Targeting interleukin-1β reduces intense acute swimming-induced muscle mechanical hyperalgesia in mice

Borghi, Sérgio M.; Zarpelon, Ana C.; Pinho‐Ribeiro, Felipe A.; Cardoso, Renato D. R.; Cunha, Thiago M.; Alves-Filho, José C.; Ferreira, S. H.; Cunha, Fernando Q.; Casagrande, Rúbia; Verri, Waldiceu A.

doi:10.1111/jphp.12226

Cited by 22 publications

(67 citation statements)

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“…These cytokines are consistent mediators of pain in varied models of inflammation, cancer and neuropathic pain (Borghi et al, 2013, 2014a. TNF-a and IL-1b increase jararhagin-induced mechanical hyperalgesia.…”

Section: Discussionmentioning

confidence: 95%

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Jararhagin-induced mechanical hyperalgesia depends on TNF-α, IL-1β and NFκB in mice

Ferraz

Calixto-Campos

Manchope

et al. 2015

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Jararhagin is a hemorrhagic metalloprotease from Bothrops jararaca snake venom. The hyperalgesic mechanisms of jararhagin were investigated focusing on the role of proinflammatory cytokines (TNF-α and IL-1β) and the transcription factor NFκB. Intraplantar administration of jararhagin (1, 10, 100 and 1000 ng/paw) induced mechanical hyperalgesia, and increased TNF-α levels at 1, 3 and 5 h, and IL-1β levels at 0.5, 1 and 3 h after its injection in the paw tissue. Pre-treatment with morphine (2, 6, 12 μg/paw) inhibited jararhagin-induced mechanical hyperagesia. The systemic or local pre-treatment with etanercept (10 mg/kg and 100 μg/paw) and IL-1ra (30 mg/kg and 100 pg/paw) inhibited jararhagin-induced mechanical hyperalgesia. Co-administration of jararhagin (0.1 ng/paw) and TNF-α (0.1 pg/paw) or jararhagin (0.1 ng/paw) and IL-1β (1 pg/paw) enhanced the mechanical hyperalgesia. The systemic or local pre-treatment with PDTC (NFκB inhibitor; 100 mg/kg and 100 μg/paw) inhibited jararhagin-induced mechanical hyperalgesia as well as PDTC decreased the jararhagin-induced production of TNF-α and IL-1β. Thus, these data demonstrate the involvement of pro-inflammatory cytokines TNF-α and IL-1β and nuclear transcription factor NFκB in jararhagin-induced mechanical hyperalgesia indicating that targeting these mechanisms might contribute to reduce the pain induced by B. jararaca snake venom.

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Section: Discussionmentioning

confidence: 95%

“…injection of carrageenan (300 mg/paw) with sample collection at 3 h was used as a positive control. Doses of treatment were based on previous studies of our group and standardization in our laboratory (Borghi et al, 2014a(Borghi et al, , 2014bCarvalho et al, 2015, Carvalho et al, 2011Ivan et al, 2014).…”

Section: Experimental Protocolsmentioning

confidence: 99%

Jararhagin-induced mechanical hyperalgesia depends on TNF-α, IL-1β and NFκB in mice

Ferraz

Calixto-Campos

Manchope

et al. 2015

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“…It has also been suggested that inhibiting MPO activity reduces muscle pain. tGSH levels are also believed to be maintained in tissues in which anakinra causes an analgesic effect (30).…”

Section: Discussionmentioning

confidence: 99%

The Effect of Anakinra on Paclitaxel-Induced Peripheral Neuropathic Pain in Rats

Kuyrukluyıldız¹,

Küpeli²,

Bedir³

et al. 2017

Turk J Anaesth Reanim

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“…The growing recognition of the benefits of physical activities in human health highlights exercises as an essential conduit for rehabilitation programs in a wide variety of chronic inflammatory diseases such as hypertension, atherosclerosis, heart diseases, diabetes, rheumatoid arthritis and cancer [1]. However, sedentary patients with chronic diseases starting exercise protocols are often more susceptible to experience muscle pain, which may lead to discourage the continuity of exercises sessions resulting in abandonment of exercise practicing and lack of exercise health benefits [1].…”

Section: Introductionmentioning

confidence: 99%

Quercetin Inhibits Peripheral and Spinal Cord Nociceptive Mechanisms to Reduce Intense Acute Swimming-Induced Muscle Pain in Mice

et al. 2016

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The present study aimed to evaluate the effects of the flavonoid quercetin (3,3´,4´,5,7-pentahydroxyflavone) in a mice model of intense acute swimming-induced muscle pain, which resembles delayed onset muscle soreness. Quercetin intraperitoneal (i.p.) treatment dose-dependently reduced muscle mechanical hyperalgesia. Quercetin inhibited myeloperoxidase (MPO) and N-acetyl-β-D- glucosaminidase (NAG) activities, cytokine production, oxidative stress, cyclooxygenase-2 (COX-2) and gp91phox mRNA expression and muscle injury (creatinine kinase [CK] blood levels and myoblast determination protein [MyoD] mRNA expression) as well as inhibited NFκB activation and induced Nrf2 and HO-1 mRNA expression in the soleus muscle. Beyond inhibiting those peripheral effects, quercetin also inhibited spinal cord cytokine production, oxidative stress and glial cells activation (glial fibrillary acidic protein [GFAP] and ionized calcium-binding adapter molecule 1 [Iba-1] mRNA expression). Concluding, the present data demonstrate that quercetin is a potential molecule for the treatment of muscle pain conditions related to unaccustomed exercise.

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Targeting interleukin-1β reduces intense acute swimming-induced muscle mechanical hyperalgesia in mice

Abstract: IL-1β mediates intense acute swimming-induced muscle mechanical hyperalgesia by peripheral (soleus muscle) and spinal cord integrative mechanisms and could be considered a potential target to treat exercise-induced muscle pain.

Cited by 22 publications

References 65 publications

Jararhagin-induced mechanical hyperalgesia depends on TNF-α, IL-1β and NFκB in mice

Jararhagin-induced mechanical hyperalgesia depends on TNF-α, IL-1β and NFκB in mice

The Effect of Anakinra on Paclitaxel-Induced Peripheral Neuropathic Pain in Rats

Quercetin Inhibits Peripheral and Spinal Cord Nociceptive Mechanisms to Reduce Intense Acute Swimming-Induced Muscle Pain in Mice

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