Uterine Neoplasms, Version 1.2014

Abstract

Adenocarcinoma of the endometrium (also known as endometrial cancer or more broadly as uterine cancer or carcinoma of the uterine corpus) is the most common malignancy of the female genital tract in the United States. An estimated 49,560 new uterine cancer cases will occur in 2013, with 8190 deaths resulting from the disease. Uterine sarcomas (stromal/mesenchymal tumors) are uncommon malignancies, accounting for approximately 3% of all uterine cancers. The NCCN Guidelines for Uterine Neoplasms describe malignant epithelial carcinomas and uterine sarcomas; each of these major categories contains specific histologic groups that require different management. This excerpt of these guidelines focuses on early-stage disease.

Evaluation of Gynecologic Cancer with MR Imaging, 18F-FDG PET/CT, and PET/MR Imaging

“…The FIGO system stages endometrial cancer surgically (Supplemental Table 1) (2), and imaging is not described. The NCCN guidelines for endometrial cancer work-up specify chest imaging and also mention MR imaging, CT, and 18 F-FDG PET as possible options to consider in patients suspected to have extrauterine disease (16). A European imaging society recommends MR imaging for treatment planning (17).…”

Site‐specific factors for cancer of the corpus uteri from SEER registries: Collaborative stage data collection system, version 1 and version 2

“…6,7 The majority of cancer cases of the corpus uteri are diagnosed as International Federation of Gynecology and Obstetrics (FIGO) stage I. 8 Among more aggressive histologies, such as clear cell adenocarcinoma and serous cancers, cases often present at a more advanced stage and with worse prognosis. In these instances curative surgery may not be a treatment option.…”

“…8 Biopsies are performed on areas of suspected metastases. Omentectomy is typically is reserved for more aggressive histologic subtypes.…”

Immunotherapy in Gynecologic Cancers

“…In general, the disease can be cured with surgery including staging procedures and radiotherapy [98,99]. For type II cancer and advanced stage disease, chemotherapy with carboplatin and paclitaxel is included in standard of care treatment [98,99]. For relapsed disease and stage IV disease, surgery can be applied, but in general, standard of care is systemic therapy, including endocrine therapy such as medroxy-progestine, tamoxifen, or aromatase inhibitors [100].…”

“…In general, the disease can be cured with surgery including staging procedures and radiotherapy [98,99]. For type II cancer and advanced stage disease, chemotherapy with carboplatin and paclitaxel is included in standard of care treatment [98,99].…”