Active ingredients against human epidermal aging

Lorencini, Márcio; Brohem, Carla Abdo; Dieamant, Gustavo; Zanchin, Nilson Ivo Tonin; Maibach, Howard I.

doi:10.1016/j.arr.2014.03.002

Cited by 117 publications

(104 citation statements)

References 233 publications

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“…Besides the well-known compounds (vitamins C, E, beta-carotene etc), phenolics with documented antioxidative properties gained great interest being added to diet or used for topical applications (Lorencini M et al, 2014;Robbins, 2003). Biomaterials based on nanoparticles and natural extracts were tested recently as antiinflammatory agents, beneficial in treating skin diseases (David et al, 2014;Wu et al, 2015).…”

Section: Morphology Analysismentioning

confidence: 99%

Modulation of the UV-B-induced Oxidative Stress and Apoptosis in HaCaT Cell Line with <i>Calluna vulgaris</i> Extract

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Burz

et al. 2015

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The reactive oxygen species (ROS) production due to ultraviolet B (UV-B) exposure is extremely harmful to the skin. It causes lesions of DNA, proteins and lipids and leads to cellular death. In the present study the UV-B-induced ROS and subsequent apoptosis in the human keratinocyte cell line (HaCaT) were counterbalanced by a plant extract with antioxidant capacity. Some molecules modulated by common heather (Calluna vulgaris) (CV) extract through which this may exert its photoprotective effects were also identified. The ROS were evaluated with CM-H2DCFDA assay, while apoptosis and Bax-α/Bcl-xL molecules with ELISA. The extract was standardized according to its polyphenolic content and the most important biologically active compounds, such as hyperozid, quercetin, isoquercetin, kampferol were evidenced by high-performance liquid chromatography. The UV-B induced ROS production occurred at its highest level at 2 h after the exposure of the HaCaT cells, while apoptosis later, at 4 h. The most significant changes in Bax-α and Bcl-XL proteins induced by UV-B, as well as the highest effect of the extract on apoptosis, were both registered at 4 h. The CV extract decreased concentration-and time-dependently the UV-B-induced ROS production and prevented apoptosis. These effects of CV occurred, at least to a certain extent, due to the modulation of Bax-α/Bcl-XL proteins. These findings suggest that skin cells could be protected from some of the UV-B-induced harmful effects by the administration of the CV extract, which may be further exploited as a potential photoprotective agent.

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Section: Morphology Analysismentioning

confidence: 99%

Modulation of the UV-B-induced Oxidative Stress and Apoptosis in HaCaT Cell Line with <i>Calluna vulgaris</i> Extract

Virág

Brie

Burz

et al. 2015

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“…The identification of new biological mechanisms associated with skin aging and continuous discoveries of new acting forms of compounds which can prevent the appearance of or recover the signs of aging are two fronts, which cooperate for these advances in knowledge 2 .…”

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confidence: 99%

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2018

IJPSR

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Photochemoprotection has nowadays become inevitable to combat aging. Exposure to Ultraviolet radiations accelerates skin aging which eventually culminates in wrinkles, laxity, dyspigmentation, roughness and dryness. Though many active synthetic topicals have been used since years, the present era of treating an aged skin has been diverted towards natural biomaterials as these synthetic topicals pose health and safety risk on human health. In an effort to produce a promising natural anti-aging agent in contemporary cosmetics, this study has been aimed to formulate an anti-aging gel by blending three biopolymers namely Collagen (COL) 3%w/v, Chitosan (CS) 1.5% w/v and Aloe vera (AV) gel 0.21% w/v. The AV blended COL-CS gel was characterized by spreadability and moisture uptake test, which indicated good spreadability and increased hydrophyllicity of the gel. Cell culture studies on NIH3T3 mouse fibroblasts cells were carried out using senescenceassociated-β-gal [SA-β-gal] as a biomarker. The fibroblasts cells on incubation with AV blended COL-CS gel showed increased proliferation rate and the absence of blue stain indicated that the process of senesce has been reversed. In conclusion, the prepared AV blended COL-CS gel helps in regeneration and rejuvenation of the skin and therefore can be used as a promising anti-aging gel.

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“…A biológiai rendszer rendszeralgoritmusai is megváltoznak az élettartam emelkedésével, amelyek az ismert gerontológiai események feltárásával kerültek igazolásra. Így a környezetterhelésekkel megváltoztatott feltételen egy már módosult (lelassult, és alacsonyabb komplexitási kapacitású) működést prezentáló rendszernek kell a homeosztatikus egyensúlyt fenntartani [36,37]. Az, hogy a daganatos betegségek incidenciája és prevalenciája idősebb korban igazoltan kifejezettebb, a vázolt okokkal is magyarázható [34].…”

Section: Környezeti Alkalmazkodási Potenciál Csökkenés éS Egyes Biolóunclassified

“…öregedés [36,37]) és/vagy annak környezetében (környezetterhelések [5,6,7]) változások jelennek meg. Az említett változások lehetnek erőteljesek [32] és/vagy egyszerre több helyen kialakulók [33], amelyek következtében az alkalmazkodási kapacitás az adott organizmus esetében csökken, esetleg egy kritikus küszöbértéket is elér [4], ami következményesen a rendszer viselkedésének és/vagy állapotciklusának megváltozását indukálja.…”

Section: Megbeszélésunclassified

A környezeti terhelések és patomechanizmusok kapcsolata

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Active ingredients against human epidermal aging

Cited by 117 publications

References 233 publications

Modulation of the UV-B-induced Oxidative Stress and Apoptosis in HaCaT Cell Line with <i>Calluna vulgaris</i> Extract

Modulation of the UV-B-induced Oxidative Stress and Apoptosis in HaCaT Cell Line with <i>Calluna vulgaris</i> Extract

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A környezeti terhelések és patomechanizmusok kapcsolata

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