The Modulatory Role of Spinally Located Histamine Receptors in the Regulation of the Blood Glucose Level in D-Glucose-Fed Mice

Sim, Yun-Beom; Park, Soo-Hyun; Kim, Sung‐Su; Kim, Chea-Ha; Kim, Sujin; Lim, Seungyup; Jung, Jun‐Sub; Ryu, Ohk Hyun; Choi, Moon-Gi; Suh, Hwal

doi:10.4196/kjpp.2014.18.1.41

Cited by 6 publications

(8 citation statements)

References 22 publications

(21 reference statements)

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“…In our previous study, we already demonstrated the role of spinally located histamine receptor in regulation of the blood glucose level in D-glucose fed mice model (Sim et al 2014). In the present study, we found that i.t.…”

Section: Discussionsupporting

confidence: 71%

“…In our previous study, we reported that the spinally located histamine H2 receptor activation and histamine receptors H1 or H3 blockade play a modulatory role in blood glucose regulation in D-glucose fed mice model (Sim et al 2014). In the present study, we found that the elevation of the blood glucose level induced by IMO was attenuated by i.c.v.…”

Section: Discussionsupporting

confidence: 57%

“…Doses of histamine agonist and antagonist were selected according to our previous study (Sim et al 2014). Mice were pretreated i.c.v.…”

Section: Effects Of Histamine Receptor Agonists or Antagonists Adminimentioning

confidence: 99%

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Effect of histamine receptors agonists or antagonists administered intracerebroventricularly and intrathecally on the blood glucose level in immobilization stress model

Sharma

Sim

Park

et al. 2015

Animal Cells and Systems

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Effects of histamine receptors agonists or antagonists administered centrally (supraspinally or spinally) on immobilization stress-induced blood glucose levels were studied in Institute for Cancer Research mice. Mice were pretreated intracerebroventricularly (i.c.v.) or intrathecally (i.t.) with histamine (H1, H2, H3 and H4) receptor agonists or antagonists 10 min prior to immobilization stress (IMO) stimulation for 30 min. We found that the increased blood glucose level induced by IMO was attenuated by the i.c.v. pretreatment with α-methylhistamine (H3 agonist). However, H3 antagonist, H1, H2 and H4 receptor agonists and antagonists did not affect the blood glucose level. Also, i.t. pretreatment with α-methylhistamine or VUF 8430 attenuated the increased blood glucose level induced by IMO. In addition, cetirizine and carcinine enhanced the increased blood glucose level induced by IMO. However, the blood glucose level was not affected by H1 and H2 receptor agonists, H2 and H4 receptor antagonists. Corticosterone and insulin levels were also measured in α-methylhistamine (i.c.v or i.t) and with VUF 8430, carcinine and cetirizine (i.t.) treated group. We found that the corticosterone level was increased only by i.t treatment with α-methylhistamine, whereas the insulin level was attenuated by i.c.v or i.t. treatment with α-methylhistamine and i.t treatment with VUF 8430, carcinine and cetirizine. Our results suggest the active involvement of histamine receptor in blood glucose regulation in IMO.

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Section: Discussionsupporting

confidence: 71%

Section: Discussionsupporting

confidence: 57%

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Effect of histamine receptors agonists or antagonists administered intracerebroventricularly and intrathecally on the blood glucose level in immobilization stress model

Sharma

Sim

Park

et al. 2015

Animal Cells and Systems

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“…The blood glucose level is regulated not only by insulin but also by the histamine system [37,38]. Our study showed a decrease in the plasma histamine level of chickens receiving Cr at 3 mg/kg, irrespective of the form used.…”

Section: Discussionmentioning

confidence: 52%

“…It is likely that Cr, by increasing the plasma insulin level, causes a decrease in the concentration of histidine, which is a precursor of histamine. In addition to the direct involvement of histamine receptors in the regulation of blood glucose, several studies have shown that the activation or deactivation of histamine receptors appears to have a modulating role in the regulation of the blood glucose level [38].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Chromium Nanoparticles and Chromium Picolinate in the Diet of Chickens on Levels of Selected Hormones and Tissue Antioxidant Status

