Influence of antimicrobial regimen on decreased in-hospital mortality of patients with MRSA bacteremia

Abstract

5We conducted a retrospective observational study on patients with MRSA bacteremia who 6 were hospitalized between 2008 and 2011. We used univariate and multivariate analysis to 7 evaluate the predictors associated with 30-day mortality. The 7-day and 30-day mortality 8 rates were 12.0% and 25.3%, respectively. According to multivariate analysis, the 9 independent predictors that associated with 30-day mortality were leukopenia, low serum

Adherence rate of quality‐of‐care indicators for Staphylococcus aureus bacteremia is extremely low in Japanese emergency and critical care departments: a multicenter retrospective observational study

“…Previous observational studies have reported a similar mortality rate for SAB (15–40%) as in our study 2, 3, 4, 5, 6, 9, 10. However, the sources of bacteremia differed significantly between studies.…”

“…Previous Japanese observational studies reported an inconsistent rate of pneumonia. One observational study reported a similar rate of pneumonia (17/83, 21%)6 as that reported in the present study, but another study reported a lower rate of pneumonia (4/73, 5%) 7. In contrast, the studies of SAB that were undertaken outside of Japan generally reported a low rate of pneumonia 9, 10.…”

“…In Japan, there have been several small observational studies about SAB, involving fewer than 100 patients 4, 5, 6, 7. These were all single‐center, rather than multicenter studies.…”

Molecular characteristics of methicillin‐resistant Staphylococcus aureus isolated from skin and soft tissue infections collected in the Japanese nationwide surveillance

“…Bacterial DNA extraction and real‐time PCR were performed as reported previously to amplify SCC mec I, SCC mec II‐III, SCC mec I‐II‐IV, toxic shock syndrome toxin 1 genes ( tst ), enterotoxin C genes ( sec ), exfoliative toxin type b genes ( etb ) and pvl . Based on the result of real‐time PCR, the strains were determined as SCC mec types I, II, III, IV and non‐typeable . Based on the SCC mec type, we classified the strains into HA‐MRSA (SCC mec types I, II and III) and CA‐MRSA (SCC mec type IV) …”

“…Skin and soft tissue infections (SSTI) are common in both outpatients and inpatients. Although most methicillin‐resistant Staphylococcus aureus (MRSA) infections are categorized as health‐care‐associated (HA‐MRSA) infections, those caused by community‐associated MRSA (CA‐MRSA), which usually carry staphylococcal cassette chromosome mec (SCC mec ) types IV or V, have been reported from all over the world for over 10 years . However, the molecular characteristics of MRSA isolated from SSTI in Japan remain unclear because there are only a few multicenter studies on molecular epidemiology of MRSA isolated from SSTI in Japan …”