A comparison of bolus injection of landiolol versus oral administration of propranolol before cardiac computed tomography

Nakamura, Yoshitaka; Yamaji, Kyohei; Saho, Tatsunori; Matsuzaki, Zyousin; Yuda, Itsuo; Soga, Yoshimitsu; Shirai, Shinichi; Ando, Kenji; Nobuyoshi, Masakiyo

doi:10.1186/2193-1801-3-93

Cited by 3 publications

(5 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…66 However, bradycardia was not reported in other studies that used landiolol injection of 0.125-0.5 mg/kg. 7,18,65,67 When continuous injection between 3 and 5 µg/kg/min was used to control the heart rate after cardiac surgery, ten of 68 patients experienced bradycardia (heart rate ,50 bpm), which recovered after cessation of drug infusion and administration of a cardiotonic agent.…”

Section: Bradycardiamentioning

confidence: 51%

“…7,18,65,67 When continuous injection between 3 and 5 µg/kg/min was used to control the heart rate after cardiac surgery, ten of 68 patients experienced bradycardia (heart rate ,50 bpm), which recovered after cessation of drug infusion and administration of a cardiotonic agent. 15 Hypotension Hypotension is a rare side effect when a bolus injection of 0.125 mg/kg landiolol is used, 7,18,67 although Nakamura et al 66 reported hypotension (86/55 mmHg) in one out of 188 patients, which recovered after 10 minutes. Another study reported that one of 28 patients who received 0.25 mg/kg landiolol had mild hypotension, which resolved without any treatment.…”

Section: Bradycardiamentioning

confidence: 99%

“…7 Another study that assessed the difference in the reduction of heart rate between landiolol and propranolol showed that a bolus dose of 0.125 mg/kg of landiolol decreased the heart rate by 8.8 bpm, which was slightly inferior to 10-20 mg of oral propranolol that reduced the heart rate by 11 bpm. 66 Hirano et al 67 assessed the reductive effects of different doses of landiolol on heart rate during coronary CT angiography. Compared with a bolus injection of 0.125 mg/kg, increased doses of 0.25 mg/kg and 0.50 mg/kg resulted in greater reduction of heart rate than that by 0.125 mg/kg injection ( Table 1).…”

Section: Effects Of Landiolol On Heart Rate During Coronary Ct Angiogmentioning

confidence: 99%

“…High-dose landiolol reduced segments with a nondiagnostic image quality from 42% to 22% when the initial heart rate was higher than 75 bpm. 66 Another study compared the image quality in coronary CT angiography between patients with a bolus injection of 0.125, 0.25, and 0.5 mg/kg landiolol by using a 32-row scanner. 67 Although the reduction in heart rate was highest in the 0.5 mg/kg group, the image quality did not significantly differ.…”

Section: Tomizawa Et Almentioning

confidence: 99%

See 3 more Smart Citations

Clinical utility of landiolol for use in coronary CT angiography

Tomizawa¹,

Hayakawa²,

Inoh³

et al. 2015

RRCC

View full text Add to dashboard Cite

Although remarkable advancement in computed tomography (CT) has been achieved, heart rate control is important to maintain an optimal image quality in coronary CT angiography. Oral or intravenous β-blockers are used as premedication for this purpose. Landiolol was developed as a β-blocker with very high cardioselectivity (β1/β2 =255) and short half-life (4 minutes). In this review, we report the pharmacological features and usage of landiolol and also its effects on heart rate and image quality in coronary CT angiography. In addition, we discuss the safety of landiolol.

show abstract

Section: Bradycardiamentioning

confidence: 51%

Section: Bradycardiamentioning

confidence: 99%

Section: Effects Of Landiolol On Heart Rate During Coronary Ct Angiogmentioning

confidence: 99%

Section: Tomizawa Et Almentioning

confidence: 99%

See 2 more Smart Citations

Clinical utility of landiolol for use in coronary CT angiography

Tomizawa¹,

Hayakawa²,

Inoh³

et al. 2015

RRCC

View full text Add to dashboard Cite

show abstract

“…If the HR remained > 60 beats/minute prior to the scan, 0.125 mg/kg of an ultrashort acting intravenous β-blocker (landiolol, Ono Pharmaceutical Co., LTD., Osaka, Japan) was administered to further reduce the HR. 20) Immediately before image acquisition, almost all patients received 0.3 mg nitroglycerin sublingual. Scan parameters were as follows: a collimation of 320 rows × 0.5 mm, rotation time of 350-400 ms, and tube voltage of 120 kV.…”

