High grade primitive neuroectodermal tumor of the uterus: A case report

Dizon, A. Mitch; Kilgore, Larry C.; Grindstaff, Alan D.; Winkler, Marcus; Kimball, Kristopher J.

doi:10.1016/j.gynor.2013.10.002

Cited by 14 publications

(10 citation statements)

References 15 publications

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“…The most common site of extraosseous PNET in the female genital tract is the ovaries followed by the uterine corpus. To date, less than 50 relevant cases have been previously described as ‘uterine ES/pPNET’; however, only seven cases were subjected to molecular analysis for confirmation of that diagnosis. Tumors without an EWSR1 gene rearrangement should be characterized as uterine tumors with neuroectodermal differentiation or, alternatively, as cPNET rather than pPNET…”

Section: Instructionmentioning

confidence: 99%

Ewing's sarcoma/peripheral primitive neuroectodermal tumors of the uterus confirmed with fluorescence in situ hybridization in a 29‐year‐old Chinese female: A case report and published work review

Wang

Lin

et al. 2014

J of Obstet and Gynaecol

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Ewing's sarcoma/peripheral primitive neuroectodermal tumors (ES/pPNET) are a group of small round cell sarcomas that show varying degrees of neuroectodermal differentiation characterized by translocation involving the EWS gene. Uterine ES/pPNET is a rare entity. A 29-year-old Chinese female who presented with abdominal swelling and pain was diagnosed with a primary uterine ES/pPNET on the basis of clinicopathologic, immunohistochemical and fluorescence in situ hybridization (FISH) data. She was given a multimodal treatment, including neoadjuvant, 95% cytoreductive, chemotherapy and radiotherapy. The patient is currently alive with persistent disease after 18 months of follow-up. We emphasized the crucial role of molecular techniques in the differential diagnosis of small round cell tumors in this unusual location. Multimodal therapy may improve the outcomes of patients.

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Section: Instructionmentioning

confidence: 99%

Ewing's sarcoma/peripheral primitive neuroectodermal tumors of the uterus confirmed with fluorescence in situ hybridization in a 29‐year‐old Chinese female: A case report and published work review

Wang

Lin

et al. 2014

J of Obstet and Gynaecol

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“…To date, over 64 cases of primary uterine PNET have been reported in the literature (Ng, 2002, Dizon et al, 2013, Novo et al, 2015), the largest being a seventeen-patient case series by Euscher et al (2008).…”

Section: Introductionmentioning

confidence: 99%

Primitive neuroectodermal tumor of the uterus

Elizalde

Yagüe

Fernández

et al. 2016

Gynecologic Oncology Reports

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“…Reports with incomplete information about chemotherapy were also excluded. Of a total of 178 papers identified from the search terms in the MEDLINE database, 49 cases fulfilled the mentioned criteria (Table ). We analyzed the choice of chemotherapy regimen in relation to the patients’ ages and divided patients into the following groups: adolescence (<20 years), reproductive (20–40 years), premenopausal (40–60 years) and elderly (>60 years).…”

Section: Discussionmentioning

confidence: 99%

Adjuvant chemotherapy for a primitive neuroectodermal tumor of the uterine corpus: A case report and literature review

Akazawa

Saito

Ariyoshi

et al. 2018

J of Obstet and Gynaecol

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A primitive neuroectodermal tumor (PENT) belongs to the category of a Ewing sarcoma. A PENT of the uterus is rare and has been known to be very aggressive by nature. Owing to the rarity of the tumor, there is no optimal treatment at present. In many cases, after hysterectomy, chemotherapy or radiation therapy has been performed. However, an effective chemotherapy regimen was unclear. In the soft tissue sarcoma area, the chemotherapy approach has recently greatly improved. Vincristine, doxorubicin, cyclophosphamide, ifosfamide and etoposide (VDC-IE) therapy has improved the survival rate of patients with Ewing sarcoma/PENT. Thus, VDC-IE therapy may be used for a uterine PENT. Here, we report a case of a uterine PENT in a premenopausal woman successfully treated with multimodality treatment including VDC-IE therapy and discuss the optimal chemotherapy for a uterine PENT through a literature review.

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High grade primitive neuroectodermal tumor of the uterus: A case report

Abstract: HighlightsPrimitive neuroectodermal tumor of the uterus is extremely rare.Diagnosis requires timely evaluation with molecular analysis.Different combinations of adjuvant chemotherapy have been reported.

Cited by 14 publications

References 15 publications

Ewing's sarcoma/peripheral primitive neuroectodermal tumors of the uterus confirmed with fluorescence in situ hybridization in a 29‐year‐old Chinese female: A case report and published work review

Ewing's sarcoma/peripheral primitive neuroectodermal tumors of the uterus confirmed with fluorescence in situ hybridization in a 29‐year‐old Chinese female: A case report and published work review

Primitive neuroectodermal tumor of the uterus

Adjuvant chemotherapy for a primitive neuroectodermal tumor of the uterine corpus: A case report and literature review

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