IgG Against Dengue Virus in Healthy Blood Donors, Zanzibar, Tanzania

Vairo, Francesco; Nicastri, Emanuele; Yussuf, Salma Masauni; Cannas, Angela; Meschi, Silvia; Mahmoud, Mwanakheir; Mohamed, Azza H.; Maiko, Paul Mohamed; Nardo, Pasquale De; Bevilacqua, Nazario; Castilletti, Concetta; Di, Antonino; Racalbuto, Vincenzo; Ippolito, Giuseppe

doi:10.3201/eid2003.130150

Cited by 35 publications

(41 citation statements)

References 9 publications

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“…Donors aged 30‐39 years (OR = 1.86; IC = 1.06‐2.55, P = .03) and 40‐49 years old (OR = 2.35; IC = 1.10‐5.05, P = .03) were more likely to be infected compared to younger donors. These findings are consistent with the reports in literature . They could be explained by repeated exposures over the time, to the risk of infection, for older donors.…”

Section: Discussionsupporting

confidence: 93%

“…We found higher prevalence compared to some other African countries that are not reported to have experienced recent outbreaks (50.6% in Tanzania and 43.6% in Ghana) …”

Section: Discussioncontrasting

confidence: 66%

“…21 Despite the endemo-epidemic character of DENV in Africa, [4][5][6] there are scarce data on DENV concerning blood transfusion. Surveys carried out in Zanzibar by Vairo et al 30 and in Ghana by Narkwa et al 31 showed seroprevalences among blood donors of 50.6% and 43.6%, respectively. In both studies, the authors reported high seroprevalence of DENV infection in donors living in urban areas.…”

Section: This Recent Rapid Expansion Throughout the World And In Burkinamentioning

confidence: 97%

“…Despite the endemo‐epidemic character of DENV in Africa, there are scarce data on DENV concerning blood transfusion. Surveys carried out in Zanzibar by Vairo et al . and in Ghana by Narkwa et al .…”

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confidence: 99%

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Seroprevalence and factors associated with IgG anti‐DENV positivity in blood donors in Burkina Faso during the 2016 dengue outbreak and implications for blood supply

Sawadogo

Baguiya

Yougbare

et al. 2019

Transfusion Medicine

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Summary Objectives Our study aimed to update the seroprevalence and factors associated with anti‐dengue virus (DENV) antibody positivity among blood donors and to discuss their implications for blood supply. Background Questions on the potential transmission of DENV by transfusion increased after the documentation of the risk of transmission of the West Nile virus. This risk was estimated after transfusion of DENV RNA‐positive blood units of up to 37.5%. In Burkina Faso, very few studies on DENV in blood donors have been conducted. As a result, there were no reliable data on DENV to allow the implementation of appropriate measures to control the risk of transmission of the dengue virus by blood transfusion. Methods We conducted a 4‐week cross‐sectional study from December 4 to 30, 2016. Blood donors of both genders, aged 18‐60 years, accepted for blood donation after medical selection were consecutively enrolled. Results Our study included a total of 1007 blood donors, in which donors living in urban areas represented 78.2%. The mean age was 26.1 ± 8.1 years. After adjustment in a multiple regression logistic model, the odds of having IgG anti‐DENV increased as age increased. The odds of DENV was 53% lower in rural areas (OR = 0.47; P = .000) compared to urban settings and 42% lower in mobile sites (OR = 0.58; P = .03) compared to fixed ones. Conclusion Our study provides new and useful insights for future research on the risk of TT‐DENV throughout blood transfusion.

