Re: Defining Progression in Nonmuscle Invasive Bladder Cancer: It is Time for a New, Standard Definition

Bryan, Richard T.; Cheng, Kar Keung; James, Nicholas D.; Wallace, DM

doi:10.1016/j.juro.2014.01.011

Cited by 1 publication

(1 citation statement)

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“…Patients that progressed from T1 to T2 disease were not counted as a recurrence but as a progression event. Unfortunately, there were not enough events to also consider biological progression within this sample of NMIBC patients, as defined in the BCPP cohort [ 19 ]. Therefore, this study only focussed on confirmed recurrence events and patients who experienced a progression event were censored in the survival analysis when the progression event was diagnosed.…”

Section: Methodsmentioning

confidence: 99%

The association between smoking cessation before and after diagnosis and non-muscle-invasive bladder cancer recurrence: a prospective cohort study

Osch

Jochems

Reulen

et al. 2018

Cancer Causes Control

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BackgroundSmoking is a major risk factor for bladder cancer, but the relationship between smoking cessation after initial treatment and bladder cancer recurrence has been investigated less frequently and not prospectively yet.Methods722 non-muscle-invasive bladder cancer (NMIBC) patients (pTa, pT1, and CIS) from the prospective Bladder Cancer Prognosis Programme (BCPP) cohort, selected in the UK between 2005 and 2011, provided complete data on smoking behavior before and up to 5 years after diagnosis. The impact of smoking behavior on NMIBC recurrence was explored by multivariable Cox regression models investigating time-to-first NMIBC recurrence.ResultsOver a median follow-up period of 4.21 years, 403 pathologically confirmed NMIBC recurrences occurred in 210 patients. Only 25 current smokers at diagnosis quit smoking (14%) during follow-up and smoking cessation after diagnosis did not decrease risk of recurrence compared to continuing smokers (p = 0.352).ConclusionsAlthough quitting smoking after diagnosis might reduce the risk of recurrence based on retrospective evidence, this is not confirmed in this prospective study because the number of NMIBC patients quitting smoking before their first recurrence was too low. Nevertheless, this indicates an important role for urologists and other health care professionals in promoting smoking cessation in NMIBC.

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Section: Methodsmentioning

confidence: 99%