Photophysicochemical behavior and antimicrobial activity of dihydroxosilicon tris(diaquaplatinum)octacarboxyphthalocyanine

Managa, Muthumuni; Idowu, Mopelola Abidemi; Antunes, Edith; Nyokong, Tebello

doi:10.1016/j.saa.2014.01.087

Cited by 16 publications

(12 citation statements)

References 35 publications

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“…We have recently reported on the improved photoinactivation activity (against Candida albicans and Escherichia coli) using a neutral planinated silicon phthalocyanine [15]. The current work reports on the potentially more effective cationic complex 1 (Fig.…”

Section: Introductionmentioning

confidence: 92%

Photoinactivation of Candida albicans and Escherichia coli using aluminium phthalocyanine on gold nanoparticles

Mthethwa

Nyokong

2015

Photochem Photobiol Sci

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The conjugates of aluminium phthalocyanine (complex 1) with gold nanorods (complex 1–AuNRs) and bipyramids (complex 1–AuBPs) showed improved singlet oxygen quantum yields of 0.23 and 0.24, respectively, compared to that of complex 1 alone at 0.12. Complex 1 and its conjugates were used for the photoinactivation of fungi (C. albicans) and bacteria cells (E. coli). The Q band absorbances were the same for the Pc alone and when conjugated to AuNPs. The efficiency of these conjugates was evaluated by measuring the log reduction of the microorganisms (C. albicans and E. coli) after irradiation with visible light in the presence of photosensitizers. Aluminium phthalocyanine alone showed log1.78 and log2.51 reductions for C. albicans and E. coli respectively. However, the conjugates showed higher photosensitization with log2.08 and log3.34 for C. albicans and E. coli, respectively using 1–AuBPs. For complex 1–AuNRs log2.53 and log3.71 were achieved for C. albicans and E. coli respectively. The statistical analysis of the results showed that the enhanced photoinactivation observed in both microorganisms was irrespective of the shape of the nanoparticles conjugated. Photoinactivation of C. albicans was less than that of E. coli even though a higher concentration of complex 1 or its conjugates was used in C. albicans.

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Section: Introductionmentioning

confidence: 92%

Photoinactivation of Candida albicans and Escherichia coli using aluminium phthalocyanine on gold nanoparticles

Mthethwa

Nyokong

2015

Photochem Photobiol Sci

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“…[3][4][5] In particular, Pc derivatives have been exploited as photosensitizers (PS) for photodynamic therapy (PDT), evidencing a high potential in cancer treatment, [6][7][8][9][10][11][12] in the photodynamic inactivation (PDI) of (multi)resistant microorganisms in infectious diseases [13][14][15][16][17][18] and/or in contaminated environmental matrices. 19 All these applications are based on cell death induced by reactive oxygen species (ROS), mainly singlet oxygen ( 1 O 2 ), generated by the combined action of visible light, molecular oxygen and a PS.…”

Section: Introductionmentioning

confidence: 99%

Inverted methoxypyridinium phthalocyanines for PDI of pathogenic bacteria

Lourenço

Sousa

Gomes

et al. 2015

Photochem Photobiol Sci

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Phthalocyanines (Pc) are photoactive molecules that can absorb and emit light in a large range of the UV-Vis spectrum with recognized potential for medical applications. Considering the biomedical applications an important limitation of these compounds is their low solubility in water. The use of suitable pyridinium groups on Pc is a good strategy to solve this drawback and to make them more effective to photoinactivate Gram-negative bacteria via a photodynamic inactivation (PDI) approach. Herein, an easy synthetic access to obtain inverted tetra- and octa-methoxypyridinium phthalocyanines (compounds 5 and 6) and also their efficiency to photoinactivate a recombinant bioluminescent strain of Escherichia coli is described. The obtained results were compared with the ones obtained when more conventional thiopyridinium phthalocyanines (compounds 7 and 8) were used. This innovative study comparing thiopyridinium and inverted methoxypyridinium moieties on cationic Pc is reported for the first time taking into account the efficiency of singlet oxygen ((1)O2) generation, water solubility and uptake properties.

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“…To combine the photodynamic activity of Pc and the cytotoxic effect of Pd and Pt complexes, SiPc derivatives bearing an axial palladium(II)–Schiff base complex ( 8 ) [26] and a peripheral tris(diaquaplatinum)octacarboxy groups ( 9 ) [27] were synthesized, and their photophysical and antimicrobial properties were studied. When compared with the unsubstituted SiPcCl 2 , the singlet oxygen quantum yield of 8 measured in DMSO increased from 0.18 to 0.47.…”

Section: Molecular Photosensitizersmentioning

confidence: 99%

Turning Photons into Drugs: Phthalocyanine‐Based Photosensitizers as Efficient Photoantimicrobials

Galstyan

2020

Chemistry A European J

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One of the most promising alternatives for treating bacterial infections is antimicrobial photodynamic therapy (aPDT), making the synthesis and application of new photoactive compounds called photosensitizers (PS) a dynamic research field. In this regard, phthalocyanine (Pc) derivatives offer great opportunities due to their extraordinary light‐harvesting and tunable electronic properties, structural versatility, and stability. This Review, rather than focusing on synthetic strategies, intends to overview current progress in the structural design strategies for Pcs that could achieve effective photoinactivation of microorganisms. In addition, the Review provides a concise look into the recent developments and applications of nanocarrier‐based Pc delivery systems.

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Photophysicochemical behavior and antimicrobial activity of dihydroxosilicon tris(diaquaplatinum)octacarboxyphthalocyanine

Cited by 16 publications

References 35 publications

Photoinactivation of Candida albicans and Escherichia coli using aluminium phthalocyanine on gold nanoparticles

Photoinactivation of Candida albicans and Escherichia coli using aluminium phthalocyanine on gold nanoparticles

Inverted methoxypyridinium phthalocyanines for PDI of pathogenic bacteria

Turning Photons into Drugs: Phthalocyanine‐Based Photosensitizers as Efficient Photoantimicrobials

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