“…Dawes et al (2014) investigated cross-strain genomic variation and gene expression differences between low-active C3H/HeJ and high-active C57L/J inbred mice in nine of the genes with reported direct or indirect association to physical activity: actinin 2 (Actn2), actinin 3 (Actn3), calsequestrin 1 (Casq1), dopamine receptor 2 (Drd2), leptin receptor (Lepr), melacortin 4 receptor (Mcr4), myostatin (Mstn), 3 -phosphoadenosine 5 -phosphosulfate 2 (Papss2) and glucose transporter 4 (Glut4). First, between-strain structural genomic differences were identified in the haplotypes of Actn2, Casq1, Drd2, Lepr, and Papss2, but all SNPs differing between low-active and high active mice were non-coding, not in promoter regions, and not linked to known miRNA targets.…”