Working memory network plasticity after anterior temporal lobe resection: a longitudinal functional magnetic resonance imaging study

Stretton, Jason; Sidhu, M.; Winston, Gavin P.; Bartlett, Philippa A.; McEvoy, Andrew W.; Symms, Mark R.; Koepp, Matthias J.; Thompson, Pamela J.; Duncan, John S.

doi:10.1093/brain/awu061

Cited by 35 publications

(40 citation statements)

References 60 publications

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“…The lack of clear lateralization in amygdala reactivity to faces does not rule out the possibility that the left and right amygdala can modulate core face processing areas differently, an idea that would fit the present observation. The observed group differences are also in line with a previous fMRI study on working memory in patients with ATR, which also found different activation patterns in left and right resected patients (Stretton et al, 2014). The more widespread reductions in neural reactivity in patients with right ATR did however not correspond to behavior, because the accuracy in face matching did not differ between patients with right and left sided resection.…”

Section: Discussionsupporting

confidence: 89%

“…As in our ROI-analysis, the reductions in the right resected group were more widespread than in the left resected group. Previous neuroimaging studies of face processing have also found activations in the superior parietal cortex (Stretton et al, 2014), motor areas (Kilts, Egan, Gideon, Ely, & Hoffman, 2003) and the striatum (Fusar-Poli et al, 2009). Our findings suggest that face-related activity in these areas is modulated by the MTL.…”

Section: Discussionmentioning

confidence: 93%

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Medial temporal lobe resection attenuates superior temporal sulcus response to faces

et al. 2014

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 93%

Medial temporal lobe resection attenuates superior temporal sulcus response to faces

et al. 2014

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“…According to this concept, regions or circuits within the brain are able to counteract and/or counterbalance age-related alterations or disease pathologies by reorganizing synaptic structure, connections, and ultimately function via a multitude of molecular and cellular pathways (Honer et al, 2012). A primary example of this form of neuroplasticity is found in the hippocampus, a major component of the limbic system that displays neural reorganization after brain injury in animal models of neural damage and in human neurological diseases including epilepsy (Stretton et al, 2014) and AD (DeKosky et al, 2002; Davis et al, 1999). Therefore, the overall goal of this review is to present evidence derived from clinical pathological investigations that the hippocampus, a component of the medial temporal lobe (MTL) memory circuit, displays cellular and structural alterations indicative of neural plasticity during the progression of AD.…”

mentioning

confidence: 99%

Hippocampal plasticity during the progression of Alzheimer’s disease

et al. 2015

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Neuroplasticity involves molecular changes in central nervous system (CNS) synaptic structure and function throughout life. The concept of neural organization allows for synaptic remodeling as a compensatory mechanism to the early pathobiology of Alzheimer’s disease (AD) in an attempt to maintain brain function and cognition during the onset of dementia. The hippocampus, a crucial component of the medial temporal lobe memory circuit, is affected early in AD and displays synaptic and intraneuronal molecular remodeling against a pathological background of extracellular amyloid-beta (Aβ) deposition and intracellular neurofibrillary tangle (NFT) formation in the early stages of AD. Here we discuss human clinical pathological findings supporting the concept that the hippocampus is capable of neural plasticity during mild cognitive impairment (MCI), a prodromal stage of AD and early stage AD.

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“…However, the benefit of epilepsy surgery must be weighed against the risk of cognitive decline, which is commonly observed in the domains of language and long‐term memory . Conversely, postsurgical gains in executive domains such as attention and working memory can be observed . Clinical (e.g., epilepsy duration, presurgical cognitive level) and demographic (e.g., age) factors predict postsurgical cognitive outcomes .…”

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confidence: 99%

The corpus callosum and recovery of working memory after epilepsy surgery

et al. 2015

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SUMMARYObjective: For patients with medically intractable focal epilepsy, the benefit of epilepsy surgery must be weighed against the risk of cognitive decline. Clinical factors such as age and presurgical cognitive level partially predict cognitive outcome; yet, little is known about the role of cross-hemispheric white matter pathways in supporting postsurgical recovery of cognitive function. The purpose of this study is to determine whether the presurgical corpus callosum (CC) midsagittal area is associated with pre-to postsurgical change following epilepsy surgery. Methods: In this observational study, we retrospectively identified 24 adult patients from an epilepsy resection series who completed preoperative high-resolution T 1 -weighted magnetic resonance imaging (MRI) scans, as well as pre-and postsurgical neuropsychological testing. The total area and seven subregional areas of the CC were measured on the midsagittal MRI slice using an automated method. Standardized indices of auditory-verbal working memory and delayed memory were used to probe cognitive change from pre-to postsurgery. CC total and subregional areas were regressed on memory-change scores, after controlling for overall brain volume, age, presurgical memory scores, and duration of epilepsy. Results: Patients had significantly reduced CC area relative to healthy controls. We found a positive relationship between CC area and change in working memory, but not delayed memory; specifically, the larger the CC, the greater the postsurgical improvement in working memory (b = 0.523; p = 0.009). Effects were strongest in posterior CC subregions. There was no relationship between CC area and presurgical memory scores. Significance: Findings indicate that larger CC area, measured presurgically, is related to improvement in working memory abilities following epilepsy surgery. This suggests that transcallosal pathways may play an important, yet little understood, role in postsurgical recovery of cognitive functions.

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Working memory network plasticity after anterior temporal lobe resection: a longitudinal functional magnetic resonance imaging study

Cited by 35 publications

References 60 publications

Medial temporal lobe resection attenuates superior temporal sulcus response to faces

Medial temporal lobe resection attenuates superior temporal sulcus response to faces

Hippocampal plasticity during the progression of Alzheimer’s disease

The corpus callosum and recovery of working memory after epilepsy surgery

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