Optic nerve head drusen: a comparative study of 10 MHz and 20 MHz ultrasound probes

Abstract

The aim of this study was to evaluate and compare 10-MHz and 20-MHz ultrasonography in the assessment of patients with optic nerve head drusen (ONHD). The design of the study was prospective, comparative and cross-sectional. Ultrasonographic examination with a 10 and 20 MHz probe was performed in 45 eyes with suspected ONHD. The 20 MHz probe showed drusen in 43 eyes (95.5 %), while the 10 MHz probe revealed drusen in only 33 eyes (73.3 %, p = 0.0001). The 10 MHz probe showed surface drusen in 10 eyes (22.2 %), while the 20 MHz probe showed surface drusen in 14 eyes (31.1 %) (sensitivity 71.4 %; 95 % CI [47.6-95.1 %]). The 10 MHz probe showed buried drusen in 23 eyes (23.1 %), while the 20 MHz probe showed buried drusen in 29 eyes (64.4 %) (sensitivity 79.3 %; 95 % CI [56.6-86.2 %]). The sensitivity was 76.7 % with 10 MHz probe compared to a 20 MHz as gold standard. The use of 20 MHz probe increased the sensitivity of buried disc drusen by 1.5 times and surface disc drusen by nearly 2 times. Using the 10 MHz probe alone the false negative error rate was 83.3 %. The 20 MHz probe has shown itself to be an excellent method for the diagnosis of ONHD; it is more sensitive and reliable than 10 MHz probe and should be considered in the management of patients with clinical evidence of ONHD.

Understanding Pseudopapilledema on Spectral Domain Optical Coherence Tomography

“…Various imaging techniques have been evaluated to differentiate between papilledema and pseudopapilledema. [6][7][8][9][10][11][12][13][14][15][16][17][18][19] Our study included 48 eyes with a pseudopapilledema with an evidence of ONHD on ultrasound in 44 eyes (in the remaining 4 eyes the ultrasound was not done as the drusens were visible on the optic disc surface).SDOCT using Cirrus machine revealed the ONHD as described by the optic disc drusen consortium only in 39.48% eyes. PHOMS was seen in 64.6% of eyes and the high re ectivity horizontal lines were noted in 39.48% of eyes.…”

An Unusual Presentation of Optic Disc Drusen with Optic Nerve Avulsion

“…B-scan US, a non-invasive diagnostic tool, is a reliable method for confirming the presence of optic disc drusen [7]. CT is also a useful method for diagnosis of optic disc drusen due to their calcium content.…”

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“…Optic nerve drusen is defined as hyaline bodies that result from calcification of intracellular axonal mitochondria located in the prelaminar portion of optic nerve [4]. B-scan US, a non-invasive diagnostic tool, is a reliable method for confirming the presence of optic disc drusen [7]. CT is also a useful method for diagnosis of optic disc drusen due to their calcium content.…”