Covalent TiO2/pectin microspheres with Fe3O4 nanoparticles for magnetic field-modulated drug delivery

Abstract

Covalent TiO(2)-co-pectin microspheres containing Fe(3)O(4) nanoparticles were developed through an ultrasound-induced crosslinking/polymerization reaction between the glycidyl methacrylate from vinyl groups in TiO(2) and in pectin. ζ-potentials became less negative in the nanostructured microspheres, caused by the presence of both inorganic particles in the negatively charged pectin. The nanostructured pectin microspheres showed an amoxicillin release rate slower than that of pure pectin microspheres. The proposed microspheres were found to be a sustained release system of amoxicillin in the acid medium. Furthermore, the antibiotic release may be modulated by exposition of the microspheres to a remote magnetic field. In practical terms, the nanostructured microspheres could deliver a larger proportion of their initial load to specific site of action. The cytotoxic concentrations for 50% of VERO cells (CC(50)), calculated as the concentration required to reduce cell viability by 50% after 72h of incubation, for pectin-only microspheres and nanostructured pectin microspheres were 217.7±6.5 and 121.5±4.9μgmL(-1), respectively. The obtained CC(50) values indicated acceptable cytotoxic levels for an incubation period of 72h, showing that the pectin microspheres have a great pharmacological potential for uses in biological environments, even after the introduction of both Fe(3)O(4) and TiO(2).

Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems

“…Their approach was validated as the surrounding normal tissues were completely left intact after a two-minute exposure to AMF (38 kA m −1 ) at 980 kHz during which the target tumor tissue was heated to 60 °C. In a study by Silva et al , 143 antibiotics were loaded into a nanostructure composed of Fe 3 O 4 NPs with a TiO 2 - co -pectin shell then were released slowly by application of a remote magnetic field.…”

In Situ Synthesis of Magnetic Field-Responsive Hemicellulose Hydrogels for Drug Delivery

“… 24 Covalent TiO 2 - co -pectin microspheres containing Fe 3 O 4 nanoparticles were developed using an ultrasound-induced cross-linking/polymerization reaction, resulting in a material with the potential for use in biological environments. 25 However, multistep reactions of these organic/inorganic composite hydrogels as well as their tedious purification may limit their use. Therefore, a facile approach for the preparation of magnetic field-responsive polysaccharide hydrogels is desired.…”

Cobalt Oxide Nanoparticles: Behavior towards Intact and Impaired Human Skin and Keratinocytes Toxicity

“…Magnetic nanoparticles have been proposed in many biomedical applications, such as cancer diagnosis [ 1 ], radioactive vectors in cancer therapy [ 2 ], and as drug delivery systems [ 3 ]. CoO and Co 3 O 4 are two important forms among the various cobalt oxides based on their distinctive structural features and properties [ 4 ] and it has been demonstrated that these transition metal oxides, when falling in the nanosized regime, have even more attractive applications such as, e.g.…”