“…In the brain, 2-AG is the dominant endocannabinoid (Alger and Kim, 201), and its best-known actions are as a retrograde messenger, traversing the postsynaptic cell membrane to activate G i/o protein-coupled cannabinoid type 1 (CB 1 ) receptors at presynaptic terminals and produce suppression of neurotransmitter release (Kreitzer and Regehr, 2001; Ohno-Shosaku et al, 2001; Wilson and Nicoll, 2001). In some neurons, 2-AG can reduce excitability by cell-autonomous actions mediated by receptors in the postsynaptic membrane, via CB 1 (Bacci et al, 2004; Marinelli et al, 2008; 2009), or CB 2 receptors (den Boon et al, 2014, Stempel et al, 2016). Most neuronal actions of 2-AG require CB receptors, with CB 1 receptors mediating the vast majority of actions in the brain (Lu and Mackie, 2016).…”