Extrapituitary growth hormone in the chicken reproductive system

Luna, Maricela; Martínez-Moreno, Carlos G.; Ahumada-Solórzano, Marisela S.; Harvey, S.; Carranza, Martha; Arámburo, Carlos

doi:10.1016/j.ygcen.2014.02.021

Cited by 27 publications

(15 citation statements)

References 84 publications

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“…Most recent investigation showed that the chicken oviduct, like the ovary, is an extrapituitary site of GH production and a target organ for this hormone (Hrabia et al, 2013(Hrabia et al, , 2014bLuna et al, 2014). The avian oviduct is a unique organ divided morphologically and functionally into five parts.…”

Section: Participation Of Growth Hormone In Oviduct Functionmentioning

confidence: 99%

“…Growing evidence demonstrates that growth hormone (GH) is produced not only by pituitary gland but also by numerous extrapituitary tissues including neural , immunological (Luna et al, 2008(Luna et al, , 2013 and reproductive ones (Harvey, 2010;Luna et al, 2014;Sirotkin, 2005) in which it can act through paracrine and/or autocrine pathways. In this brief review, based on available literature and the author's own studies, up-to-date discoveries concerning the expression of GH and its receptors in the female reproductive system, mainly of chickens are presented.…”

Section: Introductionmentioning

confidence: 99%

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Growth hormone production and role in the reproductive system of female chicken

Hrabia

2015

General and Comparative Endocrinology

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Section: Participation Of Growth Hormone In Oviduct Functionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Growth hormone production and role in the reproductive system of female chicken

Hrabia

2015

General and Comparative Endocrinology

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“…It is also important to reflect that the GH variant GHV, seems to be the most abundant GH mRNA isoform in the human testis [152], while in chicken the GH 17 kDa variant is predominant [153].…”

Section: Ghd and Testicular Functioningmentioning

confidence: 99%

Growth Hormone Deficiency: Is It Just a Problem of Growth Impairment? Part I

Devesa¹

2020

Growth Disorders and Acromegaly

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The concept that the growth hormone (GH) is a merely metabolic pituitary hormone with effects on the longitudinal growth of the organism until the end of puberty has been questioned in recent years. We know today that the expression of GH also occurs in virtually all organs and tissues where it performs very important autocrine/paracrine and even intracrine functions. GH acts on all organs and tissues, being particularly important in the development of the brain during the fetal period. In addition, the hormone, after interacting with its membrane receptor, is internalized together with its receptor, allowing it to reach the cell nucleus where it acts as a transcription factor. In the first part of this review, we will analyze the effects of GH on the brain, the cardiovascular system, and the gonadal system, as well as the adverse effects that occur in the GH deficiency not treated in children and adults. GH is absolutely necessary for a normal brain development and also for repairing the nervous system after an injury. Moreover, GH plays a very important role in the cardiovascular system, as well as in normal gonadal functioning.

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“…Concentrations of testosterone (T), estradiol (E), arginine-vasotocin (AVT) and growth hormone (GH) were determined in 25 µl aliquots of plasma or incubation medium by EIA and RIA, whose were previously validated for use in culture medium Grossmann 2007). These hormones were considered as the indices of ovarian secretory activity, stress, response to hormonal stimuli and the key regulators of both mammalian (Sirotkin 2014) and chicken , 2008, Luna et al 2014, Sirotkin 2014, Hrabia 2015) ovarian functions.…”

Section: Immunoassaymentioning

confidence: 99%

“…The general aim of the present study was to examine the role of the nutritional status, metabolic hormone ghrelin and their interrelationships in the control of chicken steroid and peptide hormones involved in the regulation of reproduction. For this purpose, we used both in-vivo and in-vitro approaches to identify the effect of food deprivation, administration of ghrelin 1-18 and their combination on plasma level of hormones (T, E, AVT and growth hormone, GH) whose are known autocrine/paracrine and endocrine regulators of both mammalian and avian ovarian functions (Sirotkin 2005, 2014, Luna et al 2014, Hrabia 2015 as well as the release of these hormones by isolated and cultured ovarian fragments.…”

Section: Introductionmentioning

confidence: 99%

Metabolic Status and Ghrelin Regulate Plasma Levels and Release of Ovarian Hormones in Layer Chicks

Sirotkin

Harrath²,

Großmann³

2017

Physiol Res

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The aim of the present study was to examine the role of nutritional status, the metabolic hormone ghrelin and their interrelationships in the control of chicken hormones involved in the regulation of reproduction. For this purpose, we identified the effect of food deprivation, administration of ghrelin 1-18 and their combination on plasma levels of testosterone (T), estradiol (E), arginine-vasotocin (AVT) and growth hormone (GH) as well as the release of these hormones by isolated and cultured ovarian fragments. It was observed that food deprivation reduces plasma T and E and increases plasma AVT and GH levels. Food restriction also reduced the amount of E produced by isolated ovaries, but it did not affect the ovarian secretion of T and AVT. No ovarian GH secretion was detected. Ghrelin administered to ad libitum fed chickens did not affect plasma T and E levels, but it did increase plasma GH and AVT concentrations. Moreover, it partially prevented the effect of food deprivation on plasma E and AVT levels, but not on T or GH levels. Ghrelin administration to control birds promoted ovarian T, but not E or AVT release and reduced T and no other hormonal outputs in birds subjected to food restriction. Our results (1) confirmed the ovarian origin of the main plasma T and E and the extra-ovarian origin of the main blood AVT and GH; (2) showed that food deprivation-induced suppression of reproduction may be caused by suppression of T and E and the promotion of AVT and GH release; (3) suggest the involvement of ghrelin in control chicken E, AVT and GH output; and (4) indicates that ghrelin can either mimic or modify the effect of the intake of low calories on chicken plasma and ovarian hormones, i.e. it can mediate the effect of metabolic state on hormones involved in the control of reproduction.

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Extrapituitary growth hormone in the chicken reproductive system

Cited by 27 publications

References 84 publications

Growth hormone production and role in the reproductive system of female chicken

Growth hormone production and role in the reproductive system of female chicken

Growth Hormone Deficiency: Is It Just a Problem of Growth Impairment? Part I

Metabolic Status and Ghrelin Regulate Plasma Levels and Release of Ovarian Hormones in Layer Chicks

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