Human Papilloma Viruses (HPVs) no Co-Existence in Breast Cancer and Cervical Cells in the Same Patient

Lv, Yanrong; Wang, Jianli; Zhang, Kai; Gao, Haidong; Sun, Jia; Gong, Yun; Ma, Rong

doi:10.4077/cjp.2014.bac207

Cited by 6 publications

(6 citation statements)

References 4 publications

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“…Sexual transmission is the generally accepted transmission route, though it is not the only route, since transmission could occur by hand from the female perineum to the breast, wich could occur during sexual activity or even showering or bathing [8, 11, 68–70]. In an attempt to identify the possible origin of HPV in the breast, a number of authors [71–74] have explored the possible relationship between presence of the virus in the breast and cervical disease produced by HPV. Based on their studies it is not possible to conclude that HPV of the breast originates from the cervix.…”

Section: Discussionmentioning

confidence: 99%

Presence of human papillomavirus DNA in breast cancer: a Spanish case-control study

Delgado-García

Martínez‐Escoriza

Alba³

et al. 2017

BMC Cancer

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BackgroundBreast cancer is one of the most important neoplasia among women. It was recently suggested that biological agents could be the etiological cause, particularly Human Papilloma Virus (HPV). The aim of this study was to explore the presence of HPV DNA in a case-control study.MethodsWe performed our study including 251 cases (breast cancer) and 186 controls (benign breast tumors), using three different molecular techniques with PCR (GP5/GP6, CLART® and DIRECT FLOW CHIP®).ResultsHPV DNA was evidenced in 51.8% of the cases and in 26.3% of the controls (p < 0.001). HPV-16 was the most prevalent serotype. The odds ratio (OR) of HPV within a multivariate model, taking into account age and breastfeeding, was 4.034.ConclusionsOur study, with methodological rigour and a sample size not previously found in the literature, demonstrate a significant presence of HPV DNA in breast cancer samples. A possible causal relationship, or mediation or not as a cofactor, remains to be established by future studies.

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Section: Discussionmentioning

confidence: 99%

Presence of human papillomavirus DNA in breast cancer: a Spanish case-control study

Delgado-García

Martínez‐Escoriza

Alba³

et al. 2017

BMC Cancer

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“…On the contrary, Lv et al . [42] failed to find coexistence of HPV in breast or cervical tissues of 12 cases. In our study, there was no case of HPV coexistence in cervical lesion or breast cancer.…”

Section: Discussionmentioning

confidence: 99%

Detection of Human Papillomavirus in Korean Breast Cancer Patients by Real-Time Polymerase Chain Reaction and Meta-Analysis of Human Papillomavirus and Breast Cancer

Choi¹,

Kim²,

Lee³

et al. 2016

J Pathol Transl Med

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BackgroundHuman papillomavirus (HPV) is a well-established oncogenic virus of cervical, anogenital, and oropharyngeal cancer. Various subtypes of HPV have been detected in 0% to 60% of breast cancers. The roles of HPV in the carcinogenesis of breast cancer remain controversial. This study was performed to determine the prevalence of HPV-positive breast cancer in Korean patients and to evaluate the possibility of carcinogenic effect of HPV on breast.MethodsMeta-analysis was performed in 22 case-control studies for HPV infection in breast cancer. A total of 123 breast cancers, nine intraductal papillomas and 13 nipple tissues of patients with proven cervical HPV infection were tested by real-time polymerase chain reaction to detect 28 subtypes of HPV. Breast cancers were composed of 106 formalin-fixed and paraffin embedded (FFPE) breast cancer samples and 17 touch imprint cytology samples of breast cancers.ResultsThe overall odds ratio between breast cancer and HPV infection was 5.43 (95% confidence interval, 3.24 to 9.12) with I² = 34.5% in meta-analysis of published studies with case-control setting and it was statistically significant. HPV was detected in 22 cases of breast cancers (17.9%) and two cases of intaductal papillomas (22.2%). However, these cases had weak positivity.ConclusionsThese results failed to serve as significant evidence to support the relationship between HPV and breast cancer. Further study with larger epidemiologic population is merited to determine the relationship between HPV and breast cancer.

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“…Using of these specimens and data in research was approved by the Ethics Committee of Gaziantep University. In the study, paraffin blocks were melted and examined by molecular method (PCR) to determine the DNA of high risk HPV genotypes (16,18,31,33,35,39,45,51,52,56,58,59, 66 and 68). We also examined 13 cases of cervical cancer as a control for this study.…”

Section: Methodsmentioning

confidence: 99%

“…Specifically, this study aims to determine the presence of High-risk (HR) HPV (16,18,31,33,35,39,45,51,52,56,58,59, 66 and 68) genotypes in samples obtained from breast cancers at the University Hospital of Gaziantep (Turkey) using Real Time (RT) PCR approaches.…”

Section: Investigation Of the Relationship Between Breast Cancers Andmentioning

confidence: 99%

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Investigation of the Relationship between Breast Cancers ‎and HPVs

Saeed¹,

Zer²,

Bozdağ³

2018

ujcm

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High-risk human papillomaviruses (HR-HPVs) have been implicated in the aetiology of a variety of human cancers, including cervical, colorectal, and head and neck (HN); also, (HPVs) may be important risk factors for breast carcinogenesis and metastasis. Previous studies that evaluated the prevalence of HPVs in breast cancer have generated considerable controversy. Based on this hypothesis, we aimed to investigate the prevalence of HPV infection in invasive breast cancer tissues. Our study included 80 paraffin blocks taken from breast cancerous tissue specimens of Turkish female patients and 13 controls (cervical cancerous tissue specimens) in Research and Practice Hospital-Sahinbey-Gaziantep University, using PCR (HPV Genotypes 14 Real-TM Quant / Italy) to detect the HR-HPV DNA. In our results: HR-HPV DNA was evidenced in (10%) of the breast cancer and in (92.3 %) of the controls (p < 0.05). HPV (45-56-68) were the most prevalent genotypes in breast cancer cases. Also HPV co-infection was high (75%) in positive breast cancerous samples. Our data propose Human papilloma viruses may play a role as a possible causal relationship, or mediation or even as a cofactor in the development of some types of breast cancer, this still needs to be confirmed by prospective studies.

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Human Papilloma Viruses (HPVs) no Co-Existence in Breast Cancer and Cervical Cells in the Same Patient

Cited by 6 publications

References 4 publications

Presence of human papillomavirus DNA in breast cancer: a Spanish case-control study

Presence of human papillomavirus DNA in breast cancer: a Spanish case-control study

Detection of Human Papillomavirus in Korean Breast Cancer Patients by Real-Time Polymerase Chain Reaction and Meta-Analysis of Human Papillomavirus and Breast Cancer

Investigation of the Relationship between Breast Cancers ‎and HPVs

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