Section: Methodsmentioning

confidence: 99%

Association of Dyslipidemia and Sex With Coronary Artery Calcium Assessed by Coronary Computed Tomography Angiography

et al. 2017

Self Cite

View full text Add to dashboard Cite

SummaryPrevious studies reporting that statin increases coronary artery calcium (CAC) were conducted exclusively on patients with statin as a prevention, regardless of the presence or absence of dyslipidemia. The impact of sex on CAC has not been fully evaluated. We aimed to determine the association of dyslipidemia and sex with CAC using 320-row multi-detector computed tomography (MDCT).Of the 356 consecutive patients who underwent coronary MDCT, 251 patients were enrolled, after excluding those with prior stenting and/or coronary bypass grafting or images showing motion artifacts. The primary outcome measures were the percent calcium volume (PCV) and percent atheroma volume (PAV) per coronary vessel.Multivariable analyses indicated that PCV was significantly higher in dyslipidemia patients without statins than in the subjects without dyslipidemia [partial regression coefficient (PRC): 2.59, 95% confidence interval (CI): 0.83 to 4.34, P = 0.004]. In contrast, PCV was similar in dyslipidemia patients taking statins and those without dyslipidemia (PRC: -1.09, 95% CI: -2.82 to 0.65, P = 0.22). There was no significant difference in PCV between men and women, although women exhibited a significantly lower PAV (PRC: -2.87, 95% CI: -4.54 to -1.20, P = 0.001).In low-risk patients, these results could be translated into hypotheses, which should be tested in future prospective studies. Furthermore, there was no significant difference in CAC between men and women, but women had lower PAV than men.(Int Heart J 2017; 58: 695-703) Key words: Coronary plaque burden, Low-risk, Statin, Multi-detector computed tomography, Sex difference T he presence of calcified plaques in the coronary artery is associated with future adverse coronary events.1-3) Statin therapy was proven efficient for the primary and secondary preventions of coronary adverse events 4,5) through stabilization of unstable plaques and management of low-density lipoprotein (LDL) cholesterol levels.6,7) However, it remains to be elucidated whether there is any association between statin and coronary artery calcium (CAC) formation. 8) Recent intravascular ultrasound (IVUS) studies indicated that high-dose statin therapy leads to a reduction in the necrotic core volume, but to an increase in tissue calcification.9-12) These IVUS studies were conducted on high-risk patients diagnosed with coronary artery disease (CAD) [9][10][11] or STsegment elevation myocardial infarction (STEMI).12) As those patients received statin therapy regardless of the presence or absence of dyslipidemia, we could not differentiate the effect of statins and dyslipidemia on CAC. Furthermore, the region of interest in IVUS was limited to the proximal coronary vessels, instead of the entire coronary vasculature.Multi-detector computed tomography (MDCT) provides images of all coronary arteries with a higher specificity of CAC. The efficiency of MDCT remains controversial as some studies reported a significant impact of statin therapy on coronary plaque burden and/or CAC, 13,14) whereas others re...

show abstract

Impact of Indoxyl Sulfate on Coronary Plaques in Patients on Hemodialysis

et al. 2018

View full text Add to dashboard Cite

Serum indoxyl sulfate (IS; a uremic toxin) levels, which are significantly higher in patients with chronic kidney disease, including those undergoing hemodialysis, than in the robust, are associated with both cardiovascular disease (CVD) and CVD-related mortality. Furthermore, coronary artery calcium (CAC) is an independent predictor of cardiovascular events in patients undergoing hemodialysis. This study aimed to interpret the association between serum IS levels and coronary plaque burden (CPB) or CAC.A total of 30 consecutive patients on hemodialysis, who underwent 320-row coronary multidetector computed tomography (MDCT) angiography for suspected coronary artery disease, were enrolled in this prospective study. Coronary artery percent atheroma volume (a CPB marker) and percent calcium volume (a CAC marker) assessed using MDCT were evaluated. Furthermore, various oxidative and inflammatory markers typified by serum IS levels at a dialysis-free day were measured. Using these data, we investigated correlation between the inflammatory marker IS and CPB or CAC.Multivariable analysis indicated that serum IS levels were positively correlated with CAC [partial regression coefficient, 2.89; 95% confidence interval (CI), 0.35-5.43; P = 0.03] but not with CPB, even after adjustment for cofounders. Composite cardiovascular events, namely, as all-cause death, non-fatal myocardial infarction, disabling stroke, and hospital admission for other cardiovascular events, were reported to be 50% in all patients (95% CI, 32.1-67.9).In patients undergoing hemodialysis, serum IS levels were significantly associated with CAC but not with CPB.

show abstract

A comparison of bolus injection of landiolol versus oral administration of propranolol before cardiac computed tomography

Cited by 3 publications

References 22 publications

Clinical utility of landiolol for use in coronary CT angiography

Clinical utility of landiolol for use in coronary CT angiography

Association of Dyslipidemia and Sex With Coronary Artery Calcium Assessed by Coronary Computed Tomography Angiography

Impact of Indoxyl Sulfate on Coronary Plaques in Patients on Hemodialysis

Contact Info

Product

Resources

About