Bisphosphonate-Related Osteonecrosis of the Jaw Mimicking Bone Metastasis

Bhatt, Geetika; Bhatt, Aashish D.; Dragun, Anthony E.; Li, Xiaofeng; Civelek, A. Cahid

doi:10.1155/2014/281812

Cited by 8 publications

(6 citation statements)

References 12 publications

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“…There are numerous benign etiologies with a similar scintigraphic appearance as malignant lesions. 29 , 30 Therefore, diagnoses for malignant lesions or metastasis should be performed using multimodal imaging. SPECT and SPECT/CT bone scans are at least twice as sensitive in detecting bone abnormalities, for malignant and benign etiologies.…”

Section: Discussionmentioning

confidence: 99%

A computer program to assess the bone scan index for Tc-99m hydroxymethylene diphosphonate: Evaluation of jaw pathologies of patients with bone metastases using SPECT/CT

Ogawa¹,

Ogura²

2023

Diagn Interv Radiol

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Section: Discussionmentioning

confidence: 99%

A computer program to assess the bone scan index for Tc-99m hydroxymethylene diphosphonate: Evaluation of jaw pathologies of patients with bone metastases using SPECT/CT

Ogawa¹,

Ogura²

2023

Diagn Interv Radiol

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“…Vice versa, it should be kept in mind that BRONJ lesions may mimic malignancy, as in the case presented by Bhatt et al . ( 50 ) in which a patient with metastatic breast cancer on IV alendronate developed a painful mandibular lesion, which was deemed compatible with metastatic focus on the basis of the clinical and imaging features alone and was initially managed with radiation therapy with lack of response; a subsequent biopsy did not show evidence of metastatic disease and a diagnosis of BRONJ was eventually made. Likewise, Pancholi et al .…”

Section: Discussionmentioning

confidence: 99%

Diagnostic challenges in a diffuse large B-cell lymphoma of the maxilla presenting as exposed necrotic bone

Vardas¹,

Georgaki²,

Papadopoulou³

et al. 2022

J Clin Exp Dent

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Lymphoma is the second most common malignancy in the head and neck area, affecting both nodal and extranodal sites, including oral soft and hard tissues, usually in the form of non-Hodgkin’s lymphoma (NHL). However, lymphomas of the jaws, including diffuse large B-cell lymphoma (DLBCL), the most common type of NHL, are very rare and may cause significant diagnostic challenges resembling common jaw pathologies, such as periapical lesions, osteomyelitis and osteonecrosis. The aim of this paper is to present a rare case of DLBCL in an 84-years-old diabetic male patient on methylprednisolone treatment for autoimmune hemolytic anemia. The lesion appeared clinically as exposed necrotic bone of the maxilla with surrounding soft tissue ulceration and radiographically as an extensive osteolytic lesion with ill-defined borders. Despite the resemblance of the lesion with osteonecrosis or osteomyelitis that could be theoretically related to diabetes and/or systemic use of corticosteroids, histopathologic examination, necessitating a repeat biopsy in order to acquire sufficient tissue, revealed the final diagnosis of lymphoma. The need for increased clinical awareness and vigilance of this possible diagnostic conundrum is emphasized. Key words: Diffuse large B-cell lymphoma, exposed bone, oral, malignancy, maxilla, jaw osteonecrosis, differential diagnosis.

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“…27 ). For the differential diagnosis of osteonecrosis of the jaw using bisphosphonate therapy or metastasis to the jaw, the use of SPECT/CT is needed 28 . Unlike the above cited authors, Haraldsen (ref.…”

Section: Detection Of Bone Metastasesmentioning

confidence: 99%

SPECT/CT imaging in breast cancer - current status and challenges

Simanek

Koranda²

2016

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Background. The increasing incidence of breast cancer worldwide raises the importance of improving imaging techniques for disease stratification after early lesion detection. SPECT/CT imaging is now widely available but its diagnostic potential is not fully utilized for more specific purposes including breast cancer patient stratification. Methods and Results. A Pubmed search for both original and review articles related to the value of SPECT/CT in breast cancer patients and comparison to other diagnostic methods. 62 articles were found using the key words SPECT/CT, Fusion Image and Breast Cancer. Development of a new generation of SPECT/CT systems and their introduction into practice has changed the old diagnostic algorithm. The increasing importance of SPECT/CT in the detection of bone metastases is confirmed. The diagnostic accuracy of new SPECT/CT instruments in the diagnostics of bone metastases is nearly comparable to PET/CT scans. SPECT/CT is more widely available and costs less than PET. It is able not only to identify a sentinel lymph nodes in atypical localizations but also to detect sentinel lymph nodes non visualized on previous planar scans. SPECT/CT offers precise anatomic localization of sentinel lymph nodes, thereby facilitating surgery. Knowledge of precise sentinel lymph node localization can also be applied in radiotherapy. Conclusions. The role of hybrid SPECT/CT imaging in breast cancer patients is changing. It is a powerful modality for skeletal and nodal staging in breast cancer patients with important impact on therapy.

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Bisphosphonate-Related Osteonecrosis of the Jaw Mimicking Bone Metastasis

Cited by 8 publications

References 12 publications

A computer program to assess the bone scan index for Tc-99m hydroxymethylene diphosphonate: Evaluation of jaw pathologies of patients with bone metastases using SPECT/CT

A computer program to assess the bone scan index for Tc-99m hydroxymethylene diphosphonate: Evaluation of jaw pathologies of patients with bone metastases using SPECT/CT

Diagnostic challenges in a diffuse large B-cell lymphoma of the maxilla presenting as exposed necrotic bone

SPECT/CT imaging in breast cancer - current status and challenges

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