Clinical Relevance of Plasma miR‐21 in New‐Onset Systemic Lupus Erythematosus Patients

Tang, Zhao Ming; Fang, Min; Wang, Jin Ping; Cai, Peng; Wang, Ping; Li, Hu

doi:10.1002/jcla.21708

Cited by 24 publications

(21 citation statements)

References 29 publications

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“…Further experiments revealed that miR‐21 indirectly downregulated DNMT1 expression by targeting an important autoimmune gene, RASGRP1 . Plasma miR‐21 level in patients with SLE was higher than that of healthy controls and significantly correlated with the level of plasma complement C3, C4 and serum uric acid in patients with SLE .…”

Section: Mirnas In Autoimmune Diseases With Skin Involvementmentioning

confidence: 96%

The Role of MicroRNAs in Autoimmune Diseases with Skin Involvement

Deng

et al. 2015

Scand J Immunol

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MicroRNAs (miRNAs) are small non-coding RNA molecules that negatively modulate gene expression by binding to the 3' untranslated region (UTR) of target messenger RNAs (mRNAs), which leads to the degradation or translational repression of their target mRNAs. Previous research on miRNAs has revealed a new paradigm of gene regulations and pathways involved in the pathogenesis of autoimmune disorders and malignant diseases. The roles of miRNAs in cellular processes, including cell differentiation, proliferation, apoptosis and immune functions, are not clearly understood. MiRNAs are easily detected in a variety of sources, including tissues, serum and other body fluids, and this make them a good biological sample for pathogenic studies and disease biomarker development. This review encompasses the current understanding of the roles of miRNAs in autoimmunity and the cellular and molecular mechanisms of miRNAs in various autoimmune diseases (AIMDs). Specifically, we focus on the target genes of miRNAs and the biological processes associated with autoimmune diseases with skin involvement, including systemic lupus erythematosus, psoriasis, systemic sclerosis, Behcet's disease and dermatomyositis. In addition, the diagnostic and therapeutic relevance of miRNAs that are involved in autoimmunity are elucidated to provide information for clinical implications.

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Section: Mirnas In Autoimmune Diseases With Skin Involvementmentioning

confidence: 96%

The Role of MicroRNAs in Autoimmune Diseases with Skin Involvement

Deng

et al. 2015

Scand J Immunol

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“…moreover, mirs are not located only intracelullarly, but their presence in tissues and body fluids, such as the plasma and the serum [17][18][19][20][21][22][23] , makes them potential blood-based biomarkers of disease development and activity as well as for predicting therapeutic responses. in sle, different patterns of mirs expression have been detected in the plasma [18][19][20][21] , serum 22,23 and urine 22,23 as well as in peripheral mononuclear cells (pBmcs) (ref. [24][25][26][27][28] ).…”

Section: Micrornas and Slementioning

confidence: 99%

MicroRNAs in the key events of systemic lupus erythematosus pathogenesis

Hušáková¹

2016

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Background. Small non-coding RNA molecules (miRs) are involved in immune cell maturation and function and might influence immunopathological processes of systemic lupus erythematosus (SLE) pathogenesis. Methods and Results. This paper presents the results of a literature search for publications dealing with the relationship between miRs and pathological factors related to SLE such as genetic background, immune dysregulation and gender-associated differences participating in SLE development. In SLE, distinct miRs are differentially expressed in SLE cells of innate and adaptive immunity. The miR-146a and miR-155 genes, among others, interfere with intracellular signalling pathways downstream of toll-like receptors 7 and 9 (TLR-7, TLR-9) and influences interferon (IFN)-type I synthesis in plasmacytoid dendritic cells. In T and B cells, miR-126, miR-21, miR-146a, miR-155, miR-1246 and others might influence gene expression by epigenetic modifications, support abnormal cytosine release, differentiation of cell subsets, B cell hyperactivity and autoantibody production. Besides, estrogen might up-and downregulate immunologically active miRs, which are potential mediators of hormonal influences in SLE development. Moreover, SLE genetic basis included some polymorphisms of the miR-146a gene, which varies across populations. Conclusion. Distinct miRs are differentially expressed in both SLE mice models and human patients and promote autoimmune features of immune processes. MiRs are important molecules modulating susceptibility to SLE as well as its onset, clinical diversity and progression.

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“…MiR-21 is detected in higher concentration in plasma from newly diagnosed, treatment-naive lupus patients relative to healthy individuals [6], suggesting that elevated urinary miR-21 may predict a high risk of renal function loss [29]. In lupus mice, miR-21 expression decreases after treatment with hydroxychloroquine, an immunomodulator commonly used for treatment of various SLE manifestations [9].…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, miR-21 is detected in higher concentration in plasma from newly diagnosed, treatment-naive lupus patients compared to healthy individuals [6, 7] and increased concentration of urinary miR-21 may predict a high risk of renal function loss [8]. In lupus prone mice, miR-21 expression in T cells, pDCS, PBMCs and urine is reduced after treatment with hydroxychloroquine [9].…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-21 deficiency protects from lupus-like autoimmunity in the chronic graft-versus-host disease model of systemic lupus erythematosus

Garchow

Kiriakidou

2016

Clinical Immunology

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MicroRNAs (miRNAs) are small, non-coding RNAs that regulate gene expression primarily at the post-transcriptional level. Emerging evidence supports a regulatory role for miRNAs in the immune response and autoimmunity. In this work, we investigated the implication of miR-21 in the experimentally inducible bm12→B6 cGVHD model of systemic lupus erythematosus (SLE). cGVHD host mice deficient in miR-21 show a 2-fold reduction in splenomegaly, significantly reduced autoantibody titers and down-regulated components of the CD40:CD40L and CD28:CD80/86 co-stimulation pathways. Furthermore, we demonstrate that miR-21-deficient hosts have reduced CD4(+) IL-17(+) cell populations and an expanded CD4(+) CD25(+) FoxP3(+) cell compartment. We propose that miR-21 has a pluripotent role, serving to link distinct lymphocyte signaling pathways and acting as a "rheostat" for signals that promote B and T cell activation in lupus. Collectively, our experiments demonstrate that miR-21 deficiency in cGVHD host mice is sufficient to protect from lupus-like autoimmunity.

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Clinical Relevance of Plasma miR‐21 in New‐Onset Systemic Lupus Erythematosus Patients

Abstract: Plasma miR-21 in SLE patients from Central China is overexpressed. Since circulating miR-21 is aberrantly expressed in many diseases, the applying of it as a disease biomarker should be considered carefully.

Cited by 24 publications

References 29 publications

The Role of MicroRNAs in Autoimmune Diseases with Skin Involvement

The Role of MicroRNAs in Autoimmune Diseases with Skin Involvement

MicroRNAs in the key events of systemic lupus erythematosus pathogenesis

MicroRNA-21 deficiency protects from lupus-like autoimmunity in the chronic graft-versus-host disease model of systemic lupus erythematosus

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