Can a combination of handgrip exercise and prolonged forearm occlusion elicit a maximal brachial artery FMD response?

Ku, Jennifer; McEvoy, Alana; Pyke, Kyra E.

doi:10.1007/s00421-014-2859-0

Cited by 3 publications

(3 citation statements)

References 39 publications

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“…Lengthening the duration of occlusion can prolong the shear stress stimulus created by reactive hyperemia. This typically yields a larger FMD response than the standard 5 min-RH test (Ku et al 2014;Mullen et al 2001), and has been minimally studied with respect to its ability to detect endothelial dysfunction in a variety of populations (Mullen et al 2001). Handgrip exercise (HGEX) elicits a sustained, intensity-dependent increase in brachial artery shear stress (Findlay et al 2013;Pyke et al 2008b;Wray et al 2006).…”

Section: R a F T Introductionmentioning

confidence: 99%

Impaired handgrip exercise-induced brachial artery flow-mediated dilation in young obese males

Slattery

Stuckless

King

et al. 2016

Appl. Physiol. Nutr. Metab.

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Flow mediated dilation (FMD) stimulated by different shear stress stimulus profiles may recruit distinct transduction mechanisms, and provide distinct information regarding endothelial function. The purpose of this study was to determine whether obesity influences brachial artery FMD differently depending on the shear stress profile used for FMD assessment. The FMD response to a brief, intermediate, and sustained shear stress profile was assessed in obese (n = 9) and lean (n = 19) young men as follows: brief stimulus, standard reactive hyperemia (RH) following a 5 min forearm occlusion (5 min RH); intermediate stimulus, RH following a 15 min forearm occlusion (15 min RH); sustained stimulus, 10 min of handgrip exercise (HGEX). Brachial artery diameter and mean shear stress were assessed using echo and Doppler ultrasound, respectively, during each FMD test. There was no group difference in HGEX shear stress (p = 0.390); however, the obese group had a lower HGEX-FMD (5.2 ± 3.0% versus 11.5 ± 4.4%, p < 0.001). There was no group difference in 5 min RH-FMD (p = 0.466) or 15 min RH-FMD (p = 0.181); however, the shear stress stimulus was larger in the obese group. After normalization to the stimulus the 15 min RH-FMD (p = 0.002), but not the 5 min RH-FMD (p = 0.118) was lower in the obese group. These data suggest that obesity may have a more pronounced impact on the endothelium's ability to respond to prolonged increases in shear stress.

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Section: R a F T Introductionmentioning

confidence: 99%

Impaired handgrip exercise-induced brachial artery flow-mediated dilation in young obese males

Slattery

Stuckless

King

et al. 2016

Appl. Physiol. Nutr. Metab.

Self Cite

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“…Furthermore, as RH is variable between individuals or following a stressor, the stimulus–response relationship in FMD needs to be interpreted critically. In this context, a minor change in FMD could be related to the resistance artery function as opposed to a macrovascular dysfunction (Ku et al., 2014 ; Mitchell et al., 2004 ; Wray et al., 2006 ).…”

Section: Discussionmentioning

confidence: 99%

Arterial function in response to a 50 km ultramarathon in recreational athletes

Ranadive,

Weiner,

Eagan

et al. 2024

Experimental Physiology

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This study was performed to determine whether prolonged endurance running results in acute endothelial dysfunction and wave‐reflection, as endothelial dysfunction and arterial stiffness are cardiovascular risk factors. Vascular function (conduit artery/macrovascular and resistance artery/microvascular) was assessed in 11 experienced runners (8 males, 3 females) before, during and after a 50 km ultramarathon. Blood pressure (BP), heart rate (HR), wave reflection, augmentation index (AIx) and AIx corrected for HR (AIx75) were taken at all time points—Baseline (BL), following 10, 20, 30 and 40 km, 1 h post‐completion (1HP) and 24 h post‐completion (24HP). Flow‐mediated dilatation (FMD) and inflammatory biomarkers were examined at BL, 1HP and 24HP. Reactive hyperaemia area under the curve (AUC) and shear rate AUC to peak dilatation were lower (∼75%) at 1HP compared with BL (P < 0.001 for both) and reactive hyperaemia was higher at 24HP (∼27%) compared with BL (P = 0.018). Compared to BL, both mean central systolic BP and mean central diastolic BP were 7% and 10% higher, respectively, following 10 km and 6% and 9% higher, respectively, following 20 km, and then decreased by 5% and 8%, respectively, at 24HP (P < 0.05 for all). AIx (%) decreased following 20 km and following 40 km compared with BL (P < 0.05 for both) but increased following 40 km when corrected for HR (AIx75) compared with BL (P = 0.02). Forward wave amplitude significantly increased at 10 km (15%) compared with BL (P = 0.049), whereas backward wave reflection and reflected magnitude were similar at all time points. FMD and baseline diameter remained similar. These data indicate preservation of macrovascular (endothelial) function, but not microvascular function resulting from the 50 km ultramarathon.

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“…Occlusion and handgrip exercise for a long duration induces shear stress stimuli on the upper limit of the brachial artery (BA) and flowmediated dilation (FMD). The stimulus created by brief occlusion and ischemic exercise is not increased by prolonging the occlusion or continuing to exercise post-occlusion [27].…”

Section: Parameters During Exercisementioning

confidence: 96%

A Subject-Tailored Variability-Based Platform for Overcoming the Plateau Effect in Sports Training: A Narrative Review

Gelman

Berg

Ilan

2022

IJERPH

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The plateau effect in training is a significant obstacle for professional athletes and average subjects. It evolves from both the muscle-nerve-axis-associated performance and various cardiorespiratory parameters. Compensatory adaptation mechanisms contribute to a lack of continuous improvement with most exercise regimens. Attempts to overcome this plateau in exercise have been only partially successful, and it remains a significant unmet need in both healthy subjects and those suffering from chronic neuromuscular, cardiopulmonary, and metabolic diseases. Variability patterns characterize many biological processes, from cellular to organ levels. The present review discusses the significant obstacles in overcoming the plateau in training and establishes a platform to implement subject-tailored variability patterns to prevent and overcome this plateau in muscle and cardiorespiratory performance.

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Can a combination of handgrip exercise and prolonged forearm occlusion elicit a maximal brachial artery FMD response?

Cited by 3 publications

References 39 publications

Impaired handgrip exercise-induced brachial artery flow-mediated dilation in young obese males

Impaired handgrip exercise-induced brachial artery flow-mediated dilation in young obese males

Arterial function in response to a 50 km ultramarathon in recreational athletes

A Subject-Tailored Variability-Based Platform for Overcoming the Plateau Effect in Sports Training: A Narrative Review

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