A new potential approach to block HIV-1 replication via protein–protein interaction and strand-transfer inhibition

Ferro, Stefania; Luca, Laura De; Surdo, Giuseppa Lo; Morreale, Francesca; Christ, Frauke; Debyser, Zeger; Gitto, Rosaria; Chimirri, Alba

doi:10.1016/j.bmc.2014.02.012

Cited by 15 publications

(5 citation statements)

References 38 publications

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“…As a continuation of our previous studies on anti‐HIV agents and in particular on HIV‐IN enzyme inhibitors,,, herein we report the results of a research on PPIIs.…”

Section: Resultsmentioning

confidence: 87%

Rational Design, Synthesis and Evaluation of Coumarin Derivatives as Protein‐protein Interaction Inhibitors

Luca

Agharbaoui

Gitto

et al. 2016

Molecular Informatics

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Herein we describe the design and synthesis of a new series of coumarin derivatives searching for novel HIV-1 integrase (IN) allosteric inhibitors. All new obtained compounds were tested in order to evaluate their ability to inhibit the interaction between the HIV-1 IN enzyme and the nuclear protein lens epithelium growth factor LEDGF/p75. A combined approach of docking and molecular dynamic simulations has been applied to clarify the activity of the new compounds. Specifically, the binding free energies by using the method of molecular mechanics-generalized Born surface area (MM-GBSA) was calculated, whereas hydrogen bond occupancies were monitored throughout simulations methods.

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“…As a continuation of our previous studies on anti‐HIV agents and in particular on HIV‐IN enzyme inhibitors,,, herein we report the results of a research on PPIIs.…”

Section: Resultsmentioning

confidence: 87%

Rational Design, Synthesis and Evaluation of Coumarin Derivatives as Protein‐protein Interaction Inhibitors

Luca

Agharbaoui

Gitto

et al. 2016

Molecular Informatics

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“…Experimental approaches of relevance, although still in early stages, include: (i) inhibition of viral DNA integration into the host genome is accomplished by preventing PIC transport into the nucleus. This is put into practice by integrase-mediated nuclear import inhibitors, which bind to the host cell's nuclear import protein [142]; (ii) IN-mediated chromatin remodeling inhibitors (ICRIs). In this case, inhibition of v-DNA integration into the host genome by preventing the opening of the chromatin structure is targeted by the host cell's chromatin remodeling factors [143].…”

Section: New Strategies Against Retrovirus Resistancementioning

confidence: 99%

The Integrase: An Overview of a Key Player Enzyme in the Antiviral Scenario

Renzi,

Carta,

Supuran

2023

IJMS

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Integration of a desossiribonucleic acid (DNA) copy of the viral ribonucleic acid (RNA) into host genomes is a fundamental step in the replication cycle of all retroviruses. The highly conserved virus-encoded Integrase enzyme (IN; EC 2.7.7.49) catalyzes such a process by means of two consecutive reactions named 3′-processing (3-P) and strand transfer (ST). The Authors report and discuss the major discoveries and advances which mainly contributed to the development of Human Immunodeficiency Virus (HIV) -IN targeted inhibitors for therapeutic applications. All the knowledge accumulated over the years continues to serve as a valuable resource for the design and development of effective antiretroviral drugs.

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“…Based on the previously obtained SAR information and benzylindole derivatives (97,98) as anti-HIV agents, Stefania Ferro and coworkers reported their research on the identification of new dual target small molecules able to target different steps of HIV-1 life cycle (Fig. 25), and obtained two series of novel anti-HIV agents (105,106), some of which are dual inhibitors of the integration process acting both in the IN strand-transfer step and by disrupting the proteineprotein interaction between IN and its cofactor LEDGF/ p75, and compound 107 is the most active one [92].…”

Section: Indole Derivatives As Integrase (In) Inhibitorsmentioning

confidence: 99%

A review on recent developments of indole-containing antiviral agents

Zhang

Chen

Yang

2015

European Journal of Medicinal Chemistry

704

215

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Indole represents one of the most important privileged scaffolds in drug discovery. Indole derivatives have the unique property of mimicking the structure of peptides and to bind reversibly to enzymes, which provide tremendous opportunities to discover novel drugs with different modes of action. There are seven indole-containing commercial drugs in the Top-200 Best Selling Drugs by US Retail Sales in 2012. There are also an amazing number of approved indole-containing drugs in the market as well as compounds currently going through different clinical phases or registration statuses. This review focused on the recent development of indole derivatives as antiviral agents with the following objectives: 1) To present one of the most comprehensive listings of indole antiviral agents, drugs on market or compounds in clinical trials; 2) To focus on recent developments of indole compounds (including natural products) and their antiviral activities, summarize the structure property, hoping to inspire new and even more creative approaches; 3) To offer perspectives on how indole scaffolds as a privileged structure might be exploited in the future.

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A new potential approach to block HIV-1 replication via protein–protein interaction and strand-transfer inhibition

Cited by 15 publications

References 38 publications

Rational Design, Synthesis and Evaluation of Coumarin Derivatives as Protein‐protein Interaction Inhibitors

Rational Design, Synthesis and Evaluation of Coumarin Derivatives as Protein‐protein Interaction Inhibitors

The Integrase: An Overview of a Key Player Enzyme in the Antiviral Scenario

A review on recent developments of indole-containing antiviral agents

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