Probiotics in obese pregnancy do not reduce maternal fasting glucose: a double-blind, placebo-controlled, randomized trial (Probiotics in Pregnancy Study)

Abstract

Probiotic treatment of 4 wk during pregnancy did not influence maternal fasting glucose, the metabolic profile, or pregnancy outcomes in obese women.

Probiotic Foods and Supplements Interventions for Metabolic Syndromes: A Systematic Review and Meta-Analysis of Recent Clinical Trials

“…An abnormal fasting insulin level indicates a potential risk of developing diabetes; thus, it is crucial for both patients and health-care professionals to take precautionary measures to prevent diabetes when abnormal fasting insulin levels are presented [67]. In the 6 reviewed studies, the authors did not find significant fasting insulin differences between the intervention groups and control groups [38,43,47,50,57,66]. Except for the study without original data conducted by Chung et al [47].…”

“…The reasons for the removal include lack of original data [47], data without specific SD of fasting glucose [48], and outcome indicator being serum glucose, not fasting glucose [42]. Among the remaining 7 studies, 5 of them found no significant differences in fasting glucose or blood glucose in between-group comparisons [38,43,50,55,57]. In the 2014 4-arm study by Ivey et al [66], the researchers used a 4-arm approach: (A) probiotic yogurt plus probiotic capsules, (B) probiotic yogurt plus placebo capsules, (C) control milk plus probiotic capsules, and (D) control milk plus placebo capsules.…”

“…Based on the criteria from the Centre for Evidence-Based Medicine [41], these individual RCTs (with narrow CI) had a 1B level of evidence. In the 18 reviewed RCTs, the durations of Sharafedtinov et al [42] (3 weeks) and Lindsay et al [43] (4 weeks) were below Cochrane recommended duration (6 weeks, Section 8.6, Fig. 8.6.a), which may lead to short-term outcome and attrition bias [33].…”

Multiple effects of probiotics on different types of diabetes: a systematic review and meta-analysis of randomized, placebo-controlled trials

“…However, their dosages, bacterial strains and time of therapy were short of homogeneity. In addition, some of the studies have not shown a positive curative effect and their conclusions still remain controversial, for some studies gave negative results [12,22]. Previous systematic reviews and meta-analyses have shown that probiotics had an effect on diabetes, but their pooled results showed a lack of accordance and their included studies were uncomprehensive, which could lead to a possibility of unreliable results and conclusions [27][28][29].…”

“…Several clinical trials have shown the effect of probiotics on the reduction of glucose, insulin, HbA 1c and other glycemic factors for type 2 diabetes mellitus (T2DM) [10][11][12][13][14][15][16][17][18][19] and other diabetes or metabolic syndrome (defined as MS) [9,[20][21][22][23][24][25][26]. However, their dosages, bacterial strains and time of therapy were short of homogeneity.…”