<b>The Randomized Physiologic Assessment of Thrombus Aspiration in Patients with Acute ST‐Segment Elevation Myocardial Infarction Trial (PATA STEMI):</b> Study Rationale and Design

Orlić, Dejan; Ostojić, Miodrag; Beleslin, Branko; Tešić, Milorad; Labudović‐Borović, Milica; Vukčević, Vladan; Stojković, Siniša; Nedeljković, Milan; Stanković, Goran

doi:10.1111/joic.12105

Cited by 5 publications

(1 citation statement)

References 49 publications

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“…Myocardial infarction (MI) is the death of cardiomyocytes caused by obstruction of one or more arteries supplying the heart ( 1 , 2 ). Clinically, patients with MI often show a number of different symptoms including pain, fever and increased white blood cell count ( 3 ). The pivotal pathological characteristic after MI is cardiac fibrosis, which leads to cardiac remodeling and failure ( 4 , 5 ).…”

Section: Introductionmentioning

confidence: 99%

Uncovering potential differentially expressed miRNAs and targeted mRNAs in myocardial infarction based on integrating analysis

Wang¹,

Cao²

2020

Mol Med Rep

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Myocardial infarction (Mi) is one of the leading causes of death globally. The aim of the present study was to find valuable micrornas (mirnas/mirs) and target mrnas in order to contribute to our understanding of the pathology of Mi. mirna and mrna data were downloaded for differential expression analysis. Then, a regulatory network between mirnas and mrnas was established, followed by function annotation of target mrnas. Thirdly, prognosis and diagnostic analysis of differentially methylated target mrnas were performed. Finally, an in vitro experiment was used to validate the expression of selected mirnas and target mrnas. a total of 19 differentially expressed mirnas and 1,007 differentially expressed mRNAs were identified. Several regulatory interaction pairs between mirna and mrnas were identified, such as hsa-mir-142-2p-long-chain-fattyacid-coa ligase 1 (acSl1), hsa-mir-15a-3p-nicotinamide phosphoribosyltransferase (naMPT), hsa-mir-33b-5p-regulator of G-protein signaling 2 (rGS2), hsa-mir-17-3p-Jun dimerization protein 2 (JdP2), hsa-mir-24-1-5p-aquaporin-9 (aQP9) and hsa-mir-34a-5p-STaT1/aKT3. of note, it was demonstrated that acSl1, naMPT, rGS2, JdP2, aQP9, STaT1 and aKT3 had diagnostic and prognostic values for patients with Mi. in addition, STaT1 was involved in the 'chemokine signaling pathway' and 'Jak-STaT signaling pathway'. aKT3 was involved in both the 'MaPK signaling pathway' and 'T cell receptor signaling pathway'. reverse transcription-quantitative Pcr validation of hsa-mir-142-3p, hsa-mir-15a-3p, hsa-mir-33b-5p, acSl1, naMPT, rGS2 and JdP2 expression was consistent with the bioinformatics analysis. In conclusion, the identified miRNAs and mRNAs may be involved in the pathology of Mi.

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Section: Introductionmentioning

confidence: 99%

Uncovering potential differentially expressed miRNAs and targeted mRNAs in myocardial infarction based on integrating analysis

Wang¹,

Cao²

2020

Mol Med Rep

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The Potential Use of the Index of Microcirculatory Resistance to Guide Stratification of Patients for Adjunctive Therapy in Acute Myocardial Infarction

Maznyczka

Oldroyd

McCartney

et al. 2019

JACC: Cardiovascular Interventions

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Effects of atorvastatin on serum lipids, cardiomyocyte apoptosis and related genes in rats

Zhu

Song

et al. 2020

Journal of King Saud University - Science

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The Randomized Physiologic Assessment of Thrombus Aspiration in Patients with Acute ST‐Segment Elevation Myocardial Infarction Trial (PATA STEMI): Study Rationale and Design

Abstract: If manual thrombus aspiration significantly reduces microcirculatory resistance, thereby improving myocardial perfusion, it may become the routine strategy in primary PCI.

Cited by 5 publications

References 49 publications

Uncovering potential differentially expressed miRNAs and targeted mRNAs in myocardial infarction based on integrating analysis

Uncovering potential differentially expressed miRNAs and targeted mRNAs in myocardial infarction based on integrating analysis

The Potential Use of the Index of Microcirculatory Resistance to Guide Stratification of Patients for Adjunctive Therapy in Acute Myocardial Infarction

Effects of atorvastatin on serum lipids, cardiomyocyte apoptosis and related genes in rats

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