247. Steroid and triterpenoid saponins: possible spermicidal agents

Banerji, R; Misra, G.; Nigam, S. K.; Singh, Sudarshan; Saxena, R. C.

doi:10.1016/0022-4731(78)90947-0

Cited by 5 publications

(10 citation statements)

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“…The four Lipinski's properties molecular weight (MW), log P, hydrogen bond acceptor (HBA), and hydrogen bond donor (HBD) as well as two additional descriptors topological polar surface area (tPSA) and numbers of rotation bonds of compounds (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15) were calculated by Instant JChem version 17.10.0 from ChemAxon Ltd (Budapest, Hungary) of the molecules and projected onto a drug-like cut-off threshold of Lipinski's rules and Veber's oral bioavailability rule (Figure 8). Lipinski's rule of five, which considers orally active compounds and defines four simple physicochemical parameter ranges (MW ≤ 500, logP ≤ 5, HBD ≤ 5, and HBA ≤ 10) was combined with Veber's oral bioavailability rule, which includes two additional parameter ranges (tPSA ≤ 140 Å, number of rotatable bonds ≤10) [105,106].…”

Section: Rule Of Five and Veber's Oral Bioavailability Rule Of High Fmentioning

confidence: 99%

“…A. arvensis extract has been used in folk remedies for bronchial asthma, fever, and rheumatism [12]. On top of this, anagalligenone sapogenin isolated from A. arvensis caused the instantaneous immobilization of spermatozoa in one minute [13]. The flower extract of C. officinalis, commonly known as marigold [14], has been used to treat HIV and cancer [15,16].…”

Section: Introductionmentioning

confidence: 99%

“…Structures of the dereplicated metabolites from AA (1-5), AL (6-10), and RO(11)(12)(13)(14)(15). glu: β-D-glucose, xyl: β-D-xylose, and ara: α-L-arabinose.…”

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confidence: 99%

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Testicular Caspase-3 and β-Catenin Regulators Predicted via Comparative Metabolomics and Docking Studies

et al. 2020

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Many routes have been explored to search for effective, safe, and affordable alternatives to hazardous female contraceptives. Herbal extracts and their secondary metabolites are some of the interesting research areas to address this growing issue. This study aims to investigate the effects of ten different plant extracts on testicular spermatogenesis. The correlation between the chemical profile of these extracts and their in vivo effect on male reproductive system was evaluated using various techniques. Approximately 10% of LD50 of hydro-methanolic extracts were orally administrated to rats for 60 days. Semen parameters, sexual organ weights, and serum levels of male sex hormones in addition to testes histopathology, were evaluated. Moreover, metabolomic analysis using (LC-HRESIMS), multivariate analysis (PCA), immunohistochemistry (caspase-3 and β-catenin), and a docking study were performed. Results indicated that three plant extracts significantly decreased epididymal sperm density and motility. Moreover, their effects on testicular cells were also assured by histopathological evaluations. Metabolomic profiling of the bioactive plant extracts showed the presence of diverse phytochemicals, mostly oleanane saponins, phenolic diterpenes, and lupane triterpenes. A docking study on caspase-3 enzyme showed that oleanane saponins possessed the highest binding affinity. An immunohistochemistry assay on β-catenin and caspase-3 indicated that Albizzia lebbeck was the most active extract for decreasing immunoexpression of β-catenin, while Rosmarinus officinalis showed the highest activity for increasing immunoexpression of caspase-3. The spermatogenesis decreasing the activity of A. lebbeck, Anagallis arvensis, and R. officinalis can be mediated via up-regulation of caspase-3 and down-regulation of β-catenin existing in testis cells.

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Section: Rule Of Five and Veber's Oral Bioavailability Rule Of High Fmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Testicular Caspase-3 and β-Catenin Regulators Predicted via Comparative Metabolomics and Docking Studies

et al. 2020

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“…[34] Banerji R, et al, 1979 has isolated twelve steroid and triterpenoid saponins from different plant sources including Madhuca longifolia seed as spermicidal agents. [35]…”

Section: Pharmacological Activitymentioning

confidence: 99%

A review on Madhuca longifolia

Kumar¹

2016

RPHS

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Since the beginning of human civilization, medicinal plants have been used by mankind for its therapeutic value. Madhuca longifolia (Family: Sapotaceae), is an Indian tropical tree found largely in the central and north Indian plains and forests. Its common or trade name is Mahwa or Mahua. Various parts of Madhuca longifolia has been used traditionally for different ethnomedicinal purposes. This review enlists the contributions of various scientists on Madhuca longifolia under different sections like ethnomedicinal activity, pharmacological activity, toxicological activity, phytochemistry, insecticidal & pesticidal activity, antimicrobial activity, ethnobotany, clinical studies, miscellaneous, pharmacognosy, analytical and processing techniques, biochemistry and agronomy. This review will provide a path to the researchers to explore the therapeutic potentials of Madhuca lngifolia.

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“…Mekces-Lozoya et al (1990b) reported the hemolytic activity of the raw extracts of the stem bark (Table 4). Triterpenic saponines, the substances considered responsible for this activity, cause membrane rupture in the erythrocytes (Banerji et al, 1981). Studies undertaken in 1992 detected a hemolytic effect in low concentrations of a methanol extract containing alkaloids, and a haemagglutinant effect in high doses (Heinrich et al, 1992).…”

Section: Micrococcus Luteus "mentioning

confidence: 99%