'Benifuuki' Green Tea Containing O-Methylated Catechin Reduces Symptoms of Japanese Cedar Pollinosis: A Randomized, Double- Blind, Placebo-Controlled Trial

Masuda, Sawako; Maeda‐Yamamoto, Mari; Usui, Satoko; Fujisawa, Takao

doi:10.2332/allergolint.13-oa-0620

Cited by 44 publications

(34 citation statements)

References 25 publications

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“…Numerous studies have shown that catechinshave anti-cancer, hypotensive, and hypocholesterolemic activities [5][6][7][8][9][10]. Consistently, inverse relationships between green tea consumption and the reduction of cancer incidence, the risk of developing hypertension, and cholesterol level have also been demonstrated in epidemiological studies.…”

Section: Introductionmentioning

confidence: 55%

Green Tea Catechins -Pharmacokinetic Properties and Health Beneficial Effects

ErisaTomishige¹

2015

Pharm Anal Acta

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In this review, we provide information on thepharmacokinetic properties of green tea catechins and their beneficial health effects. The major catechins in green tea are (-)-epicatechin (EC), its hydroxyl derivative (-)-epigallocatechin (EGC), and their gallic acid esters, (-)-epicatechin-3-gallate (ECg) and (-)-epigallocatechin-3-gallate (EGCg). We developed an analytical method for determination of the presence of green tea catechins in human serum using ion-pair HPLC with electrochemical detection to estimate the pharmacokinetic parameters of target catechins. The C max values indicated that catechin absorption was relatively low. One of the gallatedcatechins, EGCg, had a longer half-life than the non-gallatedcatechins. Green tea catechins, in particular, have attracted attention as cancer preventive agents in terms of their low toxicity and being readily available to the general population. Several epidemiological studies revealed that green tea consumption reduces cancer incidence. Numerous in vitro cell culture studies have shown that EGCg, which is defined as a major green tea catechin contributing to green tea's anticancer effects, inhibits cell growth concomitant with induction of apoptosis. We have previously found that the cell death-inhibiting gene, Bcl-xL, was decreased by EGCg. These results support the hypothesis that EGCg regulates cytoplasmic NF-κB and subsequently induction of apoptosis. Green tea consumption may also play a role in preventing other lifestyle diseases, such as cardiovascular diseases and stroke, due to its hypocholesterolemic and hypotensive activities. In conclusion, habitual green tea drinking may promote human health by preventing lifestyle-related diseases.

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Section: Introductionmentioning

confidence: 55%

Green Tea Catechins -Pharmacokinetic Properties and Health Beneficial Effects

ErisaTomishige¹

2015

Pharm Anal Acta

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“…[7][8][9] Fujisawa et al evaluated the efficacy of 'Benifuuki' green tea in alleviating Japanese cedar pollinosis which contained 5.83 mg mL −1 epigallocatechin-3-O-(3-O-methyl) gallate (EGCG3 ′′ Me). 10 After drinking 700 mL of 'Benifuuki' green tea per day for 4 months, a significant reduction of cedar pollen allergic symptoms was observed for the patients compared with the 'Yabukita' intake group, which did not contain EGCG ′′ Me. The reason for EGCG3 ′′ Me's antiallergic effect was attributed to suppression of the release of histamine and leukotrienes from mast cells by EGCG3 ′′ Me.…”

Section: Introductionmentioning

confidence: 92%

“…In particular, methylated catechins were intensively studied as functional ingredients for reduction of allergy . Fujisawa et al evaluated the efficacy of ‘Benifuuki’ green tea in alleviating Japanese cedar pollinosis which contained 5.83 mg mL −1 epigallocatechin‐3‐ O ‐(3‐ O ‐methyl) gallate (EGCG3″Me) . After drinking 700 mL of ‘Benifuuki’ green tea per day for 4 months, a significant reduction of cedar pollen allergic symptoms was observed for the patients compared with the ‘Yabukita’ intake group, which did not contain EGCG″Me.…”

