Seven novel <scp>MHC</scp> class I alleles identified in <i>Cercopithecus mitis</i>

The major histocompatibility complex (MHC) is central to the innate and adaptive immune responses of jawed vertebrates. Characteristic of the MHC are high gene density, gene copy number variation, and allelic polymorphism. Because apes and monkeys are the closest living relatives of humans, the MHCs of these non-human primates (NHP) are studied in depth in the context of evolution, biomedicine, and conservation biology. The Immuno Polymorphism Database (IPD)-MHC NHP Database (IPD-MHC NHP), which curates MHC data of great and small apes, as well as Old and New World monkeys, has been upgraded. The curators of the database are responsible for providing official designations for newly discovered alleles. This nomenclature report updates the 2012 report, and summarizes important nomenclature issues and relevant novel features of the IPD-MHC NHP Database. Keywords MHC . NHP . Database . Nomenclature . IPD Natasja G. de Groot and Nel Otting contributed equally to this work. This article is part of the Topical Collection on "Nomenclature, databases and bioinformatics in Immunogenetics" Natasja G. de Groot, Nel Otting, and Ronald E. Bontrop are curators of the IPD-MHC NHP database.

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Nomenclature report 2019: major histocompatibility complex genes and alleles of Great and Small Ape and Old and New World monkey species

Groot

Otting

Maccari

et al. 2019

Immunogenetics

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Seven novel MHC class I alleles identified in Cercopithecus mitis

Abstract: We report here the identification of three Cemi-A and four Cemi-B novel alleles of Cercopithecus mitis.

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Nomenclature report 2019: major histocompatibility complex genes and alleles of Great and Small Ape and Old and New World monkey species

Nomenclature report 2019: major histocompatibility complex genes and alleles of Great and Small Ape and Old and New World monkey species

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