Effects of Nardostachys chinensis on Spontaneous Ventricular Arrhythmias in Rats With Acute Myocardial Infarction

Zhang, Jing; Qiang, Can-Can; Li, Weijie; Liu, Lijuan; Lin, Xuemei; Cheng, Yun‐Jiu; Tang, Kai; Yao, Fengjuan; Wu, Shan

doi:10.1097/fjc.0000000000000096

Cited by 12 publications

(16 citation statements)

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“…We included 16 studies in this review [ 19 – 34 ]. Among them, 12 studies were published in Chinese journals, [ 19 , 23 , 24 , 26 – 34 ] and 4 studies were published in English-language journals [ 20 – 22 , 25 ]. Five studies were associated with animal experiments [ 19 , 20 , 23 – 25 ], and 11 studies were related to cell experiments [ 21 , 22 , 26 – 34 ].…”

Section: Resultsmentioning

confidence: 99%

“…Among them, 12 studies were published in Chinese journals, [ 19 , 23 , 24 , 26 – 34 ] and 4 studies were published in English-language journals [ 20 – 22 , 25 ]. Five studies were associated with animal experiments [ 19 , 20 , 23 – 25 ], and 11 studies were related to cell experiments [ 21 , 22 , 26 – 34 ]. 4 studies reflected the reported cardioprotective effects of NC [ 19 – 22 ], including 2 studies based on cell experiments [ 19 , 20 ] and 2 studies based on animal experiments [ 21 , 22 ].…”

Section: Resultsmentioning

confidence: 99%

“…4 studies reflected the reported cardioprotective effects of NC [ 19 – 22 ], including 2 studies based on cell experiments [ 19 , 20 ] and 2 studies based on animal experiments [ 21 , 22 ]. 12 studies showed the antiarrhythmic effects of NC [ 23 – 34 ], including 9 studies based on cell experiments [ 26 – 34 ] and 3 studies based on animal experiments [ 23 – 25 ].…”

Section: Resultsmentioning

confidence: 99%

“…Three studies reported the antiarrhythmic functions of NC and its active compounds in animal experiments [ 23 – 25 ] (Table 6 ). In the first study, 0.002% aconitine, 1 mL/kg, was used to treat rats in a model group and a Nardosinone group to establish a tachyarrhythmia animal model [ 23 ].…”

Section: Resultsmentioning

confidence: 99%

“…The third experiment presented the validated functions of the volatile oil of NC on the ventricular effective refractory period (ERP) and compared its therapeutic effects between local infiltration and airway inhalation at different time points [ 25 ]. This study showed that the ERP could be remarkably prolonged by the volatile oil of NC and that the best intervention time point was 15–45 min.…”

Section: Resultsmentioning

confidence: 99%

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The cardioprotective and antiarrhythmic effects of Nardostachys chinensis in animal and cell experiments

Xue

Yang

et al. 2017

BMC Complement Altern Med

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BackgroundCardiovascular disease (CVD) is the leading cause of premature death throughout the world. An estimated 17.5 million people died from CVD in 2012, representing 31% of all global deaths. Nardostachys chinensis (NC), a typical traditional Chinese medicine (TCM), plays a crucial role in the management of patients with CVD, especially for those with cardiac arrhythmia. The purpose of this study was to evaluate the cardioprotective and antiarrhythmic effects of NC in animal and cell experiments.MethodsTo review the cardioprotective and antiarrhythmic effects of NC, studies of NC on cardiovascular diseases in animal and cell experiments were identified from five databases through April 2016. Two investigators independently conducted the literature search, study selection, and data extraction.ResultsA total of 16 studies were identified, including five animal experiments and eleven cell experiments. Four studies showed significant effects of NC on myocardial protection by inhibiting myocardial apoptosis, inflammation and oxidative stress. Twelve studies indicated significant beneficial effects of NC in cardiac arrhythmia primarily through the modulation of ion channels (Ik, Ik1, INa, ICa-L, Ito).ConclusionThe above findings showed the possible efficacy of NC via its cardioprotective and antiarrhythmic effects, but the results should be interpreted with caution due to the limitations and the deficiencies in the studies.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

