Second European evidence-based consensus on the prevention, diagnosis and management of opportunistic infections in inflammatory bowel disease

Rahier, Jean–François; Magro, Fernando; Abreu, Cândida; Armuzzi, Alessandro; Ben‐Horin, Shomron; Chowers, Yehuda; Cottone, Mario; Ridder, Lissy de; Doherty, Glen; Ehehalt, Robert; Esteve, María; Κατσάνος, Κωνσταντίνος; Lees, Charlie W; MacMahon, Eithne; Moreels, Tom G.; Reinisch, Walter; Tilg, Herbert; Tremblay, Lydjie; Veereman-Wauters, G.; Viget, N.; Yazdanpanah, Yazdan; Eliakim, Rami; Colombel, Jean Fréd́eric

doi:10.1016/j.crohns.2013.12.013

Cited by 839 publications

(1,081 citation statements)

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“…Patienten mit entzündlichen Darmerkrankungen (IBD) sind ohne Therapie durch die Krankheit allein nicht immunsupprimiert [114]. Eine Immunsuppression bei diesen Patienten entsteht durch eine Therapie mit Kortikosteroiden (Lebenszeitwahrscheinlichkeit 80 %), Immunsuppressiva (Lebenszeitwahrscheinlichkeit 40 %) oder TNFα-Blockern (Lebenszeitwahrscheinlichkeit 20 %), gelegentlich auch durch Malnutrition (heute selten) und ev.…”

Section: Gastroenterologie/entzündliche Darmerkrankungenunclassified

“…Eine Immunsuppression bei diesen Patienten entsteht durch eine Therapie mit Kortikosteroiden (Lebenszeitwahrscheinlichkeit 80 %), Immunsuppressiva (Lebenszeitwahrscheinlichkeit 40 %) oder TNFα-Blockern (Lebenszeitwahrscheinlichkeit 20 %), gelegentlich auch durch Malnutrition (heute selten) und ev. durch Komorbiditäten oder höheres Lebensalter [114,115].…”

Section: Gastroenterologie/entzündliche Darmerkrankungenunclassified

“…6-Mercaptopurin, Methotrexat oder TNFα-Blockern gelten als immunsupprimiert und sollten keine Lebendimpfungen erhalten [114]. Eine Therapie mit Vedolizumab (Integrin-Antagonist) ist laut Label ebenfalls in diese Gruppe einzureihen [118].…”

Section: Gastroenterologie/entzündliche Darmerkrankungenunclassified

“…Patienten, die unter kombinierter Immunsuppression (i. v. Steroide, Ciclosporin A, Infliximab) stehen, sollten keine Impfungen bekommen [114].…”

Section: Gastroenterologie/entzündliche Darmerkrankungenunclassified

“…Unter immunsuppressiver Kombinationstherapie ist das Risiko für eine disseminierte VZV-Infektion erhöht [120]. Deshalb sollten alle immunkompetenten IBD-Patienten spätestens einen Monat vor Beginn oder frühestens drei Monate nach Ende der ISP gegen VZV geimpft werden, sofern keine Immunität vorliegt [114].…”

Section: Gastroenterologie/entzündliche Darmerkrankungenunclassified

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Impfungen bei Immundefekten/Immunsuppression – Expertenstatement und Empfehlungen

Wiedermann

Sitte

Burgmann

et al. 2016

Wien Klin Wochenschr

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Section: Gastroenterologie/entzündliche Darmerkrankungenunclassified

“…Patienten, die unter kombinierter Immunsuppression (i. v. Steroide, Ciclosporin A, Infliximab) stehen, sollten keine Impfungen bekommen [114].…”

Section: Gastroenterologie/entzündliche Darmerkrankungenunclassified

See 3 more Smart Citations

Impfungen bei Immundefekten/Immunsuppression – Expertenstatement und Empfehlungen

