Evaluation of the antioxidant and anti-osteoporosis activities of chemical constituents of the fruits of Prunus mume

Extract from Prunus mume Sieb. et Zucc. Fruit Prevents LPS-induced Homotypic Aggregation of Monocytic THP-1 Cells via Suppression of Nitric Oxide Production and NF-κB Activation

“…Many chemical constituents have been isolated from Maesil extract including volatile compounds [27], hydroxycinnamic acid derivatives [26], citric acid derivative (mumefural) [7], and triterpenoids [16]. Maesil extract has been reported to show anticancer [1,13,30], antiviral [38], anti-microbial [29], anti-oxidant [37], and cardiovascular protective [35] effects. Maesil extract has been used pharmaceutically in folk medicine for antitussive, expectoration, antiemetic, antidiarrheal, anthelmintic, and antipyretic actions [26,37].…”

“…Maesil extract has been reported to show anticancer [1,13,30], antiviral [38], anti-microbial [29], anti-oxidant [37], and cardiovascular protective [35] effects. Maesil extract has been used pharmaceutically in folk medicine for antitussive, expectoration, antiemetic, antidiarrheal, anthelmintic, and antipyretic actions [26,37]. Despite the known beneficial effects of Maesil extract in chronic inflammatory diseases such as cancer and cardiovascular disease, there are very few reports concerning its antiinflammatory effects and the detailed mechanisms involved.…”

Antiosteoporotic and antioxidant activities of diterpenoids from the Vietnamese soft corals Sinularia maxima and Lobophytum crassum

“…Under these conditions, an imbalance between ROS production and antioxidant mechanisms may be disturbed, resulting in oxidative stress that could lead to osteoporosis (Abdollahi et al, 2005). More recent studies have suggested that the intracellular antioxidant activity of scavenging ROS may be responsible for enhanced suppression (Abdollahi et al, 2005;Wilson, 2014) of preosteoclastic RAW 264.7 cell differentiation into osteoclasts (Brayboy et al, 2001;Lee et al, 2013;Muhammad et al 2012;Suh et al, 2013;Yan et al, 2014). To our knowledge, there is a lack of scientific data regarding the antiosteoporotic activity of marine-derived compounds from soft corals, prompting us to undertake the present study (Cuong et al, 2008).…”

Prunus mume Sieb. et Zucc. fruit ameliorates alcoholic liver injury in mice by inhibiting apoptosis and inflammation through oxidative stress

“…Most of the constituents have been reported as bioactive compounds with antioxidant effect and thus protective against oxidative stressrelated diseases (Khallouki, Haubner, Erben, Ulrich, & Owen, 2012;Kono et al, 1997;Nakatani et al, 2000;Niggeweg, Michael, & Martin, 2004;Xia et al, 2010;Yan et al, 2014). Other beneficial effects of the compounds were also reported as follows: anti-osteoporosis (Yan et al, 2014), anticancer (Jeong, Moon, Park, & Shin, 2006;Kasai, Fukada, Yamaizumi, Sugie, & Mori, 2000), antiplasmodial (Verotta et al, 2001), antidiabetic (Ong, Hsu, & Tan, 2013), anti-lipidaemic (Ong et al, 2013), antiinflammatory (Santos, Almeida, Lopes, & Souza, 2006), antipyretic (Santos et al, 2006), hypoglycaemic effects (Nicasio, Auilar-Santamaria, Aranda, Ortiz, & Gonzalez, 2005), detoxifying enzyme activity (Feng et al, 2005), and improvement of insulin sensitivity (Sotillo & Hadley, 2002). Four out of eight constituents we identified in PME were isomers of CGA such as cis-NeoCGA, NeoCGA, and 3-feruloylquinic acid (methyl ester CGA).…”