Emodin-mediated cross-linking enhancement for extracellular matrix homeostasis

Jian, Lihua; Zhang, Chen; Chen, Guangfeng; Shi, Xiujuan; Qiu, Yue; Xue, Yunyun; Yang, Shao Nian; Lü, Lixia; Yuan, Qionglan; Xu, Guo‐Tong; Ying, Ming; Liu, Xiaoqing

doi:10.1016/j.bbrc.2014.03.052

Cited by 4 publications

(2 citation statements)

References 21 publications

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“…Another recent study utilized a reporter system controlled by the LOXL1 promoter to screen for drugs that exert effects on this promoter 56 . Emodin was found to have strong enhancer effects on the LOXL1 promoter in this drug screen.…”

Section: Loxl1 Variants and Xfs/xfgmentioning

confidence: 99%

Genetics of Exfoliation Syndrome and Glaucoma

Aboobakar¹,

Allingham²

2014

International Ophthalmology Clinics

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Exfoliation glaucoma (XFG) is the most common identifiable secondary form of open-angle glaucoma in the world. It is an ocular manifestation of exfoliation syndrome (XFS), an age-related systemic disease characterized by deposition of extracellular fibrillar material in various tissues and organs. XFS/XFG has been studied in populations around the world, which has led to identification of genetic factors that play a significant role in disease pathogenesis. Here, we summarize current knowledge of the genetics of XFS/XFG and identify areas for future research.

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Section: Loxl1 Variants and Xfs/xfgmentioning

confidence: 99%

Genetics of Exfoliation Syndrome and Glaucoma

Aboobakar¹,

Allingham²

2014

International Ophthalmology Clinics

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“…Cross-linking formation play a critical role in ECM formation and homeostasis. Emodin was found to be a strong enhancer of LOXL1 expression that promotes ECM cross-linking formation by using the ZsGreen reporter system for drug screening, suggesting that emodin may be an effective drug or complement to ECM homeostasis ( Jian et al, 2014 ).…”

Section: Natural Products Normalize Ecmmentioning

confidence: 99%

Targeting extracellular matrix through phytochemicals: a promising approach of multi-step actions on the treatment and prevention of cancer

Liang

Zhao

et al. 2023

Front. Pharmacol.

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Extracellular matrix (ECM) plays a pivotal and dynamic role in the construction of tumor microenvironment (TME), becoming the focus in cancer research and treatment. Multiple cell signaling in ECM remodeling contribute to uncontrolled proliferation, metastasis, immune evasion and drug resistance of cancer. Targeting trilogy of ECM remodeling could be a new strategy during the early-, middle-, advanced-stages of cancer and overcoming drug resistance. Currently nearly 60% of the alternative anticancer drugs are derived from natural products or active ingredients or structural analogs isolated from plants. According to the characteristics of ECM, this manuscript proposes three phases of whole-process management of cancer, including prevention of cancer development in the early stage of cancer (Phase I); prevent the metastasis of tumor in the middle stage of cancer (Phase II); provide a novel method in the use of immunotherapy for advanced cancer (Phase III), and present novel insights on the contribution of natural products use as innovative strategies to exert anticancer effects by targeting components in ECM. Herein, we focus on trilogy of ECM remodeling and the interaction among ECM, cancer-associated fibroblasts (CAFs) and tumor-associated macrophages (TAMs), and sort out the intervention effects of natural products on the ECM and related targets in the tumor progression, provide a reference for the development of new drugs against tumor metastasis and recurrence.

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The role of lysyl oxidase-like 1 (LOXL1) in exfoliation syndrome and glaucoma

Schlötzer‐Schrehardt

Zenkel

2019

Experimental Eye Research

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Emodin-mediated cross-linking enhancement for extracellular matrix homeostasis

Cited by 4 publications

References 21 publications

Genetics of Exfoliation Syndrome and Glaucoma

Genetics of Exfoliation Syndrome and Glaucoma

Targeting extracellular matrix through phytochemicals: a promising approach of multi-step actions on the treatment and prevention of cancer

The role of lysyl oxidase-like 1 (LOXL1) in exfoliation syndrome and glaucoma

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