Wiedermann

Sitte

Burgmann

et al. 2016

Wien Klin Wochenschr

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Development of Cancer Among Patients With Pediatric-Onset Inflammatory Bowel Disease

et al. 2022

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IMPORTANCEBecause the incidence of pediatric-onset inflammatory bowel disease (IBD) is increasing, knowledge of the long-term risk of cancer in this patient population is required. OBJECTIVE To evaluate the relative rate of cancer among patients with pediatric-onset IBD. DATA SOURCES A comprehensive systematic search was performed of MEDLINE and Embase from the date of database inception to October 31, 2021. STUDY SELECTION All unselected, population-based cohort studies of pediatric-onset IBD assessing the risk of cancer were included. Tertiary center referrals and insurance database studies were excluded. All articles were assessed by 2 independent reviewers. DATA EXTRACTION AND SYNTHESISThe study followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses reporting guideline for data extraction and used the Newcastle-Ottawa Scale for assessment of the risk of bias and the quality of included articles. MAIN OUTCOMES AND MEASURESA random-effects model meta-analysis was conducted of included studies using the inverse-variance method to assess the relative rate of cancer overall and by IBD subtype (Crohn disease or ulcerative colitis), sex, and thiopurine exposure among patients with pediatric-onset IBD. Pooled relative rates (pRRs) along with 95% CIs were calculated for combined studies. RESULTSOf 4628 articles screened, 5 population-based studies from North America and Europe were eligible for inclusion. These studies comprised 19 812 individuals with pediatric-onset IBD followed up for 283 540 person-years in which 715 cases of cancer were identified. Meta-analysis of pRR estimates showed a 2.4-fold increased rate of cancer among patients with pediatric-onset IBD (pRR, 2.46; 95% CI, 2.06-2.93), seen among patients with Crohn disease (pRR, 2.03; 95% CI, 1.67-2.46) and those with ulcerative colitis (pRR, 2.61; 95% CI, 2.00-3.40). This increased rate is primarily due to an increased rate of liver (

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Alteration of glucocorticoid receptors and exacerbation of inflammation during lytic cytomegalovirus infection in THP‐1 cells

et al. 2017

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Cytomegalovirus ( CMV ) infection is associated with glucocorticoid resistance in ulcerative colitis (UC) and may exacerbate the disease course. However, the underlying pathogenicity remains unclear. The aim of this study was to explore possible underlying mechanisms during CMV latency and lytic infection in the human mononuclear cell line THP ‐1. Latent and activated CMV infection cell models were established. We performed real‐time PCR and western blotting to examine changes in glucocorticoid receptors ( GR s) during CMV latency and activation. Pro‐inflammatory and anti‐inflammatory cytokines were detected by ELISA . After UV ‐inactivated CMV infection, GRs and cytokines were also examined. The expression of GR s was elevated in the reactivation group. An increased ratio of GR β/α and phosphorylation of GR α in the CMV reactivation group may explain refractory response to steroids. During CMV lytic infection, pro‐inflammatory cytokines IL ‐6 and TNF ‐α increased remarkably and anti‐inflammatory cytokine IL ‐5 decreased, which may exacerbate UC. GR and cytokines were unchanged in the UV ‐inactivated CMV infection group. Changes in the number and function of GR s may account for glucocorticoid resistance in CMV reactivation. The imbalance of pro‐ and anti‐inflammatory cytokines may be related to severe inflammation.

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Second European evidence-based consensus on the prevention, diagnosis and management of opportunistic infections in inflammatory bowel disease

Cited by 839 publications

References 0 publications

Impfungen bei Immundefekten/Immunsuppression – Expertenstatement und Empfehlungen

Impfungen bei Immundefekten/Immunsuppression – Expertenstatement und Empfehlungen

Development of Cancer Among Patients With Pediatric-Onset Inflammatory Bowel Disease

Alteration of glucocorticoid receptors and exacerbation of inflammation during lytic cytomegalovirus infection in THP‐1 cells

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