The cardioprotective and antiarrhythmic effects of Nardostachys chinensis in animal and cell experiments

Xue

Yang

et al. 2017

BMC Complement Altern Med

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Nardostachys chinensis Batalin: A review of traditional uses, phytochemistry, and pharmacology

Rehman

Ahmad

2019

Phytotherapy Research

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Nardostachys chinensis Batalin (Valerianaceae) has been widely used in different traditional systems of medicine, including Islamic, Ayurvedic, Chinese, and Korean folk medicine. It has been used in traditional medicine as a tranquilizer, hepatotonic, cardiotonic, diuretic, and analgesic. Preliminary in vitro and in vivo studies have provided valuable scientific evidence for its traditional uses. This review aims to summarize reported traditional uses, phytochemistry, and pharmacological potential of N. chinensis while identifying potential areas of further research of plant. The review comprises literature pertaining to the pharmacological potential and phytochemistry of N. chinensis using worldwide accepted scientific databases via electronic search (Elsevier, Google Scholar, Pub Med, Scopus, Springer, Wiley online library). Moreover, data from ethno botanical text books available in library and electronic search were also included. The Plant List and Kew Herbarium Catalogue databases were used to authenticate the scientific name. Different pharmacological experiments in many in vitro and in vivo models have proved the potential of N. chinensis, namely, antiinflammatory, anticonvulsant, antibacterial, antihypertensive, antifungal, neuroprotective, cardioprotective, aldose reductase inhibition, and antioxidant activities. The plant contains sesquiterpenenes of various varieties including aristolane, guaiane, and nardosinane types. Moreover, it also contains coumarins, phenols, lignans, neolignans, and glycosides. Reported activities suggested that there may be pharmacological potential for developing N. chinensis as a drug for infections, hypertension, cardiac diseases, Alzheimer's disease, insomnia, epilepsy, cancer, gastric, and liver diseases. More toxicological studies should be performed that will aid the progress to clinical trial studies of N. chinensis. Abbreviations: 2K1C, two-kidney one-clip; 5-HT, 5-hydroxytryptamine; ABTS, 2,2′-azino-bis; AChEI, acetylcholinesterase; BChE, butyrylcholinesterase; Bcl-2, B-cell lymphoma 2; CDK, cyclindependent kinase; dbcAMP, dibutyryl cyclic adenosine mono phosphate; Dct, dopachrometautomerase; DPPH, 2,2, diphenyly 1-picryl hydrazyl; EGF, epidermal growth factor; ERK, extracellular signal-regulated kinase; EV, estradiol valerate; FRAP, ferric reducing antioxidant power; GAP-43, growth associated protein 43; ICAM-1, intracellular cell adhesion molecule 1; IP-10, interferon gamma-induced protein 10; I-TAC, interferon-inducible T-cell alpha chemo attractant; IVSd, interventricular septal diameter at end-diastole; IVSs, interventricular septal diameter at end-systole; LDL, low-density lipoprotein; LPS, lipopolysaccharide; LTA, lipoteichoic acid; LVEF, left ventricular ejection fraction; LVFS, left ventricular fractional shortening; LVIDd, left ventricular internal diameter at end-diastole; LVIDs, left ventricular internal diameter at end-systole; LVPWd, left ventricular posterior wall at end-diastole; LVPWs, left ventricular posteriorwall at end-systole; LVW/BW, left vent...

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Wenxin Keli for Ventricular premature complexes with Heart failure: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

Qiu

Tian

et al. 2017

Complementary Therapies in Medicine

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Effects of Nardostachys chinensis on Spontaneous Ventricular Arrhythmias in Rats With Acute Myocardial Infarction

Cited by 12 publications

References 23 publications

The cardioprotective and antiarrhythmic effects of Nardostachys chinensis in animal and cell experiments

The cardioprotective and antiarrhythmic effects of Nardostachys chinensis in animal and cell experiments

Nardostachys chinensis Batalin: A review of traditional uses, phytochemistry, and pharmacology

Wenxin Keli for Ventricular premature complexes with Heart failure: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

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