The effect of delmopinol and fluoride on acid adaptation and acid production in dental plaque biofilms

Neilands, Jessica; Troedsson, Ulrika; Sjödin, Torgny; Davies, Julia R.

doi:10.1016/j.archoralbio.2013.12.008

Cited by 13 publications

(10 citation statements)

References 35 publications

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“…In contrast, an emerging understanding of the complexity of dental biofilm (Costerton 1995), supported by modern analytic technologies such as genomics, microbiomics and metabolomics, facilitated a change in approaching dental caries (Kolenbrander et al 2010) and the role of extracellular matrices (Koo et al 2013) has clarified how bacteria need particular conditions, like the population of a city, to thrive (Marsh 2005). The shift between stages of physiologic biofilm conditions and dysbiosis is a response to environmental pressures (Neilands et al 2014), a concept which invites management focussing on rebalancing and modulating the biofilm composition (Marsh 2006) and activity, and not attempting to eradicate the biofilm per se.…”

Section: Dental Cariesmentioning

confidence: 99%

A Century of Change towards Prevention and Minimal Intervention in Cariology

et al. 2019

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Better understanding of dental caries and other oral conditions has guided new strategies to prevent disease and manage its consequences at individual and public health levels. This article discusses advances in prevention and minimal intervention dentistry over the last century by focusing on some milestones within scientific, clinical, and public health arenas, mainly in cariology but also beyond, highlighting current understanding and evidence with future prospects. Dentistry was initially established as a surgical specialty. Dental caries (similar to periodontitis) was considered to be an infectious disease 100 years ago. Its ubiquitous presence and rampant nature—coupled with limited diagnostic tools and therapeutic treatment options—meant that these dental diseases were managed mainly by excising affected tissue. The understanding of the diseases and a change in their prevalence, extent, and severity, with evolutions in operative techniques, technologies, and materials, have enabled a shift from surgical to preventive and minimal intervention dentistry approaches. Future challenges to embrace include continuing the dental profession’s move toward a more patient-centered, evidence-based, less invasive management of these diseases, focused on promoting and maintaining oral health in partnership with patients. In parallel, public health needs to continue to, for example, tackle social inequalities in dental health, develop better preventive and management options for existing disease risk groups (e.g., the growing aging population), and the development of reimbursement and health outcome models that facilitate implementation of these evolving strategies. A century ago, almost every treatment involved injections, a drill or scalpel, or a pair of forceps. Today, dentists have more options than ever before available to them. These are supported by evidence, have a minimal intervention focus, and result in better outcomes for patients. The profession’s greatest challenge is moving this evidence into practice.

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Section: Dental Cariesmentioning

confidence: 99%

A Century of Change towards Prevention and Minimal Intervention in Cariology

et al. 2019

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“…The fluoride can reduce the proportion of S. mutans but increase S. oralis ( Streptococcus oralis ) in the dual-species biofilm, subsequently inhibiting the formation of cariogenic bacteria-dominant biofilms [ 62 ]. This phenomenon lasts during both the initial rapid and second slow release phases, which is called the biphasic pattern of fluoride release of GICs [ 63 , 64 , 65 , 66 ]. The release of fluoride showed a significant dependence on the experimental conditions applied, such as sterile broth, bacteria, and acid.…”

Section: Chemical Characteristics Of Dental Materialsmentioning

confidence: 99%

Influence of Dental Prosthesis and Restorative Materials Interface on Oral Biofilms

Huang

Zhou

et al. 2018

IJMS

139

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Oral biofilms attach onto both teeth surfaces and dental material surfaces in oral cavities. In the meantime, oral biofilms are not only the pathogenesis of dental caries and periodontitis, but also secondary caries and peri-implantitis, which would lead to the failure of clinical treatments. The material surfaces exposed to oral conditions can influence pellicle coating, initial bacterial adhesion, and biofilm formation, due to their specific physical and chemical characteristics. To define the effect of physical and chemical characteristics of dental prosthesis and restorative material on oral biofilms, we discuss resin-based composites, glass ionomer cements, amalgams, dental alloys, ceramic, and dental implant material surface properties. In conclusion, each particular chemical composition (organic matrix, inorganic filler, fluoride, and various metallic ions) can enhance or inhibit biofilm formation. Irregular topography and rough surfaces provide favorable interface for bacterial colonization, protecting bacteria against shear forces during their initial reversible binding and biofilm formation. Moreover, the surface free energy, hydrophobicity, and surface-coating techniques, also have a significant influence on oral biofilms. However, controversies still exist in the current research for the different methods and models applied. In addition, more in situ studies are needed to clarify the role and mechanism of each surface parameter on oral biofilm development.

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“…In recent years, many chemical agents have been reported to have effects on the metabolism of bacteria and the adherence of bacterial cells. Some, such as chlorhexidine [14][15][16][17], delmopinol [17,18], and triclosan [19], have shown potent inhibitory activities against the development and maturation of biofilm. It is generally believed that the mechanism of chlorhexidine bactericidal activity is the destruction of the serosa permeability barrier against bacterial cells.…”

Section: Chemical Agentsmentioning

confidence: 99%

Microbial Etiology and Prevention of Dental Caries: Exploiting Natural Products to Inhibit Cariogenic Biofilms

et al. 2020

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Dental caries is one of the most common microbe-mediated oral diseases in human beings. At present, the accepted etiology of caries is based on a four-factor theory that includes oral microorganisms, oral environment, host, and time. Excessive exposure to dietary carbohydrates leads to the accumulation of acid-producing and acid-resistant microorganisms in the mouth. Dental caries is driven by dysbiosis of the dental biofilm adherent to the enamel surface. Effective preventive methods include inhibiting the cariogenic microorganisms, treatment with an anti-biofilm agent, and sugar intake control. The goal is to reduce the total amount of biofilm or the levels of specific pathogens. Natural products could be recommended for preventing dental caries, since they may possess fewer side effects in comparison with synthetic antimicrobials. Herein, the mechanisms of oral microbial community development and functional specialization are discussed. We highlight the application of widely explored natural products in the last five years for their ability to inhibit cariogenic microorganisms.

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The effect of delmopinol and fluoride on acid adaptation and acid production in dental plaque biofilms

Cited by 13 publications

References 35 publications

A Century of Change towards Prevention and Minimal Intervention in Cariology

A Century of Change towards Prevention and Minimal Intervention in Cariology

Influence of Dental Prosthesis and Restorative Materials Interface on Oral Biofilms

Microbial Etiology and Prevention of Dental Caries: Exploiting Natural Products to Inhibit Cariogenic Biofilms

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