Treatment of mild and moderate type-2 diabetes: open prospective trial with Hintonia latiflora extract

Abstract

BackgroundExtracts from the bark of Hintonia latiflora are used as dietetic measures to support the regulation of glucose metabolism and the stabilization of blood glucose values.MethodsA dry concentrated extract from the bark of Hintonia latiflora in capsule form was tested in an open, prospective clinical study in 41 dietetically stabilized subjects with type 2 diabetes. The effects on parameters of blood glucose control were documented over a period of six months.ResultsFasting and postprandial glucose and the HbA1c value declined significantly. In the case of HbA1c, this meant a reduction of the absolute value from 7.49 ± 0.72% to 6.82 ± 0.67% (from 58.4 to 51.0 mmol/mol Hb; intention to treat (ITT) population). Furthermore, cholesterol and triglycerides were slightly reduced and no negative effect on other laboratory parameters and no change of the liver values were observed. Tolerance was very good. In particular, no side effects and no hypoglycemic episodes or worsening of diabetic symptoms occurred.ConclusionsThe study confirms the positive effect of extracts from the bark of Hintonia latiflora on blood glucose values suggesting a potential benefit in the management of glucose metabolism in cases of type 2 diabetes.Trial registrationReg.-No. ISRCTN83308122

Comparison and Effectiveness of Complementary and Alternative Medicine as against Conventional Medicine in the Treatment and Management of Type 2 Diabetes

“…Several Randomized controlled trials demonstrating a benefit on lipid parameters in diabetes include Ayurvedic polyherbal formulation [14], Hintonia latiflora [15] and magnesium [16]. In postmenopausal women with type 2 diabetes, vitamin D supplementation for 6 months reduced serum triglycerides (TG) without effect on other lipid parameters [17], while a meta-analysis with high heterogeneity showed benefit on lowering total cholesterol and TG [18].…”

Complementary and Alternative Medicine for Diabetes

“…• Ayurveda polyherbal formulation (19) • Citrullus colocynthis (20) • Coccinia cordifolia (21) • Eicosapentaenoic acid (22) • Ganoderma lucidum (23) • Ginger (Zingiber officinale) (24) • Gynostemma pentaphyllum (25) • Hintonia latiflora (26) • Lichen genus Cladonia BAFS "Yagel-Detox" (27) • Marine collagen peptides (28) • Nettle (Urtica dioica) (29) • Oral aloe vera (10) • Pterocarpus marsupium (vijayasar) (30) • Salacia reticulata (31) • Scoparia dulcis porridge (32) • Silymarin (33,34) • Soybean-derived pinitol extract (35) • Touchi soybean extract (36) • Traditional Chinese medicine herbs:…”

“…Randomized controlled trials demonstrating a benefit on lipid parameters in diabetes include: Ayurvedic polyherbal formulation (19), Hintonia latiflora (26) and magnesium (99). In postmenopausal women with type 2 diabetes, vitamin D supplementation for 6 months reduced serum triglycerides (TG) without effect on other lipid parameters (141), while a meta-analysis with high heterogeneity showed benefit on lowering total cholesterol and TG (142).…”

Research progress of coumarins and their derivatives in the treatment of diabetes

“…Positive effects of preparations of the bark of the Central American plant Hintonia latiflora (family Rubiaceae) on blood glucose reduction and therefore the maintenance of physiologically normal blood glucose values have been reported 84–86 . Jose et al.…”