Glycosylflavonoids from Cecropia pachystachya Trécul are quorum sensing inhibitors

Brango-Vanegas, José; Costa, Geison Modesti; Ortmann, Caroline Flach; Schenkel, Eloir Paulo; Reginatto, Flávio Henrique; Ramos, Freddy A.; Arevalo-Ferro, Catalina; Castellanos, Leonardo

doi:10.1016/j.phymed.2014.01.001

Cited by 53 publications

(35 citation statements)

References 16 publications

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“…Studies have showed that caffeic acid, chlorogenic acid, rutin, p-coumaric acid, luteolin and quercetin exhibited high antibacterial activity (Widmer and Laurent 2006;Lou et al 2010Lou et al , 2012Fratianni et al 2013;Srinivas and Reddy 2014;Dezsi et al 2015;Dunkic et al 2015). Other studies indicated that chlorogenic acid and rutin were identified as QS inhibitors, and none of these compounds inhibited the growth of the used biosensors (Truchado et al 2012;Brango-Vanegas et al 2014). Our results showed that the combination of chlorogenic acid, caffeic acid, p-coumaric acid, rutin and quercetin significantly improved the inhibition activity of burdock leaf fraction on biofilm formation.…”

Section: Discussionmentioning

confidence: 48%

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The effect of burdock leaf fraction on adhesion, biofilm formation, quorum sensing and virulence factors ofPseudomonas aeruginosa

et al. 2017

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Section: Discussionmentioning

confidence: 48%

“…; Brango‐Vanegas et al . ). Our results showed that the combination of chlorogenic acid, caffeic acid, p ‐coumaric acid, rutin and quercetin significantly improved the inhibition activity of burdock leaf fraction on biofilm formation.…”

Section: Discussionmentioning

confidence: 97%

The effect of burdock leaf fraction on adhesion, biofilm formation, quorum sensing and virulence factors ofPseudomonas aeruginosa

et al. 2017

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“…Production of QS inhibitors can have a role in securing a foothold in a surface environment by inhibiting the attachment of marine bacteria, and consequently of larvae, algae and barnacles (Goecke et al, 2010;Wahl et al, 2010). Described QS inhibitors include furanones and their analogs (Zang et al, 2009), bismuth porphyrin complexes (Galkin et al, 2015) or glycosylated flavonoids (Brango-Vanegas et al, 2014). A study demonstrated that kojic acid inhibited QS activity and formation of microbial communities on glass slides, decreasing both the densities of bacteria and diatoms (Dobretsov et al, 2011).…”

Section: Induction Of Larval Settlementmentioning

confidence: 99%

Marine biofilms: diversity of communities and of chemical cues

Antunes

Leão

Vasconcelos

2018

Environ Microbiol Rep

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Summary Surfaces immersed in seawater are rapidly colonized by various microorganisms, resulting in the formation of heterogenic marine biofilms. These communities are known to influence the settlement of algae spores and invertebrate larvae, triggering a succession of fouling events, with significant environmental and economic impacts. This review covers recent research regarding the differences in composition of biofilms isolated from different artificial surface types and the influence of environmental factors on their formation. One particular phenomenon – bacterial quorum sensing (QS) – allows bacteria to coordinate swarming, biofilm formation among other phenomena. Some other marine biofilm chemical cues are believed to modulate the settlement and the succession of macrofouling organisms, and they are also reviewed here. Finally, since the formation of a marine biofilm is considered to be an initial, QS‐dependent step in the development of marine fouling events, QS inhibition is discussed on its potential as a tool for antibiofouling control in marine settings.

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“…Así, la actividad IQS fue detectada cuando hubo inhibición en la producción de violaceína sin que hubiera inhibición del crecimiento bacteriano. Como controles positivos se emplearon: a) ácido kojico (90 µg/disco) b) un extracto de Cecropia pachystachya (10 µg/disco) (19). Como controles negativos se emplearon los sensidiscos impregnados con los disolventes en que se aplicaron las muestras, es decir MeOH y DCM, y su posterior evaporación.…”

Section: Ensayo De Inhibición De Quorum Sensing (Iqs)unclassified

Búsqueda de bacterias marinas como fuente de inhibidores de quorum sensing (iqs): primer estudio químico de Oceanobacillus profundus (RKHC-62B)

Martínez-Matamoros¹,

FONSECA²,

Duque³

et al. 2016

Vitae

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RESUMENAntecedentes: Los productos naturales aislados de microorganismos marinos han demostrado tener un amplio rango de actividades biológicas incluyendo inhibidores de quorum sensing. Objetivos: Estudiamos quince cepas bacterianas del phylum Firmicutes aisladas del coral blando Antillogorgia elisabethae que fueron evaluadas como una nueva fuente sostenible de compuestos inhibidores de quorum sensing (IQS). Métodos: Se prepararon cultivos en cuatro medios diferentes y extraídos usando una resina no iónica. Todos los extractos fueron probados con el fin de establecer su actividad inhibitoria de quorum sensing (IQS) usando Chromobacterium violaceum ATCC 31532 como biosensor. Los extractos activos fueron fraccionados mediante cartuchos RP-18. Cada fracción fue evaluada mediante bioensayo y analizada por HPLC. Resultados: Las fracciones metanólicas de Jeotgalicoccus halophilus y Oceanobacillus profundus fueron las más activas, lo cual sugiere que los compuestos no polares pueden ser los responsables de esta actividad. Conclusiones: El estudio químico del extracto orgánico de O. profundus cultivado en medio LBS permitió aislar los compuestos tirosol (1) y acetato de tirosol (2) como los responsables de la actividad IQS. Palabras clave: Productos naturales marinos, Microorganismos marinos, Jeotgalicoccus halophilus, Oceanobacillus profundus, Compuestos inhibidores de quorum sensing. ABSTRACTBackground: Natural products isolated from marine microorganisms have demonstrated a wide range of biological activities included quorum sensing inhibitors. Objectives: We study fifteen marine Firmicutes bacterial strains isolated from the Caribbean soft coral Antillogorgia elisabethae that were evaluated as a novel and sustainable source of quorum sensing inhibitor compounds. Methods: Cultures were made in four different culture media and further extracted using a non-ionic resin. All these extracts were tested in order to establish its quorum sensing inhibition (QSI) activity using Chromobacterium violaceum ATCC 31532. The active extracts were fractionated by RP-18 cartridge. Each fraction was tested and evaluated for its composition by HPLC-PDA. Results: Methanol fractions of Jeotgalicoccus halophilus and Oceanobacillus profundus were the most active ones, suggesting that non-polar compounds could be the responsible for the QSI activity of the bacterial extracts here tested. Conclusions: The chemical study

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Glycosylflavonoids from Cecropia pachystachya Trécul are quorum sensing inhibitors

Cited by 53 publications

References 16 publications

The effect of burdock leaf fraction on adhesion, biofilm formation, quorum sensing and virulence factors ofPseudomonas aeruginosa

The effect of burdock leaf fraction on adhesion, biofilm formation, quorum sensing and virulence factors ofPseudomonas aeruginosa

Marine biofilms: diversity of communities and of chemical cues

Búsqueda de bacterias marinas como fuente de inhibidores de quorum sensing (iqs): primer estudio químico de Oceanobacillus profundus (RKHC-62B)

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