Haff disease associated with the ingestion of the freshwater fish Mylossoma duriventre (pacu-manteiga)

Júnior, Oswaldo Tolesani; Roderjan, Christian Nejm; Neto, Edgard do Carmo; Ponte, Micheli Mikaeli; Seabra, Mariana Cristina Pelli; Knibel, Marcos Freitas

doi:10.5935/0103-507x.20130058

Cited by 19 publications

(16 citation statements)

References 6 publications

(16 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In modern times, this syndrome of unexplained myalgia and rhabdomyolysis occurring within 24 h of consumption of certain types of cooked seafood [1,2,3,4] has remained rare and had not been reported outside the Americas [2,6,7,8]. Isolated cases of milder presentations with less specific symptoms (e.g., weakness, abdominal pain, diarrhea, and vomiting) could be easily missed [21].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The Emergence and Epidemiology of Haff Disease in China

Chan

2016

Toxins

View full text Add to dashboard Cite

Haff disease is a rare syndrome of unexplained myalgia and rhabdomyolysis occurring within 24 h of consumption of certain types of cooked freshwater fish or crustacean. It is caused by a yet unidentified heat-stable toxin. In the present review of published case studies and official press releases, the main objective is to report the emergence and epidemiology of Haff disease in China. Haff disease first occurred in Beijing in 2000 and in Lianzhou and Liannan, Guangdong Province in 2009. Subsequent outbreaks mostly occurred in the Jiangsu Province—Nanjing, Yangzhou, Huai’an, and Yancheng. Isolated outbreaks occurred in other cities since 2010—Shijiazhuang, Yueyang, Shanghai, Wuhu, Baoding, Shenzhen, and Hong Kong (imported cases from Shenzhen). Outbreaks occurred predominately in the summer. Crayfish accounted for almost all the outbreaks. Two large outbreaks occurred in Lianzhou and Liannan in 2009 (n = 54) after eating pomfrets and in Nanjing in 2010 (n = 42) after eating crayfish. Other reports or outbreaks involved only 1–9 subjects (median 2 subjects). Variability in individual susceptibility and attack rates were noted, with many subjects remaining asymptomatic despite sharing the same seafood meal as the index cases. Adults were predominately involved. Symptoms occurred within 3–20 h of seafood ingestion, including myalgia, weakness, and, less frequently, nausea, vomiting, abdominal pain, and diarrhea. Myalgia and muscle weakness should normally subside within 2–3 days. Serum creatine phosphokinase became normal within 5–6 days. Abnormal renal function was uncommon. Serious complications (renal failure, multi-organ failure, and prolonged myopathy) and death were rare. In any subjects with unexplained myalgia and rhabdomyolysis, seafood consumption should be included in the history. All suspected cases of Haff disease, including milder presentations, should be reported to public health authorities.

show abstract

Section: Discussionmentioning

confidence: 99%

“…In Sweden and the former Soviet Union, outbreaks occurred from 1934 to 1984 [2,6]. In the Americas, Haff disease was known to occur in the U.S. (since 1984) [1] and the Brazilian Amazon (2008–2011) [7,8]. …”

Section: Introductionmentioning

confidence: 99%

The Emergence and Epidemiology of Haff Disease in China

Chan

2016

Toxins

View full text Add to dashboard Cite

show abstract

“…RM results from direct and indirect causes, such as crush injury, medications, infections, myopathies, muscular dystrophies, and various other diseases [2]. In Haff disease, the development of RM within 24 hours following ingestion of shellfish and certain freshwater fishes, has also been reported worldwide [3]. However, the exact pathogenesis of RM remains unclear, and RM treatment and care are limited.…”

Section: Introductionmentioning

confidence: 99%

Curcumin-Loaded Nanoparticles Protect Against Rhabdomyolysis-Induced Acute Kidney Injury

Chen

Sun

et al. 2017

Cell Physiol Biochem

View full text Add to dashboard Cite

Background/Aims: Rhabdomyolysis (RM) is a potentially life-threatening condition that results from the breakdown of muscle and consequent release of toxic compounds into circulation. The most common and severe complication of RM is acute kidney injury (AKI). This study aimed to evaluate the efficacy and mechanisms of action of curcumin-loaded nanoparticles (Cur-NP) for treatment of RM-induced AKI. Methods: Curcumin-NP was synthesized using the nanocarrier distearoylphosphatidylethanolamine-polyethylene glycol (DSPE-PEG) to achieve a prolonged and constant drug release profile compared with the curcumin-free group. The anti-AKI effects of Curcumin-NP were examined both in vitro (myoglobin-treated renal tubular epithelial HK-2 cells) and in vivo (glycerol-induced AKI model). Results: Our results indicated that Curcumin-NP reversed oxidative stress, growth inhibition and cell apoptosis accompanied with down-regulation of apoptotic markers Caspase-3 and GRP-78 in vitro. In vivo studies revealed enhanced AKI treatment efficacy with Curcumin-NP as characterized by reduced serum creatine phosphokinase (CPK), creatinine (Cr) and urea and less severe histological damage in renal tubules. In addition, kidney tissues from Curcumin-NP-treated AKI rats exhibited reduced oxidative stress, apoptosis, and cleaved Capase-3 and GRP-78 expression. Conclusion: Our results suggest that nanoparticle-loaded curcumin enhances treatment efficacy for RM-induced AKI both in vitro and in vivo.

show abstract

“…Generally, neurological abnormalities, fever, splenomegaly, or hepatomegaly are not observed. ( 1 - 5 ) All patients suffering from Haff disease report a history of eating fish (pomfret, buffalo, or crayfish) within 24 hours before the onset of illness. ( 6 , 7 ) A few patients have died from Haff disease, but most survive and recover quickly.…”

Section: Discussionmentioning

confidence: 99%

“…( 1 ) Since the first report, outbreaks of Haff disease have been reported in Sweden, the former Soviet Union, the United States, Brazil, and China. ( 2 - 5 ) Haff disease is a rare clinical syndrome. If patients receive prompt treatment, the prognosis is good.…”

Section: Introductionmentioning

confidence: 99%

Haff disease complicated by multiple organ failure after crayfish consumption: a case study

Feng¹,

Luo²,

Zhuang³

et al. 2014

Revista Brasileira De Terapia Intensiva

View full text Add to dashboard Cite

Haff disease is a syndrome consisting of unexplained rhabdomyolysis. Patients suffering from Haff disease report having eaten fish within 24 hours before the onset of illness. Most patients survive and recover quickly. The present study is the first report of Haff disease complicated by multiple organ failure after crayfish consumption. A 66-year-old Chinese man ate cooked crayfish on the night of June 23, 2013. He arrived at our hospital 2 days later and was admitted to the intensive care unit. After admission, the patient was diagnosed with Haff disease complicated by multiple organ failure. Despite supportive and symptomatic treatments, the condition of the patient deteriorated, and he died due to his illness.Haff disease is a rare clinical syndrome that is sometimes misdiagnosed. Early diagnosis and proper treatment are essential to prevent progression to multiple organ failure.

show abstract

Haff disease associated with the ingestion of the freshwater fish Mylossoma duriventre (pacu-manteiga)

Cited by 19 publications

References 6 publications

The Emergence and Epidemiology of Haff Disease in China

The Emergence and Epidemiology of Haff Disease in China

Curcumin-Loaded Nanoparticles Protect Against Rhabdomyolysis-Induced Acute Kidney Injury

Haff disease complicated by multiple organ failure after crayfish consumption: a case study

Contact Info

Product

Resources

About