Are orange lollies effective in preventing nausea and vomiting related to dimethyl sulfoxide? A multicenter randomized trial

Gonella, Silvia; Berchialla, Paola; Bruno, Benedetto; Giulio, Paola Di

doi:10.1007/s00520-014-2227-y

Cited by 8 publications

(11 citation statements)

References 23 publications

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“…The study reporting the highest incidence of nausea had a follow-up period of 5 days 48 , and the authors concluded that the high incidence of nausea observed might be due to the long follow-up period 48 . In another article using the same data 119 , it was suggested that the delayed nausea was due to gastrointestinal mucosal damage, and only the initial nausea could be related to DMSO, and therefore we decided only to include the data from the first 2 days after infusion 48 .…”

Section: Resultsmentioning

confidence: 99%

Adverse reactions of dimethyl sulfoxide in humans: a systematic review

et al. 2019

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Background: Dimethyl sulfoxide (DMSO) has been used for medical treatment and as a pharmacological agent in humans since the 1960s. Today, DMSO is used mostly for cryopreservation of stem cells, treatment of interstitial cystitis, and as a penetrating vehicle for various drugs. Many adverse reactions have been described in relation to the use of DMSO, but to our knowledge, no overview of the existing literature has been made. Our aim was to conduct a systematic review describing the adverse reactions observed in humans in relation to the use of DMSO. Methods: This systematic review was reported according to the PRISMA-harms (Preferred Reporting Items for Systematic reviews and Meta-Analysis) guidelines. The primary outcome was any adverse reactions occurring in humans in relation to the use of DMSO. We included all original studies that reported adverse events due to the administration of DMSO, and that had a population of five or more. Results: We included a total of 109 studies. Gastrointestinal and skin reactions were the commonest reported adverse reactions to DMSO. Most reactions were transient without need for intervention. A relationship between the dose of DMSO given and the occurrence of adverse reactions was seen. Conclusions: DMSO may cause a variety of adverse reactions that are mostly transient and mild. The dose of DMSO plays an important role in the occurrence of adverse reactions. DMSO seems to be safe to use in small doses. Registration: PROSPERO CRD42018096117.

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Section: Resultsmentioning

confidence: 99%

Adverse reactions of dimethyl sulfoxide in humans: a systematic review

et al. 2019

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“…Several odor‐masking strategies have been explored, but data are conflicting (Prior et al, ; Ozdemir et al, ; Potter et al, ; Ndao et al, ). Our recent study (Gonella et al, ) of 69 auto‐HCT patients showed that, although an orange aroma administered as ice lollipops appears to damper the taste of the cryopreservative and the associated nausea, the benefit was due to the cooling rather than the aroma.…”

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confidence: 94%

Potential effects of pleasant and cold stimuli on nausea and vomiting induced by disgusting tastes

Gonella

Dimonte

2016

J of Neuroscience Research

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Several pharmacological agents have disgusting tastes that are perceived strongly in the back of the mouth and may trigger nausea and vomiting (NV), resulting in poor adherence to medication schedules and negative impacts on clinical outcomes. Pleasant stimuli and cold temperature lessen the disgusting stimuli, lowering NV through different mechanisms. A pleasant stimulus can mask an unpleasant one, presumably through lateral inhibitory connections in the local neuronal circuit. Similarly, temperature deeply influences taste perception because the response to bitter as well as to salty and sour has been found to assume a reversed U-shaped form, being reduced by cooling to 18°C and enhanced by warming to 30-37°C. This Review describes the mechanisms by which pleasant and cold stimuli may mask emetogenic disgusting stimuli and identifies the potential clinical applications of cooling for inhibiting objectionable drug-related gustatory reactions. © 2015 Wiley Periodicals, Inc.

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“…The effects of orange aroma are yet to be elucidated. Some previous studies have indicated that orange aroma has psycho‐physiological benefits , but several others have failed to support these assertions . The literature indicates that orange aroma may not be beneficial for stress reduction, and in some cases may even lead to increased stress.…”

Section: Introductionmentioning

confidence: 99%

Alleviation of the acute stress response following mild orange essential oil administration

Lekamge

Nakachi

Sato

et al. 2017

IEEJ Transactions Elec Engng

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We investigated the effect of two different concentrations of orange aroma on peripheral and cardiac autonomic nervous system activity under a stressful condition in a highly reproducible manner. In the within‐subjects experiment, 19 subjects performed a 30‐min calculation task under three aroma conditions: 1% orange, 20% orange, and scentless air (control). Each aroma was delivered to the subject intermittently with the use of a proprietary olfactometer in a counter‐balanced order. Along with a visual analog scale (VAS), nose tip temperature and the cardiac activity on electrocardiograms were recorded throughout the experiment. Regardless of the aroma condition, significant decreases in nose tip temperature and the high‐frequency (HF) component of heart rate variability (HRV) and a significant increase in heart rate (HR) were observed during the task, denoting a typical acute stress response. However, the increase/decrease in HR and HF were significantly smaller with 1% orange than with 20% orange and the control condition, indicating an inhibition of sympathetic nervous system elevation and parasympathetic nervous system suppression. There were no significant differences between the two doses for the VAS scores. The findings suggest that mild orange essential oil inhalation inhibits the cardiac stress response while demonstrating no significant effect on subjective stress. © 2017 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.

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Are orange lollies effective in preventing nausea and vomiting related to dimethyl sulfoxide? A multicenter randomized trial

Cited by 8 publications

References 23 publications

Adverse reactions of dimethyl sulfoxide in humans: a systematic review

Adverse reactions of dimethyl sulfoxide in humans: a systematic review

Potential effects of pleasant and cold stimuli on nausea and vomiting induced by disgusting tastes

Alleviation of the acute stress response following mild orange essential oil administration

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