Diclofenac-induced pseudoporphyria; an under-recognized condition?

Turnbull, Nicholas; Callan, Margaret; Staughton, R.C.D.

doi:10.1111/ced.12313

Cited by 9 publications

(1 citation statement)

References 6 publications

(5 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The chronic toxicity investigated for 9 repeated doses of higher concentration (6.4 x 10 -6 and 100 x 10 -6 mol/L) was also tested. The toxic effects were observed starting from a very small clinically relevant concentration (6.4 x 10 -6 mol/L), that generates negative influences on exometabolome, induces apoptosis in hepatocytes [17] and might induce pseudoporphyria [50]. The toxicity assay is also requested for veterinary treatments and for environmental pollution of water.…”

Section: Introductionmentioning

confidence: 99%

COMPARATIVE DICLOFENAC DETECTION FOR CHRONIC TOXICITY LEVELS USING WATER SOLUBLE Zn-METALLOPORPHYRIN, GOLD NANOPARTICLES AND THEIR HYBRID

Palade¹

2018

FARMACIA

View full text Add to dashboard Cite

The optical detection of chronic toxicity levels of diclofenac were comparatively investigated using novel nanostructured materials, such as: a water soluble metalloporphyrin: Zn(II)-tetra-(4-N-methyl-4-pyridyl)porphyrin tetrachloride (ZnTMePyP), tailored size spherical gold nanoparticles (n-Au) of 15 -20 nm, and the hybrid nanomaterial (ZnTMePyP/n-Au) formed between them. After spectroscopic and microscopic analyses, it can be stated that the water soluble Zn-porphyrin alone can detect diclofenac in a larger domain of concentration (2.57 x 10 -5 -14.15 x 10 -5 mol/L) than the hybrid formed between the metalloporphyrin and n-Au and that the gold nanoparticles alone are not capable of diclofenac detection. RezumatA fost investigată capacitatea unor noi materiale nanostructurate de a detecta prin spectroscopie UV-Vis concentrații de diclofenac din domeniul relevant toxicității cronice, utilizând o metaloporfirină solubilă în apă, și anume: tetraclorura de Zn(II)-tetra-(4-N-metil-4-piridil)porfirina (ZnTMePyP), nanoparticule sferice de aur (n-Au) cu dimensiune controlată (15 -20 nm în diametru) precum și materialul hibrid format între ele (ZnTMePyP/n-Au). În urma analizelor spectroscopice și microscopice efectuate s-a constatat că Zn-porfirina folosită singură poate detecta un domeniu mai larg de concentrații de diclofenac (2.57 x 10 -5 -14.15 x 10 -5 mol/L) decât hibridul format intre ea și n-Au, precum și că nanoparticulele de aur nu au capacitate de detecție pentru diclofenac.

show abstract

Section: Introductionmentioning

confidence: 99%