Magnetic resonance imaging of the hand joints in patients with inflammatory bowel disease and arthralgia: a pilot study

Brakenhoff, L.; Stomp, W.; Gaalen, Floris A van; Hommes, Daniël W.; Bloem, Johan L.; Heijde, D.M.F.M. van der; Fidder, Herma H.; Reijnierse, M.

doi:10.3109/03009742.2014.882407

Cited by 5 publications

(3 citation statements)

References 6 publications

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“…On the other hand, if a patient did not present arthritis but only arthralgia during the clinical history, it is unlikely that bone erosions will develop. This is in agreement with previous studies performed on cohorts of patients with inflammatory arthritis and other diseases such as inflammatory bowel disease, in which erosions could not be detected by MRI [26].…”

Section: Discussionsupporting

confidence: 93%

Biomarkers of erosive arthritis in systemic lupus erythematosus: Application of machine learning models

et al. 2018

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ObjectiveLimited evidences are available on biomarkers to recognize Systemic Lupus erythematosus (SLE) patients at risk to develop erosive arthritis. Anti-citrullinated peptide antibodies (ACPA) have been widely investigated and identified in up to 50% of X-ray detected erosive arthritis; conversely, few studies evaluated anti-carbamylated proteins antibodies (anti-CarP). Here, we considered the application of machine learning models to identify relevant factors in the development of ultrasonography (US)-detected erosive damage in a large cohort of SLE patients with joint involvement.MethodsWe enrolled consecutive SLE patients with arthritis/arthralgia. All patients underwent joint (DAS28, STR) and laboratory assessment (detection of ACPA, anti-CarP, Rheumatoid Factor, SLE-related antibodies). The bone surfaces of metacarpophalangeal and proximal interphalangeal joints were assessed by US: the presence of erosions was registered with a dichotomous value (0/1), obtaining a total score (0–20). Concerning machine learning techniques, we applied and compared Logistic Regression and Decision Trees in conjunction with the feature selection Forward Wrapper method.ResultsWe enrolled 120 SLE patients [M/F 8/112, median age 47.0 years (IQR 15.0); median disease duration 120.0 months (IQR 156.0)], 73.3% of them referring at least one episode of arthritis. Erosive damage was identified in 25.8% of patients (mean±SD 0.7±1.6), all of them with clinically evident arthritis. We applied Logistic Regression in conjunction with the Forward Wrapper method, obtaining an AUC value of 0.806±0.02. As a result of the learning procedure, we evaluated the relevance of the different factors: this value was higher than 35% for ACPA and anti-CarP.ConclusionThe application of Machine Learning Models allowed to identify factors associated with US-detected erosive bone damage in a large SLE cohort and their relevance in determining this phenotype. Although the scope of this study is limited by the small sample size and its cross-sectional nature, the results suggest the relevance of ACPA and anti-CarP antibodies in the development of erosive damage as also pointed out in other studies.

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Section: Discussionsupporting

confidence: 93%

Biomarkers of erosive arthritis in systemic lupus erythematosus: Application of machine learning models

et al. 2018

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“…Arthritis is a common finding, and has been reported in 17–39 % of patients with IBD [ 6 ]. We found that the prevalence of joint alterations was as high as 48.8 %, although one magnetic resonance imaging (MRI) study of 11 IBD patients with painful hand joints without clinical synovitis and 11 without painful joints found no signs of synovitis in the latter [ 35 ]. However, the number of patients was small and the study only considered hand joints.…”

Section: Discussionmentioning

confidence: 99%

Hidden musculoskeletal involvement in inflammatory bowel disease: a multicenter ultrasound study

Rovisco

Duarte

Batticcioto

et al. 2016

BMC Musculoskelet Disord

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BackgroundInflammatory bowel diseases are associated with a variety of extra-intestinal manifestations. The most frequent of these is joint involvement, which affects 16–33 % of IBD patients. Our aim was to evaluate the ultrasound prevalence of sub-clinical joint and entheseal involvement in patients with IBD without musculoskeletal symptoms, and to correlate the US findings with clinical and laboratory variables.MethodsWe recorded the clinical and laboratory data of 76 patients with IBD, 20 patients with spondyloarthritis (SpA) and 45 healthy controls at three rheumatology centers. All of the IBD patients and healthy controls were clinically examined by a rheumatologist in order to confirm the absence of musculoskeletal symptoms, and all of the subjects underwent grey-scale (GS) and power Doppler (PD) US examinations of the second and third metacarpophalangeal joints, knees and lower limbs in order to detect joint or entheseal abnormalities.ResultsA total of 1410 entheseal sites and 1410 joints were evaluated by US. Of the 76 patients with IBD, 64 (84.1 %) had at least one GS entheseal abnormality, and 11 (13.9 %) had more than one PD-positive entheseal site; 32 (42.1 %) showed sub-clinical joint involvement.There was a significant difference between the IBD patients and healthy controls in terms of global entheseal, PD-positive entheseal, and joint involvement (p < 0.0001), but no difference between the IBD and SpA patients. Anti-neutrophil cytoplasmic antibodies predicted entheseal involvement in patients with IBD (OR 6.031; p = 0.015).ConclusionsThe prevalence of sub-clinical joint and entheseal involvement was higher in IBD patients than healthy controls, but there was no difference between the IBD and SpA patients.

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“…Interestingly sacroiliac joint alterations were not reported in the majority of examinations (112 [86%], 78 by MRI) [27]. A pilot study involving 11 IBD patients with arthralgia analyzed by hand MRI revealed, in two cases, the presence of enthesitis [28].…”

Section: Sacroiliac Jointmentioning

confidence: 99%

Imaging in the Assessment of Musculoskeletal Manifestations Associated with Inflammatory Bowel Disease

Becciolini

Donato

Lucchini

et al. 2021

Gastroenterology Insights

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Extraintestinal manifestations are the cause of morbidity and affect the quality of life of patients with inflammatory bowel diseases (IBDs). Musculoskeletal manifestations, in particular, spondyloarthritis and osteoporosis, are the most frequent extraintestinal manifestation of IBDs. The diagnosis and management of the musculoskeletal manifestation of IBDs relies on imaging. Conventional radiography, magnetic resonance imaging, computed tomography, and ultrasound can help to detect pathological signs of spondyloarthritis, both peripheral and with axial involvement. Dual-energy X-ray absorptiometry is the gold standard for identifying the presence of osteoporosis, whereas conventional radiology and computed tomography can reveal occult vertebral fractures. The aim of this narrative review is to describe the imaging of musculoskeletal manifestations of IBDs.

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Magnetic resonance imaging of the hand joints in patients with inflammatory bowel disease and arthralgia: a pilot study

Abstract: Several young IBD patients with chronic hand pain had subclinical inflammation on MRI, which invites for further study in a larger group of patients.

Cited by 5 publications

References 6 publications

Biomarkers of erosive arthritis in systemic lupus erythematosus: Application of machine learning models

Biomarkers of erosive arthritis in systemic lupus erythematosus: Application of machine learning models

Hidden musculoskeletal involvement in inflammatory bowel disease: a multicenter ultrasound study

Imaging in the Assessment of Musculoskeletal Manifestations Associated with Inflammatory Bowel Disease

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