Association of physical activity with glycaemic control and cardiovascular risk profile in 65 666 people with Type 2 diabetes from Germany and Austria

Hermann, Gerhard; Herbst, Antje; Schütt, M.; Kempe, Hans‐Peter; Krakow, D; Müller-Korbsch, Michael; Holl, Reinhard W.

doi:10.1111/dme.12438

Cited by 19 publications

(11 citation statements)

References 30 publications

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“…Studies indicate that in patients with type 2 diabetes the CVD risk profile can be improved through regular PA (7)(8)(9). Furthermore, meta-analyses show an HbA 1c -lowering effect in patients with type 2 diabetes who engage in regular PA (8,10).…”

mentioning

confidence: 99%

Impact of Physical Activity on Glycemic Control and Prevalence of Cardiovascular Risk Factors in Adults With Type 1 Diabetes: A Cross-sectional Multicenter Study of 18,028 Patients

Bohn

Herbst

Pfeifer³

et al. 2015

Diabetes Care

267

178

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OBJECTIVEPhysical activity (PA) can improve cardiovascular risk in the general population and in patients with type 2 diabetes. Studies also indicate an HbA 1c -lowering effect in patients with type 2 diabetes. Since reports in patients with type 1 diabetes are scarce, this analysis aimed to investigate whether there is an association between PA and glycemic control or cardiovascular risk in subjects with type 1 diabetes. RESEARCH DESIGN AND METHODSA total of 18,028 adults ( ‡18 to <80 years of age) from Germany and Austria with type 1 diabetes from the Diabetes-Patienten-Verlaufsdokumentation (DPV) database were included. Patients were stratified according to their self-reported frequency of PA (PA0, inactive; PA1, one to two times per week; PA2, more than two times per week). Multivariable regression models were applied for glycemic control, diabetes-related comorbidities, and cardiovascular risk factors. Data were adjusted for sex, age, and diabetes duration. P values for trend were given. SAS 9.4 was used for statistical analysis. RESULTSAn inverse association between PA and HbA 1c , diabetic ketoacidosis, BMI, dyslipidemia (all P < 0.0001), and hypertension (P = 0.0150), as well as between PA and retinopathy or microalbuminuria (both P < 0.0001), was present. Severe hypoglycemia (assistance required) did not differ in PA groups (P = 0.8989), whereas severe hypoglycemia with coma was inversely associated with PA (P < 0.0001). CONCLUSIONSPA seemed to be beneficial with respect to glycemic control, diabetes-related comorbidities, and cardiovascular risk factors without an increase of adverse events. Hence, our data underscore the recommendation for subjects with type 1 diabetes to perform regular PA.

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mentioning

confidence: 99%

Impact of Physical Activity on Glycemic Control and Prevalence of Cardiovascular Risk Factors in Adults With Type 1 Diabetes: A Cross-sectional Multicenter Study of 18,028 Patients

Bohn

Herbst

Pfeifer³

et al. 2015

Diabetes Care

267

178

View full text Add to dashboard Cite

show abstract

“…T2D patients with comorbid psoriasis should be further encouraged to improve their metabolic status in order to lower the risk for complications. Lifestyle changes such as physical activity showed a positive influence on metabolic control, diabetes treatment, BMI, and cardiovascular risk profile in T2D patients [ 54 ]. Moreover, previous research indicated that physical activity is an effective treatment in psoriasis [ 55 ].…”

Section: Discussionmentioning

confidence: 99%

Psoriasis and Diabetes: A Multicenter Study in 222078 Type 2 Diabetes Patients Reveals High Levels of Depression

