247: Epidemiology and Prevalence of Lung Disease Among E-Cigarette Users in the Usa: A National Study

Kuditipudi, Aasa Deepika; Dirisanala, Sudha; Ganti, Naga; Laller, Srishti; Williams, Inemesit; Taj, Shafaq; Arora, Kunwardeep Singh; Hameed, Ayesha; Lei, Yadanar Win; Venkata, Vikram Samala; Gupta, Sachin; Tirupathi, Raghavendra; Patel, Urvish

doi:10.1097/01.ccm.0000906724.65087.12

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“…A more profound comprehension of the epidemiology and risk factors for LC can guide preventative strategies and reduce the rising disease burden globally [ 5 , 16 ]. E-cigarette, or vaping, products (EVPs) use has been dramatically increasing worldwide, remarkably among younger non-smokers and more females [ 17 , 18 ]. Unfortunately, adults aged 18 to 24 had the highest rate of EVP use, with over 2 million middle and high school students reporting use [ 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Vaping, Environmental Toxicants Exposure, and Lung Cancer Risk

Shehata,

Toraih,

Ismail

et al. 2023

Cancers

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Lung cancer (LC) is the second-most prevalent tumor worldwide. According to the most recent GLOBOCAN data, over 2.2 million LC cases were reported in 2020, with an estimated new death incident of 1,796,144 lung cancer cases. Genetic, lifestyle, and environmental exposure play an important role as risk factors for LC. E-cigarette, or vaping, products (EVPs) use has been dramatically increasing world-wide. There is growing concern that EVPs consumption may increase the risk of LC because EVPs contain several proven carcinogenic compounds. However, the relationship between EVPs and LC is not well established. E-cigarette contains nicotine derivatives (e.g., nitrosnornicotine, nitrosamine ketone), heavy metals (including organometal compounds), polycyclic aromatic hydrocarbons, and flavorings (aldehydes and complex organics). Several environmental toxicants have been proven to contribute to LC. Proven and plausible environmental carcinogens could be physical (ionizing and non-ionizing radiation), chemicals (such as asbestos, formaldehyde, and dioxins), and heavy metals (such as cobalt, arsenic, cadmium, chromium, and nickel). Air pollution, especially particulate matter (PM) emitted from vehicles and industrial exhausts, is linked with LC. Although extensive environmental exposure prevention policies and smoking reduction strategies have been adopted globally, the dangers remain. Combined, both EVPs and toxic environmental exposures may demonstrate significant synergistic oncogenicity. This review aims to analyze the current publications on the importance of the relationship between EVPs consumption and environmental toxicants in the pathogenesis of LC.

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