Phylogenetic Analysis and Seroprevalence of Influenza C Virus in Mie Prefecture, Japan in 2012

Yano, Takuya; Maeda, Chie; Akachi, Shigehiro; Matsuno, Yukari; Yamadera, Motoko; Kobayashi, Takashi; Nagai, Yuhki; Iwade, Yoshito; Kusuhara, Hajime; Katayama, Masahiko; Fukuta, Miwa; Nakagawa, Youji; Naraya, Sagako; Takahashi, Hiroaki; Hiraoka, Masae; Yamauchi, Akinori; Nishinaka, Takamichi; Amano, Hideomi; Yamaguchi, Tetsuo; Ochiai, Hitoshi; Ihara, Toshiaki; Matsuzaki, Yoko

doi:10.7883/yoken.67.127

Cited by 10 publications

(10 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Here we described the isolation of a contemporary ICV—C/Victoria/2/2012 (C/Vic)—from a diseased child with acute respiratory symptoms in 2012. Phylogenetic analysis indicated that viral HEF gene was derived from C/Sao Paulo lineage, which is consistent with the finding that the dominant antigenic group is C/Sao Paulo lineage from 2006 to 2016 . However, its most internal genes (PB1, NP, M, and NS) were donated from multiple ICVs.…”

Section: Introductionsupporting

confidence: 86%

Genetic and antigenic characteristics of a human influenza C virus clinical isolate

Liu

Sheng

Lin

et al. 2019

Journal of Medical Virology

View full text Add to dashboard Cite

Unlike influenza A and B viruses that infect humans and cause severe diseases in seasonal epidemics, influenza C virus (ICV) is a ubiquitous childhood pathogen typically causing mild respiratory symptoms. ICV infections are rarely diagnosed and less research has been performed on it despite the virus being capable of causing severe disease in infants. Here we report on the isolation of a human ICV from a child with acute respiratory disease, provisionally designated C/Victoria/2/2012 (C/Vic). The full‐length genome sequence and phylogenetic analysis revealed that the hemagglutinin‐esterase‐fusion (HEF) gene of C/Vic was derived from C/Sao Paulo lineage, while its PB2 and P3 genes evolved separately from all characterized historical ICV isolates. Furthermore, antigenic analysis using the hemagglutination inhibition (HI) assay found that 1947 C/Taylor virus (C/Taylor lineage) was antigenically more divergent from1966 C/Johannesburg (C/Aichi lineage) than from 2012 C/Vic. Structure modeling of the HEF protein identified two mutations in the 170‐loop of the HEF protein around the receptor‐binding pocket as a possible antigenic determinant responsible for the discrepant HI results. Taken together, results of our studies reveal novel insights into the genetic and antigenic evolution of ICV and provide a framework for further investigation of its molecular determinants of antigenic property and replication.

show abstract

Section: Introductionsupporting

confidence: 86%

Genetic and antigenic characteristics of a human influenza C virus clinical isolate

Liu

Sheng

Lin

et al. 2019

Journal of Medical Virology

View full text Add to dashboard Cite

show abstract

“…In our study, all of the strains isolated in the Philippines and Japan were classified into the SP82-related lineage. In 2012, strains of the SP82-related lineage were also detected in Mie Prefecture, Japan (42). These studies suggest that similar influenza C viruses are circulating worldwide, and viruses classified into the SP82-related lineage may be increasing.…”

Section: Discussionmentioning

confidence: 83%

Isolation and Characterization of Influenza C Viruses in the Philippines and Japan

et al. 2015

Self Cite

View full text Add to dashboard Cite

in the Philippines, 15 influenza C viruses were isolated, using MDCK cells, from specimens obtained from children with severe pneumonia and influenza-like illness (ILI). This is the first report of influenza C virus isolation in the Philippines. In addition, from January 2008 to December 2013, 7 influenza C viruses were isolated from specimens that were obtained from children with acute respiratory illness (ARI) in Sendai city, Japan. Antigenic analysis with monoclonal antibodies to the hemagglutinin-esterase (HE) glycoprotein showed that 19 strains (12 from the Philippines and 7 from Japan) were similar to the influenza C virus reference strain C/Sao Paulo/378/82 (SP82). Phylogenetic analysis of the HE gene showed that the strains from the Philippines and Japan formed distinct clusters within an SP82-related lineage. The clusters that included the Philippine and Japanese strains were shown to have diverged from a common ancestor around 1993. In addition, phylogenetic analysis of the internal genes showed that all strains isolated in the Philippines and Japan had emerged through reassortment events. The composition of the internal genes of the Philippine strains was different from that of the Japanese strains, although all strains were classified into an SP82-related lineage by HE gene sequence analysis. These observations suggest that the influenza C viruses analyzed here had emerged through different reassortment events; however, the time and place at which the reassortment events occurred were not determined.

show abstract

“…The HE protein of influenza C plays a unique role in the influenza C life cycle being responsible for the receptor binding, the receptor destroying enzyme action, and the membrane fusion activities of the virus . A phylogenetic analysis of the HE genes of the Australian influenza C sequences showed that of the six reference groups, the Australian viruses only fell into two of these groups with the majority grouping into the C/Sao Paulo/378/82 clade and a minority of viruses grouping with C/Kanagawa/1/76 clade. Viruses from both Perth and Victoria were found in both of these clades with the viruses from each state often occurring within the same branch and closely grouping according to the year of their collection.…”

Section: Discussionmentioning

confidence: 99%

Influenza C infections in Western Australia and Victoria from 2008 to 2014

Jelley

Levy

Deng

et al. 2016

Influenza Resp Viruses

View full text Add to dashboard Cite

BackgroundInfluenza C is usually considered a minor cause of respiratory illness in humans with many infections being asymptomatic or clinically mild. Large outbreaks can occur periodically resulting in significant morbidity.ObjectivesThis study aimed at analyzing the available influenza C clinical samples from two widely separated states of Australia, collected over a 7‐year period and to compare them with influenza C viruses detected in other parts of the world in recent years.Patients/MethodsBetween 2008 and 2014, 86 respiratory samples that were influenza C positive were collected from subjects with influenza‐like illness living in the states of Victoria and Western Australia. A battery of other respiratory viruses were also tested for in these influenza C‐positive samples. Virus isolation was attempted on all of these clinical samples, and gene sequencing was performed on all influenza C‐positive cultures.Results and conclusionsDetections of influenza C in respiratory samples were sporadic in most years studied, but higher rates of infection occurred in 2012 and 2014. Many of the patients with influenza C had coinfections with other respiratory pathogens. Phylogenetic analysis of the full‐length hemagglutinin–esterase–fusion (HE) gene found that most of the viruses grouped in the C/Sao Paulo/378/82 clade with the remainder grouping in the C/Kanagawa/1/76 clade.

show abstract

Phylogenetic Analysis and Seroprevalence of Influenza C Virus in Mie Prefecture, Japan in 2012

Cited by 10 publications

References 20 publications

Genetic and antigenic characteristics of a human influenza C virus clinical isolate

Genetic and antigenic characteristics of a human influenza C virus clinical isolate

Isolation and Characterization of Influenza C Viruses in the Philippines and Japan

Influenza C infections in Western Australia and Victoria from 2008 to 2014

Contact Info

Product

Resources

About