Section: Introductionmentioning

confidence: 99%

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Regiospecific methylation of all the hydroxyls in (+)‐catechin by a stepwise differentiation strategy

et al. 2019

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BACKGROUND Methylated derivatives of catechins have received great attention for health beneficial effects, especially antiallergic activity. However, the scarce natural abundance of methylated catechins limits further bioactive studies. The objective of this work was to investigate regiospecific methylation of the hydroxyls of (+)‐catechin through a stepwise differentiation strategy based on electronic difference between the hydroxyl groups. RESULTS Selective methylation of the hydroxyls on different rings was realized by employing Meerwein salt as the methylation reagent. Preferential acylation of the phenolic hydroxyls on A and B rings allowed selective exposure of the aliphatic hydroxyl on C ring to methylation. The vicinal phenolic hydroxyls on B ring were preferentially methylated under mild basic condition due to the acidic properties. Methylation of the phenolic hydroxyls on A ring was achieved by sequential protection and deprotection operations. Finally, antioxidant activities of all the individual methylated (+)‐catechins were explored by 2,2′‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulfonic acid) assay. CONCLUSION Regiospecific methylation of the phenolic and aliphatic hydroxyls was systematically achieved under mild conditions. Preparation of all the individual methylated (+)‐catechins was accomplished with a greener methylation reagent: nonvolatile Meerwein salt. This work laid a solid foundation for preparation of diverse O‐methylated catechins for bioactivity studies. © 2019 Society of Chemical Industry

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“…Compared to EGCG, EGCG3′′Me is reported to have a significantly higher bioavailability [46]. Benifuuki tea also proved to be more effective in treating allergies [47] than the common Yabukita tea, a cultivar that does not contain any methylated EGCG. …”

Section: Introductionmentioning

confidence: 99%

A Randomized Controlled Trial of Green Tea Beverages on the in vivo Radical Scavenging Activity in Human Skin

Megow¹,

Darvin²,

Meinke³

et al. 2017

Skin Pharmacol Physiol

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Background: Oxidative stress plays an important role in the pathogenesis of various skin diseases. Thus, the antioxidant network of the skin relies on the uptake of exogenous antioxidants to ensure cell protection against radical formation. Green tea is one of the main sources of polyphenolic antioxidant compounds, but only few data are available on its cutaneous antioxidant effects. Methods: The radical scavenging properties of Benifuuki and Yabukita green tea were investigated in the human skin. Thirty-two participants who met the inclusion criteria were randomized to consume 3 cups per day of either Benifuuki tea, Yabukita tea, or water (control group) for 2 weeks. Electron paramagnetic resonance (EPR) spectroscopy was applied to measure the radical scavenging capacity of the skin in vivo before and after the intervention. Results: Both Yabukita and Benifuuki tea led to an increase in the radical scavenging activity of the skin by 28 and 29%, respectively, and the difference was significant when compared to the control group. Benifuuki tea, previously reported to be superior in bioavailability due to a highly absorbable methylated catechin, did not prove to be more effective than the common Yabukita tea. Conclusion: The results show that green tea enhances the radical scavenging capacity of the skin and support the hypothesis that green tea may offer protection against cutaneous oxidative stress.

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'Benifuuki' Green Tea Containing O-Methylated Catechin Reduces Symptoms of Japanese Cedar Pollinosis: A Randomized, Double- Blind, Placebo-Controlled Trial

Abstract: 'Benifuuki' green tea containing a large amount of O-methylated EGCG reduced the symptoms of JCP and has potential as a complementary/alternative medicine for treating seasonal allergic rhinitis.

Cited by 44 publications

References 25 publications

Green Tea Catechins -Pharmacokinetic Properties and Health Beneficial Effects

Green Tea Catechins -Pharmacokinetic Properties and Health Beneficial Effects

Regiospecific methylation of all the hydroxyls in (+)‐catechin by a stepwise differentiation strategy

A Randomized Controlled Trial of Green Tea Beverages on the in vivo Radical Scavenging Activity in Human Skin

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