Schwandt

Bergis

Dapp³

et al. 2015

Journal of Diabetes Research

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Objective. This study aimed to investigate the association between psoriasis and disease outcome in type 2 diabetes (T2D). Methods. 222078 T2D patients (≥10 years old) from the prospective, multicenter diabetes patient registry were analyzed. Specific search items were used to identify psoriasis patients. Multiple regression models were fitted and adjusted for demographic confounder. Results. 232 T2D patients had comorbid psoriasis. After adjusting psoriasis patients revealed a higher BMI (31.8 [31.0; 32.6] versus 30.6 [30.5; 30.6] kg/m2, p = 0.004) and HbA1c (64.8 [62.1; 67.6] versus 59.0 [58.9; 59.1] mmol/mol, p < 0.0001). Insulin was used more frequently (62.3 [55.7; 68.5] versus 50.9 [50.7; 51.1] %, p = 0.001), only OAD/GLP-1 was similar, and nonpharmacological treatment was less common (13.3 [9.5; 18.3] versus 21.9 [21.7; 22.1] %, p = 0.002). Severe hypoglycemia (0.31 [0.238; 0.399] versus 0.06 [0.057; 0.060] events per patient-year, p < 0.0001), hypertension (86.1 [81.1; 90.0] versus 68.0 [67.8; 68.2] %, p < 0.0001), and thyroid disease (14.0 [10.1; 19.2] versus 4.6 [4.5; 4.7] %, p < 0.0001) were more prevalent. Depression occurred more often (10.5 [7.1; 15.2] versus 2.8 [2.7; 2.8] %, p < 0.0001). Conclusions. Clinical diabetes characteristics in psoriasis T2D patients were clearly worse compared to patients without psoriasis. Comorbid conditions and depression were more prevalent, and more intensive diabetes therapy was required.

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“…The current therapy of gestational hypertension include antispasmodic, antihypertensive, sedative and termination of pregnancy, all of them are symptomatic treatments after the onset, without safe and effective precaution (Abalos 2001;Amaral et al 2017). The benefits of physical activity on health, such as reducing the risk of essential hypertension, coronary atherosclerotic heart disease, and type 2 diabetes are well documented, but there is a gap between physical activity and the risk of gestational hypertension (Coenen 2018;Hermann et al 2014). If it proves to be effective, maybe physical activity can be used as an adjunct and preventive intervention for gestational hypertension.…”

Section: Introductionmentioning

confidence: 99%

Impact of Physical Activity During Pregnancy on Gestational Hypertension

Gao

Ren

Zhou

et al. 2020

Physical Activity and Health

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Background: Hypertensive disorders of pregnancy are characterised by new onset of hypertension after 20 weeks gestation, proteinuria and other associated complications, which are major causes of adverse maternal and neonatal outcome. The benefits of physical activity on reducing the risk of essential hypertension, coronary atherosclerotic heart disease and type 2 diabetes are well documented, but the effcet of physical activity on gestational hypertension is inconclusive. This review presents the state of knowledge related to the impact of physical activity on gestational hypertension. Methods: We searched physical activity and gestational hypertension studies and highlight key articles with a focus on maternal health outcomes to best inform physical activity promotion efforts. Results: Physical activity during pregnancy can reduce the risk of gestational hypertension by improving placental blood flow perfusion deficiency, reducing oxidative stress, improving insulin resistance and improve the prognosis of maternal and fetus. Conclusion: Physical activity is of great benefit to improve the occurrence and development of gestational hypertension. Pregnant women should be guided according to individual factors and complications during pregnancy. However, there have no gold standard about physical activity norms based on gestational hypertension. Scientific computation of big data in real-world clinical research are needed in future research.

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Association of physical activity with glycaemic control and cardiovascular risk profile in 65 666 people with Type 2 diabetes from Germany and Austria

Cited by 19 publications

References 30 publications

Impact of Physical Activity on Glycemic Control and Prevalence of Cardiovascular Risk Factors in Adults With Type 1 Diabetes: A Cross-sectional Multicenter Study of 18,028 Patients

Impact of Physical Activity on Glycemic Control and Prevalence of Cardiovascular Risk Factors in Adults With Type 1 Diabetes: A Cross-sectional Multicenter Study of 18,028 Patients

Psoriasis and Diabetes: A Multicenter Study in 222078 Type 2 Diabetes Patients Reveals High Levels of Depression

Impact of Physical Activity During Pregnancy on Gestational Hypertension

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