Clearance of genital warts in pregnant women by mild local hyperthermia: a pilot report

Huo, Wei; Di, Zhenghong; Xiao, Bokui; Qi, Ruiqun; Weiland, Matthew; Gao, Xing‐Hua

doi:10.1111/dth.12066

Cited by 13 publications

(10 citation statements)

References 14 publications

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“…Despite a wide range of treatment being advocated, a meta-analysis of treatment outcomes has shown disappointing clearance rates when compared with placebo 1 . In recent years there have been a number of papers exploring the use of heat as a treatment modality for HPV skin infection 2,3 . Warts heated to around 41° – 44° Celsius have shown increased clearance versus untreated lesions 4 .…”

Section: Introductionmentioning

confidence: 99%

Post marketing surveillance for Microwave Treatment of Plantar and Common Warts in Adults

Bristow

2022

Preprint

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A handheld microwave device (Swift, Emblation Limited) has been licenced and available for clinical use since 2016 in the fields of podiatry and dermatology and has been extensively used in treating cutaneous warts. As part of post marketing surveillance by the manufacturer, an online 79-item survey was distributed to podiatry clinics in the United Kingdom with a Swift device. A total of 126 clinics responded (59.6%). 6998 adults (<65 years) underwent wart treatment with microwave (81.9% plantar warts; 18.1% common, non-plantar warts). The median efficacy rate was reported as 79.2% (65.9 - 87.5%) and 82.3% (71.4 - 100%) respectively. In older adults (over 65 years) efficacy rates were similar for both sites: plantar (73.2%, 50-90%, n=1232) and non-plantar (80.0%, 42.1-100%, n=276). A median of three treatments was required to bring about resolution. Sub-group analysis of the data revealed good clearance rates in patients with diabetes (79.6%), but less in immunocompromised individuals (61.3%) and those with autoimmune disease (58.6%). Overall, mean user satisfaction was rated as very satisfied on a 10-point scale (n=93 practices). A small number of adverse events were reported including blistering, superficial ulceration and poor healing were reported (n=7). Despite the limitations of a post-marketing questionnaire survey, these data provide good evidence of the safety and efficacy for Swift microwave treatment of cutaneous warts.

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Section: Introductionmentioning

confidence: 99%

Post marketing surveillance for Microwave Treatment of Plantar and Common Warts in Adults

Bristow

2022

Preprint

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“…Notably, in a number of immune‐compromised patients, warts have been successfully treated with use of local hyperthermia. In specific, extensive genital warts complicated with diabetes mellitus (Huo, Li, Qi, et al, ) or pregnancy (Huo et al, ), and common warts in a patient with systemic lupus erythematosus (SLE) (Ren, Huo, Qi, et al, ) were effectively treated with hyperthermia. Here, we report a case recently treated for recalcitrant and multifarious warts associated with Cushing's syndrome.…”

Section: Introductionmentioning

confidence: 99%

Local hyperthermia cleared multifarious viral warts in a patient with Cushing's syndrome

Wang

Huang

et al. 2019

Dermatologic Therapy

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A female Cushing's syndrome patient had been suffering from extensive viral warts for months. She was diagnosed with flat warts, common warts and plantar warts. The plantar warts on her right foot were initially treated using local hyperthermia at 44°C for 30 min according to a defined protocol, followed by treatment targeting a common wart on her left thumb. In response to hyperthermia, the flat warts on her eyelid dissipated within 12 weeks, and when combined with a 1 week administration of imiquimod, the common warts and plantar warts completely disappeared within 8 weeks. There were no signs of recurrence and during this treatment her Cushing's syndrome was alleviated. This pioneer trial suggests that local hyperthermia may serve as an effective mean for treating multiple cutaneous warts under the conditions of a systemic immuno‐compromised disease.

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“…Within our clinic we have used local hyperthermia at 44 AE 0.1 C in the treatment of plantar warts and found this procedure to be more effective than that of conventional therapies [5,6]. With this method, we have also successfully alleviated cutaneous warts in patients with diabetes mellitus [7], systemic lupus erythematosus (SLE) [8], Darier disease [9] and pregnancy [10], all of which had experienced failures with conventional treatments.…”

Section: Introductionmentioning

confidence: 99%

DNAJA4 deficiency enhances NF-kappa B-related growth arrest induced by hyperthermia in human keratinocytes

Sun

Ren

Zhang

et al. 2018

Journal of Dermatological Science

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Clearance of genital warts in pregnant women by mild local hyperthermia: a pilot report

Cited by 13 publications

References 14 publications

Post marketing surveillance for Microwave Treatment of Plantar and Common Warts in Adults

Post marketing surveillance for Microwave Treatment of Plantar and Common Warts in Adults

Local hyperthermia cleared multifarious viral warts in a patient with Cushing's syndrome

DNAJA4 deficiency enhances NF-kappa B-related growth arrest induced by hyperthermia in human keratinocytes

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