Expression of <scp>IFN</scp>‐<i>γ</i>,<scp> IL</scp>‐4, and <scp>IL</scp>‐17 in cutaneous schistosomal granuloma

Attia, Sameh K.; Moftah, Noha H.; Abdel-Azim, Eman S.

doi:10.1111/ijd.12464

Cited by 7 publications

(8 citation statements)

References 40 publications

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“…The intensity of the stain was subjectively evaluated (mild: light staining, moderate: moderate staining or strong: intense staining). With regarding the inflammatory cells in dermis, they were also assessed for positivity, percentage of positive cells and the staining intensity of both the primary studied antibodies (IL‐17A and FOXP3) 14 …”

Section: Methodsmentioning

confidence: 99%

Tissue expression of IL‐17A and FOXP3 in acne vulgaris patients

Farag

Maraee

Al-Sharaky

et al. 2020

J of Cosmetic Dermatology

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Acne vulgaris presently assumed as a chronic inflammatory disorder of the pilosebaceous component. 1 It is considered the most prevalent worldwide disease as it affects, in the developed countries, 85% of adolescents and about 9.4% of the world's population. 2 AV is a result of interplay of androgen-induced augmented sebum secretion, follicular hyperkeratinisation, loss of skin microbial diversity (colonization by propionibacterium acnes, P. acne) and inflammatory reactions plus altered adaptive immune reaction. 1

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Section: Methodsmentioning

confidence: 99%

Tissue expression of IL‐17A and FOXP3 in acne vulgaris patients

Farag

Maraee

Al-Sharaky

et al. 2020

J of Cosmetic Dermatology

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“…While the urologic and gastrointestinal forms of infection receive adequate coverage in the infectious disease literature, the cutaneous forms of disease are much less emphasized, even within dermatology training programs. These entities present a diagnostic challenge when encountered in non‐tropical climates where schistosomiasis is rare 30–31 …”

Section: Cutaneous Diseasementioning

confidence: 99%

“…Late cutaneous schistosomiasis is a result of a granulomatous reaction to deposition of eggs in the dermis that manifests several months after infection 33 . When an adult female worm travels an aberrant route to the skin and deposits an egg, an inflammatory cascade follows that results in the formation of distinctive granulomas months after exposure 31 . Eggs reach the skin because of portosystemic anastomoses via the inferior mesenteric vein and rectal venous plexus 36 .…”

Section: Cutaneous Diseasementioning

confidence: 99%

“…These entities present a diagnostic challenge when encountered in non-tropical climates where schistosomiasis is rare. [30][31] Cutaneous involvement has generally been classified into three clinical syndromes depending on the chronology of the infection: immediate, early, or chronic. 32 Each of these has its own pathophysiology and distinct clinical presentation.…”

Section: Cutaneous Diseasementioning

confidence: 99%

“…33 When an adult female worm travels an aberrant route to the skin and deposits an egg, an inflammatory cascade follows that results in the formation of distinctive granulomas months after exposure. 31 Eggs reach the skin because of portosystemic anastomoses via the inferior mesenteric vein and rectal venous plexus. 36 These lesions cause late cutaneous schistosomiasis, also known as bilharziasis cutanea tarda (BCT).…”

Section: Cutaneous Diseasementioning

confidence: 99%

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Cutaneous schistosomiasis: epidemiological and clinical characteristics in returning travelers

