Caffeine Intake and Atrial Fibrillation Incidence: Dose Response Meta-analysis of Prospective Cohort Studies

Does Caffeine Consumption Increase the Risk of New-Onset Atrial Fibrillation?

“…Previous meta-analyses looking at the relationship between caffeine intake and AF risk showed no overall association [10,19,20]. In the most recent meta-analysis, coffee consumption was associated with a nonsignificant positive association in men, but with a nonsignificant inverse association in women [10].…”

“…In the most recent meta-analysis, coffee consumption was associated with a nonsignificant positive association in men, but with a nonsignificant inverse association in women [10]. In another meta-analysis, after adjusting for smoking, a statistically significant inverse association was found between caffeine intake and AF in a subgroup analysis of 4 studies [20]. In the meta-analysis by Caldeira et al [19], including 6 prospective studies and 1 case-control study, low caffeine intake but not moderate and high intakes were associated with a relatively reduced risk of AF.…”

“…Bhave and Hoffmayer [32] underscored the importance of performing a randomized controlled clinical trial to assess the impact of caffeine by using a more easily standardized form of caffeine (i.e., pills). Most importantly, further investigation is needed to understand the cardioprotective effect of coffee, independent of caffeine and secondary to other bioactive phytochemicals [20] and whether we are more sensitive to higher coffee as opposed to higher caffeine intake [10]. Most recently, Voskoboinik et al [33] have published a comprehensive review supporting our conclusions that caffeine consumption does not increase the incidence of AF but, in fact, consumption of up to 3 cups of coffee daily may reduce the incidence of AF.…”

Lifestyle Modification in the Prevention and Treatment of Atrial Fibrillation

“…A recent meta-analysis of 6 prospective cohort studies with 228,465 individuals showed a trend towards caffeine consumption being associated with AF risk reduction (RR, 0.90; 95% CI, 0.81-1.01; P = 0.07) 101 . However, subgroup analysis demonstrated an 11% reduction in AF risk with low doses of caffeine consumption (P= 0.032) and a 16% reduction for high doses (P= 0.002).…”

Caffeine Consumption and Atrial Fibrillation: A Risk Assessment

“…The odds ratio (95% confidence interval) of low-dose caffeine for AF was 0.85 (range 0.78–0.92), and relatively higher caffeine exposure showed no significant risk for AF. Cheng et al [3] also conducted a meta-analysis to evaluate the association between chronic exposure of caffeine and the risk of AF. The relative risk (95% confidence interval) of low-dose caffeine for incident AF was 0.89 (range 0.80–0.99).…”