Effects of Polyphenol-Rich Chokeberry Juice on Antioxidant/Pro-Oxidant Status in Healthy Subjects

Abstract

Berry fruits are a rich source of polyphenols, especially anthocyanins: well-known potent anti-oxidant phytochemicals. The purpose of this study was to evaluate beneficial effects of long-term consumption of polyphenol-rich organic chokeberry juice on different markers of antioxidant/pro-oxidant status in healthy female volunteers. Twenty-nine women, aged 25-49, were included in the study. Serological markers of oxidative stress and antioxidant defence, blood pressure, routine biochemical, and anthropometric parameters were analyzed at baseline and after twelve weeks of regular chokeberry juice consumption. Significant decrease in thiobarbituric acid-reactive substances level (TBARS; P<.001) and pro-oxidant-antioxidant balance (PAB; P<.05), as well as increase in paroxonase-1 activity toward diazoxon (P<.01) were found. Total oxidative status and sulphydryl groups levels were not significantly influenced by the intervention. Anthropometric, biochemical parameters, and blood pressure values were within the referent values for all subjects and were not influenced by the chokeberry juice consumption. However, we found positive correlation between age, body mass index, waist circumference, body fat percent, blood pressure, and analyzed marker of lipid peroxidation, which was influenced by the consumption. In conclusion, the fine modulation of several antioxidant/pro-oxidant status biomarkers observed in healthy subjects indicates putative prophylactic effects of polyphenol-rich chokeberry juice and supports its importance as part of an optimal diet.

Quantification of Anthocyanins in Elderberry and Chokeberry Dietary Supplements

“…In accordance with this, an improvement of the rheological properties of erythrocytes was shown in hypercholesterolemic patients receiving 300-mg Aronox R over 2 months (Duchnowicz et al, 2012). The exact mechanism of action has not yet been elucidated, but it is agreed that the radical-scavenging effect contributes to the improvement of metabolic syndrome disorders (Keaney et al, 2003;Kardum et al, 2014). A recent study showed that chokeberry also interferes with glucose absorption: in healthy women, postprandial insulin response to wheat was reduced (Törrönen et al, 2013).…”

“…The exact mechanism of action has not yet been elucidated, but it is agreed that the radical‐scavenging effect contributes to the improvement of metabolic syndrome disorders (Keaney et al ., ; Kardum et al ., ). A recent study showed that chokeberry also interferes with glucose absorption: in healthy women, post‐prandial insulin response to wheat was reduced (Törrönen et al ., ).…”

Evaluation of Antioxidant and Anti-Inflammatory Activity of Anthocyanin-Rich Water-Soluble Aronia Dry Extracts

“…In the research carried out by Kardum et al [ 58 ] on the healthy volunteers, it was found that polyphenol-rich aronia juice significantly decreased lipid peroxidation assayed as thiobarbituric acid-reactive substances (TBARS). Other extracts and juices that were rich in anthocyanins (such as bilberry, black currant, and elderberry) also caused a significant reduction in the oxidative stress level in vitro and in vivo [ 59 , 60 , 61 ].…”

Chokeberries (Aronia melanocarpa) and Their Products as a Possible Means for the Prevention and Treatment of Noncommunicable Diseases and Unfavorable Health Effects Due to Exposure to Xenobiotics

“…Kardum and others () have reported that a 3‐mo‐lasting consumption of 100 mL of polyphenol‐rich chokeberry juice 3 times daily by 25 healthy women increased the activities of antioxidative enzymes such as superoxide dismutase (SOD) and glutathione peroxidase (GPx) in the red blood cells, and protected from lipid peroxidation in the membranes of these cells. A 12‐wk‐lasting consumption of chokeberry juice by 29 healthy female volunteers decreased the level of thiobarbituric acid‐reactive substances (TBARS) values, a marker of lipid peroxidation, and it increased the activity of paraoxonase‐1 (an enzyme responsible for antioxidative properties of high‐density lipoproteins) in the plasma (Kardum and others ). The evidence of the antioxidative effectiveness of chokeberries and their products in people suffering from noncommunicable diseases are presented in the latter part of the paper.…”