“…Pain can limit this treatment; thus several strategies have been evaluated to increase the compliance. Among these, ice with pressure, ice <20 or >20 seconds associated or not with topical anesthesia [ 23 , 24 ], general anesthesia, nerve blocks, vibration, pressure [ 21 ], and needle-free injections (Med-Jet MBX, Medical International Technologies, Montreal, QC, Canada) [ 25 ]. However, an open-label prospective study involving 20 patients with palmar HH, treated with needle injection on the right hand and with a needle-free device, has proven the efficacy of the device to be lower as compared to the classic needle injection [ 25 ].…”