Incidence of esophageal adenocarcinoma in Barrett's esophagus with low-grade dysplasia: a systematic review and meta-analysis

Endoscopic therapy for Barrett's oesophagus

“…A recent meta-analysis and systematic review estimated the incidence of progression (to HGD or EAC) in LGD to be 0.54 to 1.73 % per year [42]. This was limited by substantial heterogeneity in the studies and the varying natural history of LGD in different studies.…”

Esophageal adenocarcinoma in Barrett’s esophagus with low-grade dysplasia

“…Singh et al 1 have written a comprehensive review of Barrett's esophagus containing low-grade dysplasia, but they appear to have misinterpreted some of their own data. They state that they "were unable to identify a high-risk subset of patients with low-grade dysplasia who were likely to progress to cancer," but that is in fact not the case.…”

“…The meta-analysis by Singh et al, 1 which is a mix of mostly unconfirmed low-grade dysplasia studies and a minority of studies with confirmed cases, almost certainly includes large numbers of patients who did not actually have low-grade dysplasia. This is a major flaw of the study and renders the conclusions unreliable.…”

Epidemiology and Risk Factors for Esophageal Cancer

“…A more recent meta-analysis from 2014 analyzed the incidence of EAC and high-grade dysplasia in Barrett's esophagus patients with low-grade dysplasia [ 22 ]. The annual incidence of EAC was 0.54 % (95 % CI: 0.32-0.76).…”