Marks

2022

Int J Dermatology

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The clinical manifestations of parasitic diseases are well‐covered in the infectious disease literature; however, cutaneous manifestations often receive limited attention. There is a need to update existing knowledge and improve reporting of disease characteristics. Given continued increases in travel and transportation, more individuals are acquiring cutaneous infections while traveling abroad. Schistosomiasis is the second most important tropical disease among returning travelers and affects more than 200 million individuals worldwide. The literature classically describes three forms of skin disease in those infected with Schistosoma: the immediate pruritic eruption of cercarial dermatitis, the urticarial response of Katayama syndrome, and the granulomatous lesions of late cutaneous schistosomiasis. Over the last two decades, more atypical presentations have been described. Travelers returning from Africa, South America, and Asia are at highest risk given these are the continents in which the parasite is endemic. This review highlights the cutaneous manifestations of schistosomiasis, with a focus on international travelers with atypical presentations. Additionally, genital schistosomiasis will be reviewed given its significant morbidity. The aim of this review is to update the current body of literature. Dermatologists and other physicians evaluating the skin should be aware of the following principles regarding schistosomal infections: (i) the importance of an early skin biopsy in making the diagnosis; (ii) the necessity of adding schistosomiasis to the differential diagnosis for zosteriform lesions; (iii) the resemblance of chronic cutaneous schistosomiasis of the genitals to sexually transmitted infections; and (iv) the need to revise definitions for early and late infection, specifically for cutaneous disease.

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IL‐23/IL‐17 immune axis mediates the imiquimod‐induced psoriatic inflammation by activating ACT1/TRAF6/TAK1/NF‐κB pathway in macrophages and keratinocytes

Chen

Wen

Wang

et al. 2023

The Kaohsiung J of Med Scie

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The interleukin‐23 (IL‐23)/IL‐17 immune axis has been linked to the pathology of psoriasis, but how this axis contributes to skin inflammation in this disease remains unclear. We measured inflammatory cytokines associated with the IL‐23/IL‐17 immune axis in the serum of patients with psoriasis using enzyme‐linked immunosorbent assays. Psoriasis was induced in male C57BL/6J mice using imiquimod (IMQ) cream, and animals received intraperitoneal injections of recombinant mouse anti‐IL‐23A or anti‐IL‐17A antibodies for 7 days. The potential effects of the IL‐23/IL‐17 immune axis on skin inflammation were assessed based on pathology scoring, hematoxylin–eosin staining of skin samples, and quantitation of inflammatory cytokines. Western blotting was used to evaluate levels of the following factors in skin: ACT1, TRAF6, TAK1, NF‐κB, and pNF‐κB. The serum of psoriasis patients showed elevated levels of several cytokines involved in the IL‐23/IL‐17 immune axis: IL‐2, IL‐4, IL‐8, IL‐12, IL‐17, IL‐22, IL‐23, and interferon‐γ. Levels of IL‐23p19 and IL‐17 were increased in serum and skin of IMQ‐treated mice, while ACT1, TRAF6, TAK1, NF‐κB, and pNF‐κB were upregulated in the skin. A large proportion of NF‐κB p65 localized in nucleus of involucrin+ cells in the epidermis and in F4/80+ cells of the dermis of psoriatic lesional skin. Treating these animals with anti‐IL‐23 or anti‐IL‐17 antibodies improved pathological score and immune imbalance, mitigated skin inflammation and downregulated ACT1, TRAF6, TAK1, NF‐κB, and pNF‐κB in skin. Our results suggest that skin inflammation mediated by the IL‐23/IL‐17 immune axis in psoriasis involves activation of the ACT1/TRAF6/TAK1/NF‐κB pathway in keratinocytes and macrophage.

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Expression of IFN‐γ, IL‐4, and IL‐17 in cutaneous schistosomal granuloma

Abstract: This study suggests that CSG is formed by the action of both Th1 (IFN-γ) and Th17 (IL-17) cytokines, which have been shown to be directed against the schistosomal egg to induce a cell-mediated immune response.

Cited by 7 publications

References 40 publications

Tissue expression of IL‐17A and FOXP3 in acne vulgaris patients

Tissue expression of IL‐17A and FOXP3 in acne vulgaris patients

Cutaneous schistosomiasis: epidemiological and clinical characteristics in returning travelers

IL‐23/IL‐17 immune axis mediates the imiquimod‐induced psoriatic inflammation by activating ACT1/TRAF6/TAK1/NF‐κB pathway in macrophages and keratinocytes

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