, and prognosis. There are not many studies from India which have looked into the epidemiology of pediatric brain tumors.Aims:This study aimed to analyze the epidemiology of pediatric brain tumors in North Kerala and compare it with data from the rest of India and other countries.Materials and Methods:This is a retrospective study of 5-year data of pediatric brain tumors which were operated in a tertiary referral center in North Kerala, India, from 2009 to 2013. The data were procured from the departments of neurosurgery and pathology of the institution. The data were tabulated and analyzed using SPSS software.Results:A total of 71 children had histologically proven brain tumors during the 5-year period. There were 34 boys and 37 girls. Distribution in different age groups was as follows: infancy –5 (7%), 1–5 years –22 (31%), 6–10 years – 21 (29.6%), and 11–18 years – 23 (32.4%). The most common tumors were primitive neuroectodermal tumors (PNETs). In infancy, the number of high-grade tumors was more, whereas in the 11–18 years’ age group, there were a significantly higher number of low-grade tumors (P = 0.04).Discussion:Pediatric brain tumors were distributed almost equally in both sexes. PNET was the most common. We could not get statistical significance in many of our values due to small sample size.Conclusion:This study highlights the need for diligent collection of data and maintenance of a registry for brain tumors to study the disease in the Indian population.

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Spectrum of Pediatric Brain Tumors: A Report of 341 Cases from a Tertiary Cancer Center in India

Cited by 9 publications

References 5 publications

Is the knowledge pertained to adult glioblastomas enough for pediatric cases? prognostic factors in childhood

Is the knowledge pertained to adult glioblastomas enough for pediatric cases? prognostic factors in childhood

A Comprehensive Review of Pediatric Tumors and Associated Cancer Predisposition Syndromes

Pediatric intracranial tumors over a 5-year period in a tertiary care center of North Kerala, India: A retrospective analysis

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