Auditory rehabilitation after cochlear implantation in adults with hearing impairment after head trauma

Alves, Márcia; Martins, Jorge Humberto; Moura, João; Ramos, Daniela; Alves, Helena; Oliveira, Graça; Magalhães, Isabel; Silva, Luís; Ribeiro, Carlos Fontes; Paiva, António

doi:10.1179/1754762814y.0000000074

Cited by 5 publications

(1 citation statement)

References 6 publications

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“…Hearing levels can deteriorate progressively in closed head injury patients 8 . Similarly, in MiS and RT for vestibular schwannoma (VS), the hearing preservation rates measured within a few years of treatment can be misleading because hearing loss that is unrelated to tumor recurrence continues to progress even after 7 to 8 years [9][10][11][12][13][14] .…”

Section: Introductionmentioning

confidence: 99%

Cell Transplantation to Restore Lost Auditory Nerve Function is a Realistic Clinical Opportunity

Sekiya

Holley

2021

Cell Transplant

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Hearing is one of our most important means of communication. Disabling hearing loss (DHL) is a long-standing, unmet problem in medicine, and in many elderly people, it leads to social isolation, depression, and even dementia. Traditionally, major efforts to cure DHL have focused on hair cells (HCs). However, the auditory nerve is also important because it transmits electrical signals generated by HCs to the brainstem. Its function is critical for the success of cochlear implants as well as for future therapies for HC regeneration. Over the past two decades, cell transplantation has emerged as a promising therapeutic option for restoring lost auditory nerve function, and two independent studies on animal models show that cell transplantation can lead to functional recovery. In this article, we consider the approaches most likely to achieve success in the clinic. We conclude that the structure and biochemical integrity of the auditory nerve is critical and that it is important to preserve the remaining neural scaffold, and in particular the glial scar, for the functional integration of donor cells. To exploit the natural, autologous cell scaffold and to minimize the deleterious effects of surgery, donor cells can be placed relatively easily on the surface of the nerve endoscopically. In this context, the selection of donor cells is a critical issue. Nevertheless, there is now a very realistic possibility for clinical application of cell transplantation for several different types of hearing loss.

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