Curative effect of warming kidney and fortifying spleen recipe on diarrhea-predominant irritable bowel syndrome

Xiaolan, Su; Tang, Yanping; Zhang, Jing; Dong, Yuebin; Wei, Wei; Bai, Yalai; Liu, Yong

doi:10.1016/s0254-6272(14)60030-3

Cited by 15 publications

(20 citation statements)

References 3 publications

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“…Accordingly, the inhibition of inflammatory response is pivotal in the progression of ALI. Clinical observation found that LGS could depress ALI [15]. Here we showed that LGS not only suppressed LPS-stimulated inflammation in vitro , but also inhibited LPS-induced ALI in vivo .…”

Section: Discussionsupporting

confidence: 62%

“…It has been widely used for centuries to clear heat and fire in traditional Chinese medicine. Nowadays, LGS exhibits curative effects on ALI, pharyngitis, amygdalitis and pneumonia [14, 15]. In previous studies, we found that LGS could significantly inhibit the inflammation in LPS-induced ALI rats through suppressing the rise of wet-to-dry ratio of lung tissue and lung permeability.…”

Section: Introductionmentioning

confidence: 94%

See 1 more Smart Citation

Liang-Ge-San, a classic traditional Chinese medicine formula, protects against lipopolysaccharide-induced inflammation through cholinergic anti-inflammatory pathway

Liu

Wei

et al. 2016

Oncotarget

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Liang-Ge-San (LGS) is a classic formula in traditional Chinese medicine, which is widely used to treat acute lung injury (ALI), pharyngitis and amygdalitis in clinic. However, the underlying mechanisms remain poorly defined. In this study, we discovered that LGS exerted potent anti-inflammatory effects in lipopolysaccharide (LPS)-induced inflammation. We found that LGS significantly depressed the production of IL-6 and TNF-α in LPS-stimulated RAW 264.7 macrophage cells. The degradation and phosphorylation of IκBα and the nuclear translocation of NF-κB p65 were also inhibited. Moreover, LGS activated α7 nicotinic cholinergic receptor (α7nAchR). The blockage of α7nAchR by selective inhibitor methyllycaconitine (MLA) or α7nAchR siRNA attenuated the inhibitory effects of LGS on IκBα, NF-κB p65, IL-6 and TNF-α. Critically, LGS significantly inhibited inflammation in LPS-induced ALI rats through the activation of NF-κB signaling pathway. However, these protective effects could be counteracted by the treatment of MLA. Taken together, we first demonstrated anti-inflammatory effects of LGS both in vitro and in vivo through cholinergic anti-inflammatory pathway. The study provides a rationale for the clinical application of LGS as an anti-inflammatory agent and supports the critical role of cholinergic anti-inflammatory pathway in inflammation.

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Section: Discussionsupporting

confidence: 62%

Section: Introductionmentioning

confidence: 94%

Liang-Ge-San, a classic traditional Chinese medicine formula, protects against lipopolysaccharide-induced inflammation through cholinergic anti-inflammatory pathway

Liu

Wei

et al. 2016

Oncotarget

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“…The 15 articles, 12 journal papers, 3 dissertations, and 1 conference proceeding contained 1551 subjects (922 in trail group and 629 in control group). Among them 4 studies were conducted in Australia [ 27 ], Korean [ 39 ], Hong Kong [ 18 ] and Chinese Mainland [ 37 ], respectively, and published in English. The remaining [ 28 – 36 , 38 , 40 ] were all completed in China and published in Chinese.…”

Section: Resultsmentioning

confidence: 99%

“…Ten studies [ 18 , 27 , 28 , 31 , 33 – 35 , 38 – 40 ] used random number tables or lists, 1 study [ 29 , 30 ] used draw by lots, while the remaining 3 did not mention the specific methods. We tried to contact the authors and they confirmed that 2 studies [ 36 , 37 ] used random number tables, but the others [ 32 ] did not respond. All the studies used sealed envelopes except 2 [ 29 , 32 ] which had no details about the blending method and did not respond to our emails.…”

Section: Resultsmentioning

confidence: 99%

“…All the studies used sealed envelopes except 2 [ 29 , 32 ] which had no details about the blending method and did not respond to our emails. 11 trials [ 18 , 27 , 31 , 33 – 40 ] reported drop-out of patients, but Intention-to-Treat (ITT) analyses were not performed in 4 trials [ 27 , 36 – 38 ], in which we just managed to complete it for 1 trial [ 37 ]. Although all trials reported all the outcome measurements mentioned in the methods, we evaluated them as unclear risk due to the inaccessibility of the protocols except 1 trial [ 39 ].…”