Stępniowska

Drażbo

Kozłowski

et al. 2019

Animals

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Simple Summary:We have postulated that supplementation with Cr can increase serotonin levels and improve the antioxidant status of chickens, with no adverse effect on the secretion of other hormones. Obtaining such results may be beneficial in high-density rearing of poultry exposed to many stressors. The studies compared the effects of two forms of Cr (Cr-Pic and Cr-NP) found at two doses 3 and 6 mg/kg. It was found that at the dose of 3 mg/kg, the expected beneficial results can be obtained (increase in serotonin and decrease in norepinephrine level), however, due to the deterioration of the antioxidative system, these studies should be continued to verify these results. Due to the adverse effect of Cr at 3 mg/kg on the antioxidant status of chickens, this level of Cr should not be considered in both forms Cr-Pic and Cr-NP as a feed additive for broiler chickens. In the future, studies on the potential beneficial effects of Cr on the organism should take into account doses lower than 3 mg/kg. Abstract:We have postulated that supplementation with Cr can increase serotonin levels and improve the antioxidant status of chickens, with no adverse effect on the secretion of other hormones. The study aimed to determine what form and dose of Cr more favorably affect the level of selected hormones (insulin, glucagon, serotonin, dopamine, noradrenaline, histamine, T3 and T4) and the antioxidant status (level of malondialdehyde and lipid peroxides, activity of superoxide dismutase and catalase) of chicken tissues. The experiment was carried out on chickens randomly divided into five treatment groups. The basal diets (control group) were supplemented with two levels of Cr (3 and 6 mg/kg) and two Cr sources: Cr-picolinate (Cr-Pic) and Cr-nano (Cr-NP) to obtain four experimental diets: 3 mg/kg Cr-Pic, 6.0 mg/kg Cr-Pic, 3.0 mg/kg Cr-NP. and 6.0 mg/kg Cr-NP. The addition of Cr in both forms increased the level of serotonin at a dose of 3 mg/kg and, at the same time, reduced the level of noradrenaline. The addition of Cr at 3 mg/kg, irrespective of the form used, regulated the level of hormones of carbohydrate metabolism (increasing insulin levels and reducing glucagon levels) and had an adverse effect on the antioxidant status of the liver and breast muscle. Due to the adverse effect of Cr at 3 mg/kg on the antioxidant status of chickens, this level of Cr should not be considered in both forms Cr-Pic and Cr-NP as a feed additive for broiler chickens. In the future, studies on the potential beneficial effects of Cr on the organism should take into account doses lower than 3 mg/kg. writing-original draft preparation, A.S.; Writing-Review and editing, K.O. and J.J.; Visualization, A.S.; Supervision, J.J.; Project administration, A.S., J.J. and K.O.; Funding acquisition, J.J. and K.O. All authors have read and agreed to the published version of the manuscript.

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Effect of a high-fat diet and chromium on hormones level and Cr retention in rats

Stępniowska

Tutaj

Juśkiewicz

et al. 2021

J Endocrinol Invest

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Aims The aim of the study was to determine how the administration of a high-fat diet supplemented with various forms of chromium to rats affects accumulation of this element in the tissues and levels of leptin, ghrelin, insulin, glucagon, serotonin, noradrenaline and histamine, as well as selected mineral elements. Methods The experiment was conducted on 56 male Wistar rats, which were divided into 8 experimental groups. The rats received standard diet or high fat diet (HFD) with addition of 0.3 mg/kg body weight of chromium(III) picolinate (Cr-Pic), chromium(III)-methioninate (Cr-Met), or chromium nanoparticles (Cr-NP). Results Chromium in organic forms was found to be better retained in the body of rats than Cr in nanoparticles form. However, Cr-Pic was the only form that increased the insulin level, which indicates its beneficial effect on carbohydrate metabolism. In blood plasma of rats fed a high-fat diet noted an increased level of serotonin and a reduced level of noradrenaline. The addition of Cr to the diet, irrespective of its form, also increased the serotonin level, which should be considered a beneficial effect. Rats fed a high-fat diet had an unfavourable reduction in the plasma concentrations of Ca, P, Mg and Zn. The reduction of P in the plasma induced by supplementation with Cr in the form of Cr-Pic or Cr-NP may exacerbate the adverse effect of a high-fat diet on the level of this element. Conclusion A high-fat diet was shown to negatively affect the level of hormones regulating carbohydrate metabolism (increasing leptin levels and decreasing levels of ghrelin and insulin).

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The Modulatory Role of Spinally Located Histamine Receptors in the Regulation of the Blood Glucose Level in D-Glucose-Fed Mice

Cited by 6 publications

References 22 publications

Effect of histamine receptors agonists or antagonists administered intracerebroventricularly and intrathecally on the blood glucose level in immobilization stress model

Effect of histamine receptors agonists or antagonists administered intracerebroventricularly and intrathecally on the blood glucose level in immobilization stress model

The Effect of Chromium Nanoparticles and Chromium Picolinate in the Diet of Chickens on Levels of Selected Hormones and Tissue Antioxidant Status

Effect of a high-fat diet and chromium on hormones level and Cr retention in rats

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