Outcomes of whole-body computed tomography in spinal cord-injured patients with sepsis

Ahmed, Wail; Heredia, Luís; Hughes, Richard J.; Belci, Maurizio; Meagher, Tom

doi:10.1038/sc.2014.42

Cited by 3 publications

(2 citation statements)

References 7 publications

(4 reference statements)

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“…Examples of such a scenario may include patients with septic shock or fever with altered mental status but no clear source of infection after initial evaluation with a history, physical examination, laboratory work, and chest radiography. 32 , 33 , 34 …”

Section: Discussionmentioning

confidence: 99%

Community-Acquired Pneumonia Visualized on CT Scans but Not Chest Radiographs

Upchurch

Grijalva

Wunderink

et al. 2018

Chest

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Section: Discussionmentioning

confidence: 99%

Community-Acquired Pneumonia Visualized on CT Scans but Not Chest Radiographs

Upchurch

Grijalva

Wunderink

et al. 2018

Chest

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“…In a study of SCI patients ( n = 22) with suspected or known sepsis, investigators found that chest-abdomen-pelvis CT identified a specific radiologic diagnosis in 14 % and non-specific findings in 68 %. Although the bulk of findings were non-specific, a small portion of patients had significant radiologic findings that influenced their management [ 54 ].…”

Section: Discussionmentioning

confidence: 99%

Beyond broken spines–what the radiologist needs to know about late complications of spinal cord injury

2014

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ObjectiveTo describe expected imaging findings to assist the emergency room radiologist with recognising complications and pathology unique to the spinal cord injury (SCI) patient population to ensure rapid and accurate diagnosis.MethodsPictorial review.ResultsWe review several imaging findings common to persons with chronic SCI, emphasising imaging in the emergency setting and on CT.ConclusionSCI patients present a unique diagnostic challenge, as they may present with symptoms that are difficult to localise because of abnormal sensation and autonomic instability. Imaging plays an important role in the emergent setting, rapidly differentiating the most commonly encountered complications from less common, unanticipated complications. Radiologists need to be attuned to both the expected findings and potential complications, which may be unique to SCI patients, to ensure accurate diagnosis and treatment in the emergency setting.Main Messages• Medical complications after spinal cord injury are common and associated with significant morbidity.• Radiologists should be aware of complications unique to the SCI population to aid diagnosis.• Due to abnormal sensation, SCI patients often present with symptoms that are difficult to localise.• In the ED, imaging helps to rapidly differentiate common complications from less anticipated ones.

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ProS/Mer alleviates sepsis-induced neuromuscular dysfunction by inhibiting TLR4/MyD88/NF-κB signals

Xie

Sun

Zhang

et al. 2022

Preprint

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Background Sepsis remains a significant cause of morbidity and mortality worldwide, with systemic inflammation and behavioral impairment. Microglia are well-known critical regulators of neuroinflammation, which feature in multiple neurodegenerative disorders. These cells become “activated” through stimulation of toll-like receptors (TLRs), resulting in changes in morphology and production and release of cytokines. Myeloid-epithelial-reproductive tyrosine kinase (Mer), a member of the Tyro-Axl-Mer (TAM) family of receptor tyrosine kinases, regulates multiple features of microglial/macrophage physiology. The present study examined the roles of the related TAM receptors, Mer, and its ligand, Protein S (ProS), in regulating neuroinflammation and neuromuscular function following sepsis. Methods The sepsis was established by cecal ligation and puncture (CLP) in wildtype (WT) and Mer−/− rats, and recombinant protein S (ProS) or normal saline (NS) was intrathecally injected for intervention. The muscle weight, neuromuscular function, Nissl staining, immunofluorescence, ELISA, and Western blot were performed. Results Knockout of Mer showed significantly decreased muscle weight and neuromuscular function at day 4 post-CLP, as well as increased inflammatory cytokines, activated microglia/macrophage, and TLR4/MyD88/NF-κB signal pathway in the spinal cord. The administration of ProS activated the signal transducer and activator of transcription 1 (STAT1)/suppressor of cytokine signaling 1/3 (SOCS1/3) pathway and inhibited the TLR4/MyD88/NF-κB signal pathway, which alleviated the neuromuscular dysfunction after CLP. Conclusion ProS/Mer alleviates muscle atrophy and neuromuscular dysfunction in the sepsis model by activating the STAT1/SOCS signaling pathway and inhibiting the TLR4/MyD88/NF-κB signaling pathway.

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Outcomes of whole-body computed tomography in spinal cord-injured patients with sepsis

Abstract: Although in the majority of cases, the findings were non-specific, a small number of patients had significant pathology identified by CT, which influenced their management significantly.

Cited by 3 publications

References 7 publications

Community-Acquired Pneumonia Visualized on CT Scans but Not Chest Radiographs

Community-Acquired Pneumonia Visualized on CT Scans but Not Chest Radiographs

Beyond broken spines–what the radiologist needs to know about late complications of spinal cord injury

ProS/Mer alleviates sepsis-induced neuromuscular dysfunction by inhibiting TLR4/MyD88/NF-κB signals

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