Section: Resultsmentioning

confidence: 99%

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Efficacy of Chinese Herbal Medicine for Diarrhea‐Predominant Irritable Bowel Syndrome: A Meta‐Analysis of Randomized, Double‐Blind, Placebo‐Controlled Trials

Zhu

Liu

Xiaolan

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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Objective. To explore the efficacy of Chinese herbal medicine in treating diarrhea-predominant irritable bowel syndrome (D-IBS). Methods. Four English and four Chinese databases were searched through November, 2015. Randomized, double-blind and placebo-controlled trials were selected. Data extraction and quality evaluation were performed by two authors independently. RevMan 5.2.0 software was applied to analyze the data of included trials. Results. A total of 14 trials involving 1551 patients were included. Meta-analysis demonstrated superior global symptom improvement (RR = 1.62; 95% CI 1.31, 2.00; P < 0.00001; number needed to treat = 3.6), abdominal pain improvement (RR = 1.95; 95% CI 1.61, 2.35; P < 0.00001), diarrhea improvement (RR = 1.87; 95% CI 1.60, 2.20; P < 0.00001), pain threshold assessment (MD = 54.53; 95% CI 38.76, 70.30; P < 0.00001), and lower IBS Symptom Severity Score (SMD = −1.01; 95% CI −1.72, −0.30; P = 0.005), when compared with placebo, while for defecation threshold assessment, quality of life, and adverse events, no differences were found between treatment groups and controlled groups. Conclusion. This meta-analysis shows that Chinese herbal medicine is an effective and safe treatment for D-IBS. However, due to the small sample size and high heterogeneity, further studies are required.

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Potential Benefit With Complementary and Alternative Medicine in Irritable Bowel Syndrome: A Systematic Review and Meta-analysis

Billings

Mathur

Craven

et al. 2021

Clinical Gastroenterology and Hepatology

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Background and Aims: Patients with irritable bowel syndrome (IBS) may pursue complementary and alternative medicine (CAM). We conducted a comprehensive systematic review and meta-analysis examining efficacy of CAM vs. placebo or sham in adults with IBS. Methods: Publication databases were searched for randomized controlled trials of CAM therapies (herbal therapy, dietary supplements, mind-body based, body-based, and energyhealing) in adults with IBS. Data were extracted to obtain pooled estimates of mean improvement in abdominal pain (standardized mean difference [SMD]) and relative risk (RR) of overall response using random effects models. Sensitivity and subgroup analyses along with quality assessments were completed. Results: Among 2825 articles identified, 66 were included. Herbal therapy (SMD=0.47, 95% CI: 0.20 to 0.75, I 2 =82%) demonstrated significant benefit over placebo for abdominal pain (low confidence in estimates). Benefit with mind-body based therapy for abdominal pain was of borderline significance (SMD=0.29, 95% CI:-0.01 to 0.59, I 2 =78%). Herbal therapy (RR=1.57, 95% CI: 1.31 to 1.88, I 2 =77%), dietary supplements (RR=1.95, 95% CI: 1.02 to 3.73, I 2 =75%), and mind-body based therapy (RR=1.67, 95% CI: 1.13 to 2.49, I 2 =63%) showed benefit for overall response compared to placebo (low confidence in estimates). Body-based and energy healing therapies demonstrated no significant benefit over placebo or sham for abdominal pain or overall response. Conclusion: CAM therapies such as herbal or dietary supplements and mind-body based approaches may be beneficial for abdominal pain and overall response in IBS. However, overall quality of evidence is low. Rigorous, high quality clinical trials are warranted to investigate CAM in IBS. Billings et al. 3

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Curative effect of warming kidney and fortifying spleen recipe on diarrhea-predominant irritable bowel syndrome

Abstract: Modified Sishen Wan, for warming the kidney and fortifying the spleen, can effectively treat IBS-D and better control its recurrence.

Cited by 15 publications

References 3 publications

Liang-Ge-San, a classic traditional Chinese medicine formula, protects against lipopolysaccharide-induced inflammation through cholinergic anti-inflammatory pathway

Liang-Ge-San, a classic traditional Chinese medicine formula, protects against lipopolysaccharide-induced inflammation through cholinergic anti-inflammatory pathway

Efficacy of Chinese Herbal Medicine for Diarrhea‐Predominant Irritable Bowel Syndrome: A Meta‐Analysis of Randomized, Double‐Blind, Placebo‐Controlled Trials

Potential Benefit With Complementary and Alternative Medicine in Irritable Bowel Syndrome: A Systematic Review and Meta-analysis

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