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Section: Discussionsupporting

confidence: 93%

“…We found higher prevalence compared to some other African countries that are not reported to have experienced recent outbreaks (50.6% in Tanzania and 43.6% in Ghana) …”

Section: Discussioncontrasting

confidence: 66%

Section: This Recent Rapid Expansion Throughout the World And In Burkinamentioning

confidence: 97%

mentioning

confidence: 99%

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Seroprevalence and factors associated with IgG anti‐DENV positivity in blood donors in Burkina Faso during the 2016 dengue outbreak and implications for blood supply

Sawadogo

Baguiya

Yougbare

et al. 2019

Transfusion Medicine

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“…19 Vairo and others have estimated that although sensitivity of IgG enzyme immunoassay test for dengue is nearly 100%, specificity could be substantially diminished in African populations. 20 Taken all together, these data suggest that prevalence studies using anti-dengue IgG antibodies in the African continent may be overestimating dengue infection and should be interpreted cautiously.…”

Section: Discussionmentioning

confidence: 98%

Imported Dengue Infection in a Spanish Hospital with a High Proportion of Travelers from Africa: A 9-Year Retrospective Study

Toro¹,

Trevisi²,

López-Quintana³

et al. 2017

The American Society of Tropical Medicine and Hygiene

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Abstract. Epidemiological data on dengue in Africa are still scarce. We investigated imported dengue infection among travelers with a high proportion of subjects from Africa over a 9-year period. From January 2005 to December 2013, blood samples from travelers with clinical suspicion of dengue were analyzed. Dengue was diagnosed using serological, antigen detection, and molecular methods. Subjects were classified according to birthplace (Europeans versus non-Europeans) and last country visited. Overall, 10,307 serum samples corresponding to 8,295 patients were studied; 62% were European travelers, most of them from Spain, and 35.9% were non-Europeans, the majority of whom were born in Africa (mainly Equatorial Guinea) and Latin America (mainly Bolivia, Ecuador, and Colombia). A total of 492 cases of dengue were identified, the highest number of cases corresponding to subjects who had traveled from Africa (N = 189), followed by Latin America (N = 174) and Asia (N = 113). The rate of cases for Africa (4.5%) was inferior to Asia (9%) and Latin America (6.1%). Three peaks of dengue were found

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Dengue RNA detection and seroprevalence in blood donors during an outbreak in the São Paulo State, Brazil, 2016

Slavov

Santos

Hespanhol

et al. 2020

Journal of Medical Virology

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Most dengue virus (DENV) infections remain asymptomatic. This increases the risk of DENV transfusion transmission (TT‐DENV) during outbreaks. We evaluated DENV viremia in 8475 blood donations assembled in minipools for the presence of DENV RNA. The tested samples were obtained between February and May, 2016, during a large DENV outbreak in Ribeirão Preto city, northeast region of the São Paulo State, Brazil. The DENV RNA + samples were serotyped and screened for DENV NS1. We also tested a significant number of plasma samples (n = 372) to estimate the DENV seroprevalence among blood donors in the region. We detected three DENV RNA + samples in the tested blood donations (n = 3/8475, 0.04%). From these, two samples were further serotyped as DENV‐1 and one sample as DENV‐2. All DENV RNA positive samples were negative for anti‐DENV IgG, indicating the presence of primary acute infection. Moreover, two of the DENV RNA + samples were also NS1 antigen positive (antigenemia). The anti‐DENV IgG seroprevalence among blood donor population was 50.8% (n = 189/372). Our results are in accordance with the presence of DENV primary infection in blood donors which can lead to transfusion transmission of the infection to recipients. Measures to exclude such donors should be adopted to prevent TT‐DENV.

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IgG Against Dengue Virus in Healthy Blood Donors, Zanzibar, Tanzania

Cited by 35 publications

References 9 publications

Seroprevalence and factors associated with IgG anti‐DENV positivity in blood donors in Burkina Faso during the 2016 dengue outbreak and implications for blood supply

Seroprevalence and factors associated with IgG anti‐DENV positivity in blood donors in Burkina Faso during the 2016 dengue outbreak and implications for blood supply

Imported Dengue Infection in a Spanish Hospital with a High Proportion of Travelers from Africa: A 9-Year Retrospective Study

Dengue RNA detection and seroprevalence in blood donors during an outbreak in the São Paulo State, Brazil, 2016

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